- Twilight Zone Sponges from Guam Yield Theonellin Isocyanate and Psammaplysins I and J
[作者:Wright, AD; Schupp, PJ; Schror, JP; Engemann, A; Rohde, S; Kelman, D; de Voogd, N; Carroll, A; Motti, CA,期刊:Journal of natural products, 页码:502-506 , 文章类型: Article,,卷期:2012年75-3]
- From the organic extracts of two Guam sponges, Rhaphoxya sp. and Suberea sp., determined to have cytotoxic and chemopreventive activities, three new compounds, theonellin isocyanate (1) and psammaplysins I and J (5, 6), ...
- Induction of Apoptosis by 3-Amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via Modulation of MAPKs (p38 and c-Jun N-terminal Kinase) and c-Myc in HL-60 Human Leukemia Cells
[作者:Park, EJ; Kiselev, E; Conda-Sheridan, M; Cushman, M; Pezzuto, JM,期刊:Journal of natural products, 页码:378-384 , 文章类型: Article,,卷期:2012年75-3]
- Recently, we reported that 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (AM6-36), sharing structural similarity with naturally occurring isoquinolines, induced activities mediated by ret...
- Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
[作者:Pettit, GR; Rosenberg, HJ; Dixon, R; Knight, JC; Hamel, E; Chapuis, JC; Pettit, RK; Hogan, F; Sumner, B; Ain, KB; Trickey-Platt, B,期刊:Journal of natural products, 页码:385-393 , 文章类型: Article,,卷期:2012年75-3]
- Toward the objective of designing a structurally modified analogue of the combretastatin A-4 phosphate prodrug (1b) with the potential for increased specificity toward thyroid carcinoma, synthesis of a series of iodocomb...
- Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima
[作者:Whitson, EL; Sun, H; Thomas, CL; Henrich, CJ; Sayers, TJ; McMahon, JB; Griesinger, C; Mckee, TC,期刊:Journal of natural products, 页码:394-399 , 文章类型: Article,,卷期:2012年75-3]
- Barleria alluaudii and Diospyros maritima were both investigated as part of an ongoing search for synergistic TRAIL (tumor necrosis factor-alpha-related apoptosis-inducing ligand) sensitizers. As a result of this study, ...
- Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors
[作者:Francisco, W; Pivatto, M; Danuello, A; Regasini, LO; Baccini, LR; Young, MCM; Lopes, NP; Lopes, JLC; Bolzani, VS,期刊:Journal of natural products, 页码:408-413 , 文章类型: Article,,卷期:2012年75-3]
- As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4)...
- Library-Based Discovery and Characterization of Daphnane Diterpenes as Potent and Selective HIV Inhibitors in Daphne gnidium
[作者:Vidal, V; Potterat, O; Louvel, S; Hamy, F; Mojarrab, M; Sanglier, JJ; Klimkait, T; Hamburger, M,期刊:Journal of natural products, 页码:414-419 , 文章类型: Article,,卷期:2012年75-3]
- Despite the existence of an extended armamentarium of effective synthetic drugs to treat HIV, there is a continuing need for new potent and affordable drugs. Given the successful history of natural product based drug dis...
- Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.)
[作者:Herath, K; Jayasuriya, H; Zink, DL; Sigmund, J; Vicente, F; de la Cruz, M; Basilio, A; Bills, GF; Polishook, JD; Donald, R; Phillips, J; Goetz, M; Singh, SB,期刊:Journal of natural products, 页码:420-424 , 文章类型: Article,,卷期:2012年75-3]
- Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial infections, new antibiotics with new modes of action are needed. In...
- Symplocin A, a Linear Peptide from the Bahamian Cyanobacterium Symploca sp Configurational Analysis of N,N-Dimethylamino Acids by Chiral-Phase HPLC of Naphthacyl Esters
[作者:Molinski, TF; Reynolds, KA; Morinaka, BI,期刊:Journal of natural products, 页码:425-431 , 文章类型: Article,,卷期:2012年75-3]
- The absolute stereostructures of the components of symplocin A (3), a new N,N-dimethyl-terminated peptide from the Bahamian cyanobacterium Symploca sp., were assigned from spectroscopic analysis, including MS, 2D NMR, an...
- Dereplication, Residual Complexity, and Rational Naming: The Case of the Actaea Triterpenes
[作者:Qiu, F; Imai, A; McAlpine, JB; Lankin, DC; Burton, I; Karakach, T; Farnsworth, NR; Chen, SN; Pauli, GF,期刊:Journal of natural products, 页码:432-443 , 文章类型: Article,,卷期:2012年75-3]
- The genus Actaea (including Cimicifuga) has been the source of similar to 200 cycloartane triterpenes. While they are major bioactive constituents of complementary and alternative medicines, their structural similarity i...
- Isolation, Structure Elucidation, and Biological Evaluation of 16,23-Epoxycucurbitacin Constituents from Eleaocarpus chinensis
[作者:Pan, L; Yong, Y; Deng, Y; Lantvit, DD; Ninh, TN; Chai, H; de Blanco, EJC; Soejarto, DD; Swanson, SM; Kinghorn, AD,期刊:Journal of natural products, 页码:444-452 , 文章类型: Article,,卷期:2012年75-3]
- Eight new 16,23-epoxycucurbitacin derivatives, designated as elaeocarpucins A-H (1-8), and five known cucurbitacins (9-13) were isolated from the chloroform-soluble partitions of separate methanol extracts of the fruits ...
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