- Strandwise translocation of a DNA glycosylase on undamaged DNA
[作者:Qi, Y; Nam, K; Spong, MC; Banerjee, A; Sung, RJ; Zhang, M; Karplus, M; Verdine, GL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1086-1091 , 文章类型: Article,,卷期:2012年109-4]
- Base excision repair of genotoxic nucleobase lesions in the genome is critically dependent upon the ability of DNA glycosylases to locate rare sites of damage embedded in a vast excess of undamaged DNA, using only therma...
- Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
[作者:Cassago, A; Ferreira, APS; Ferreira, IM; Fornezari, C; Gomes, ERM; Greene, KS; Pereira, HM; Garratt, RC; Dias, SMG; Ambrosio, ALB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1092-1097 , 文章类型: Article,,卷期:2012年109-4]
- Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of citric acid cycle anaplerosis. In this manuscript we present results that collectively demonstrate that, of the three major m...
- Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy
[作者:Bebeacua, C; Forster, A; McKeown, C; Meyer, HH; Zhang, XD; Freemont, PS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1098-1103 , 文章类型: Article,,卷期:2012年109-4]
- p97 is a key regulator of numerous cellular pathways and associates with ubiquitin-binding adaptors to remodel ubiquitin-modified substrate proteins. How adaptor binding to p97 is coordinated and how adaptors contribute ...
- Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish
[作者:Mishima, Y; Fukao, A; Kishimoto, T; Sakamoto, H; Fujiwara, T; Inoue, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1104-1109 , 文章类型: Article,,卷期:2012年109-4]
- MicroRNA (miRNA) is a class of small noncoding RNA approximately 22 nt in length. Animal miRNA silences complementary mRNAs via translational inhibition, deadenylation, and mRNA degradation. However, the underlying molec...
- Liquid crystal self-assembly of random-sequence DNA oligomers
[作者:Bellini, T; Zanchetta, G; Fraccia, TP; Cerbino, R; Tsai, E; Smith, GP; Moran, MJ; Walba, DM; Clark, NA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1110-1115 , 文章类型: Article,,卷期:2012年109-4]
- In biological systems and nanoscale assemblies, the self-association of DNA is typically studied and applied in the context of the evolved or directed design of base sequences that give complementary pairing, duplex form...
- Osmotic spreading of Bacillus subtilis biofilms driven by an extracellular matrix
[作者:Seminara, A; Angelini, TE; Wilking, JN; Vlamakis, H; Ebrahim, S; Kolter, R; Weitz, DA; Brenner, MP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1116-1121 , 文章类型: Article,,卷期:2012年109-4]
- Bacterial biofilms are organized communities of cells living in association with surfaces. The hallmark of biofilm formation is the secretion of a polymeric matrix rich in sugars and proteins in the extracellular space. ...
- Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice
[作者:Butler, R; Inzunza, J; Suzuki, H; Fujii-Kuriyama, Y; Warner, M; Gustafsson, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1122-1126 , 文章类型: Article,,卷期:2012年109-4]
- The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. Th...
- CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer
[作者:Zeng, QQ; Li, WD; Lu, D; Wu, ZZ; Duan, HX; Luo, YT; Feng, J; Yang, DL; Fu, L; Yan, XY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1127-1132 , 文章类型: Article,,卷期:2012年109-4]
- The epithelial-mesenchymal transition (EMT) plays an important role in breast cancer metastasis, especially in the most aggressive and lethal subtype, "triple-negative breast cancer" (TNBC). Here, we report that CD146 is...
- p63-microRNA feedback in keratinocyte senescence
[作者:Cervo, PRD; Lena, AM; Nicoloso, M; Rossi, S; Mancini, M; Zhou, HQ; Saintigny, G; Dellambra, E; Odorisio, T; Mahe, C; Calin, GA; Candi, E; Melino, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1133-1138 , 文章类型: Article,,卷期:2012年109-4]
- We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide miRNA profiling, and...
- Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNA(i)(Met) synthesis and systemic insulin signaling
[作者:Rideout, EJ; Marshall, L; Grewal, SS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1139-1144 , 文章类型: Article,,卷期:2012年109-4]
- The target-of-rapamycin pathway couples nutrient availability with tissue and organismal growth in metazoans. The key effectors underlying this growth are, however, unclear. Here we show that Maf1, a repressor of RNA pol...
- Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation
[作者:Sun, XF; Zhang, LQ; Xie, HR; Wan, HJ; Magella, B; Whitsett, JA; Dey, SK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1145-1150 , 文章类型: Article,,卷期:2012年109-4]
- A blastocyst will implant only when the uterus becomes receptive. Following attachment, luminal epithelial cells undergo degeneration at the site of the blastocyst. Although many genes critical for uterine receptivity ar...
- Detecting anthrax in the mail by coherent Raman microspectroscopy
[作者:Arora, R; Petrov, GI; Yakovlev, VV; Scully, MO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1151-1153 , 文章类型: Article,,卷期:2012年109-4]
- In this report, we show the collection of spatial information through a turbid medium by coherent Raman microspectroscopic imaging. In particular, the technique is capable of identifying anthrax endospores inside a seale...
- Underground leaves of Philcoxia trap and digest nematodes
[作者:Pereira, CG; Almenara, DP; Winter, CE; Fritsch, PW; Lambers, H; Oliveira, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1154-1158 , 文章类型: Article,,卷期:2012年109-4]
- The recently described genus Philcoxia comprises three species restricted to well lit and low-nutrient soils in the Brazilian Cerrado. The morphological and habitat similarities of Philcoxia to those of some carnivorous ...
- Microbial diversity determines the invasion of soil by a bacterial pathogen
[作者:van Elsas, JD; Chiurazzi, M; Mallon, CA; Elhottova, D; Kristufek, V; Salles, JF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1159-1164 , 文章类型: Article,,卷期:2012年109-4]
- Natural ecosystems show variable resistance to invasion by alien species, and this resistance can relate to the species diversity in the system. In soil, microorganisms are key components that determine life support func...
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