- Polyfunctional responses by human T cells result from sequential release of cytokines
[作者:Han, Q; Bagheri, N; Bradshaw, EM; Hafler, DA; Lauffenburger, DA; Love, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1607-1612 , 文章类型: Article,,卷期:2012年109-5]
- The release of cytokines by T cells defines a significant part of their functional activity in vivo, and their ability to produce multiple cytokines has been associated with beneficial immune responses. To date, time-int...
- Toll-like receptor 5 (TLR5), IL-1 beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing
[作者:Descamps, D; Le Gars, M; Balloy, V; Barbier, D; Maschalidi, S; Tohme, M; Chignard, M; Ramphal, R; Manoury, B; Sallenave, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1619-1624 , 文章类型: Article,,卷期:2012年109-5]
- A deficit in early clearance of Pseudomonas aeruginosa (P. aeruginosa) is crucial in nosocomial pneumonia and in chronic lung infections. Few studies have addressed the role of Toll-like receptors (TLRs), which are early...
- Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function
[作者:Zanin-Zhorov, A; Lin, JQ; Scher, J; Kumari, S; Blair, D; Hippen, KL; Blazar, BR; Abramson, SB; Lafaille, JJ; Dustin, ML,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1625-1630 , 文章类型: Article,,卷期:2012年109-5]
- Foxp3(+) CD4(+) CD25(high) regulatory T cell (Treg) suppression of inflammation depends on T-cell receptor-mediated Nuclear Factor of Activated T cells c1 (NFATc1) activation with reduced Akt activity. We investigated th...
- Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance
[作者:Papatriantafyllou, M; Moldenhauer, G; Ludwig, J; Tafuri, A; Garbi, N; Hollmann, G; Kublbeck, G; Klevenz, A; Schmitt, S; Pougialis, G; Niehrs, C; Grone, HJ; Hammerling, GJ; Arnold, B; Oelert, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1631-1636 , 文章类型: Article,,卷期:2012年109-5]
- In healthy individuals, T cells react against incoming pathogens, but remain tolerant to self-antigens, thereby preventing autoimmune reactions. CD4 regulatory T cells are major contributors in induction and maintenance ...
- Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment
[作者:Guzman-Rojas, L; Rangel, R; Salameh, A; Edwards, JK; Dondossola, E; Kim, YG; Saghatelian, A; Giordano, RJ; Kolonin, MG; Staquicini, FI; Koivunen, E; Sidman, RL; Arap, W; Pasqualini, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1637-1642 , 文章类型: Article,,卷期:2012年109-5]
- Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is of...
- Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression
[作者:Drake, JM; Graham, NA; Stoyanova, T; Sedghi, A; Goldstein, AS; Cai, HJ; Smith, DA; Zhang, H; Komisopoulou, E; Huang, JT; Graeber, TG; Witte, ON,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1643-1648 , 文章类型: Article,,卷期:2012年109-5]
- Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer. We demonstrate that castration-resistant prostate cancer (CRPC) in men exhibits increase...
- Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice
[作者:Moresi, V; Carrer, M; Grueter, CE; Rifki, OF; Shelton, JM; Richardson, JA; Bassel-Duby, R; Olson, EN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1649-1654 , 文章类型: Article,,卷期:2012年109-5]
- Maintenance of skeletal muscle structure and function requires efficient and precise metabolic control. Autophagy plays a key role in metabolic homeostasis of diverse tissues by recycling cellular constituents, particula...
- Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases
[作者:Rick, FG; Schally, AV; Szalontay, L; Block, NL; Szepeshazi, K; Nadji, M; Zarandi, M; Hohla, F; Buchholz, S; Seitz, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1655-1660 , 文章类型: Article,,卷期:2012年109-5]
- The management of castration-resistant prostate cancer (CRPC) presents a clinical challenge because of limitations in efficacy of current therapies. Novel therapeutic strategies for the treatment of CRPC are needed. Anta...
- Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)
[作者:Girard, M; Lariviere, R; Parfitt, DA; Deane, EC; Gaudet, R; Nossova, N; Blondeau, F; Prenosil, G; Vermeulen, EGM; Duchen, MR; Richter, A; Shoubridge, EA; Gehring, K; McKinney, RA; Brais, B; Chapple, JP; McPherson, PS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1661-1666 , 文章类型: Article,,卷期:2012年109-5]
- Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset neurological disease resulting frommutations in the SACS gene encoding sacsin, a 4,579-aa protein of unknown function. Originally id...
- Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
[作者:Zhang, CB; Wendel, AA; Keogh, MR; Harris, TE; Chen, J; Coleman, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1667-1672 , 文章类型: Article,,卷期:2012年109-5]
- Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains unknown. To determine the mechanism by which glycerolipids impa...
- IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
[作者:Lefrancais, E; Roga, S; Gautier, V; Gonzalez-de-Peredo, A; Monsarrat, B; Girard, JP; Cayrol, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1673-1678 , 文章类型: Article,,卷期:2012年109-5]
- Interleukin-33 (IL-33) (NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1 family, which has been linked to important diseases, including asthma, rheumatoid arthritis, ulcerative colitis, and cardiovascular...
- Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle
[作者:Jang, E; Albadawi, H; Watkins, MT; Edelman, ER; Baker, AB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1679-1684 , 文章类型: Article,,卷期:2012年109-5]
- Ischemia of the myocardium and lower limbs is a common consequence of arterial disease and a major source of morbidity and mortality in modernized countries. Inducing neovascularization for the treatment of ischemia is a...
- Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity
[作者:Goh, AM; Lim, CY; Chiam, PC; Li, L; Mann, MB; Mann, KM; Menendez, S; Lane, DP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1685-1690 , 文章类型: Article,,卷期:2012年109-5]
- The p53 transcription factor modulates gene expression programs that induce cell cycle arrest, senescence, or apoptosis, thereby preventing tumorigenesis. However, the mechanisms by which these fates are selected are unc...
- In-feed antibiotic effects on the swine intestinal microbiome
[作者:Looft, T; Johnson, TA; Allen, HK; Bayles, DO; Alt, DP; Stedtfeld, RD; Sul, WJ; Stedtfeld, TM; Chai, BL; Cole, JR; Hashsham, SA; Tiedje, JM; Stanton, TB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1691-1696 , 文章类型: Article,,卷期:2012年109-5]
- Antibiotics have been administered to agricultural animals for disease treatment, disease prevention, and growth promotion for over 50 y. The impact of such antibiotic use on the treatment of human diseases is hotly deba...
- Polar growth in the Alphaproteobacterial order Rhizobiales
[作者:Brown, PJB; de Pedro, MA; Kysela, DT; Van der Henst, C; Kim, J; De Bolle, X; Fuqua, C; Brun, YV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1697-1701 , 文章类型: Article,,卷期:2012年109-5]
- Elongation of many rod-shaped bacteria occurs by peptidoglycan synthesis at discrete foci along the sidewall of the cells. However, within the Rhizobiales, there are many budding bacteria, in which new cell growth is con...
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