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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   A Unique Bicellar Nanosystem Combining Two Effects on Stratum Corneum Lipids [作者：Rodriguez, G; Cocera, M; Rubio, L; Lopez-Iglesias, C; Pons, R; de la Maza, A; Lopez, O,期刊：Molecular Pharmaceutics, 页码：482-491 , 文章类型： Article，,卷期：2012年9-3] In this work a new composition (dioleylphosphatidylcholine, DOPC, and dihexanoylphosphocholine, DHPC) is used to form the bicellar system and to evaluate their effect on stratum corneum (SC) lipids. Through this article,... In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate [作者：Abuasal, BS; Bolger, MB; Walker, DK; Kaddoumi, A,期刊：Molecular Pharmaceutics, 页码：492-504 , 文章类型： Article，,卷期：2012年9-3] The aim of this work was to extrapolate in vitro and preclinical animal data to simulate the pharmacokinetic parameters of UK-343,664, a P-glycoprotein (P-gp) and CYP3A4 substrate, in human. In addition, we aimed to deve... Mesoporous Silica Nanoparticles for Increasing the Oral Bioavailability and Permeation of Poorly Water Soluble Drugs [作者：Zhang, YZ; Wang, JC; Bai, XY; Jiang, TY; Zhang, Q; Wang, SL,期刊：Molecular Pharmaceutics, 页码：505-513 , 文章类型： Article，,卷期：2012年9-3] We investigate the effects of spherical mesoporous silica nanoparticles (MSNs) as an oral drug delivery system to improve the oral bioavailability of the model drug telmisartan (TEL) and examine their cellular uptake and... Enhanced Tumor Treatment Using Biofunctional Indocyanine Green-Containing Nanostructure by Intratumoral or Intravenous Injection [作者：Zheng, XH; Zhou, FF; Wu, BY; Chen, WR; Xing, D,期刊：Molecular Pharmaceutics, 页码：514-522 , 文章类型： Article，,卷期：2012年9-3] Indocyanine green (ICG) is a conventional dye that can be used in clinical near-infrared (NIR) imaging, and it is also an effective light absorber for laser-mediated photothermal therapy. However, applications of ICG wer... Membrane and Nuclear Permeabilization by Polymeric pDNA Vehicles: Efficient Method for Gene Delivery or Mechanism of Cytotoxicity? [作者：Grandinetti, G; Smith, AE; Reineke, TM,期刊：Molecular Pharmaceutics, 页码：523-538 , 文章类型： Article，,卷期：2012年9-3] The aim of this study is to compare the cytotoxicity mechanisms of linear PEI to two analogous polymers synthesized by our group: a hydroxyl-containing poly(L-tartaramidoamine) (T4) and a version containing an alkyl chai... Different Effect of Hydrogelation on Antifouling and Circulation Properties of Dextran-Iron Oxide Nanoparticles [作者：Karmali, PP; Chao, Y; Park, JH; Sailor, MJ; Ruoslahti, E; Esener, SC; Simberg, D,期刊：Molecular Pharmaceutics, 页码：539-545 , 文章类型： Article，,卷期：2012年9-3] Premature recognition and clearance of nanoparticulate imaging and therapeutic agents by macrophages in the tissues can dramatically reduce both the nanoparticle half-life and delivery to the diseased tissue. Grafting na... Modification of Crystallization Behavior in Drug/Polyethylene Glycol Solid Dispersions [作者：Zhu, Q; Harris, MT; Taylor, LS,期刊：Molecular Pharmaceutics, 页码：546-553 , 文章类型： Article，,卷期：2012年9-3] The crystallization kinetics of various active pharmaceutical ingredient/polyethylene glycol (API/PEG) solid dispersions has been investigated using wide-angle X-ray diffraction (XRD) and Raman spectroscopy. APIs with di... A New Strategy To Stabilize Oxytocin in Aqueous Solutions: II. Suppression of Cysteine-Mediated Intermolecular Reactions by a Combination of Divalent Metal Ions and Citrate [作者：Avanti, C; Permentier, HP; van Dam, A; Poole, R; Jiskoot, W; Frijlink, HW; Hinrichs, WLJ,期刊：Molecular Pharmaceutics, 页码：554-562 , 文章类型： Article，,卷期：2012年9-3] A series of studies have been conducted to develop a heat-stable liquid oxytocin formulation. Oxytocin degradation products have been identified including citrate adducts formed in a formulation with citrate buffer. In a... Critical Characteristics for Corticosteroid Solution Metered Dose Inhaler Bioequivalence [作者：Grainger, CI; Saunders, M; Buttini, F; Telford, R; Merolla, LL; Martin, GP; Jones, SA; Forbes, B,期刊：Molecular Pharmaceutics, 页码：563-569 , 文章类型： Article，,卷期：2012年9-3] Determining bioequivalence for solution pressurized metered dose inhalers (pMDI) is difficult because the critical characteristics of such products are poorly defined. The aim of this study was to elucidate the non-aerod... BDDCS Class Prediction for New Molecular Entities [作者：Broccatelli, F; Cruciani, G; Benet, LZ; Oprea, TI,期刊：Molecular Pharmaceutics, 页码：570-580 , 文章类型： Article，,卷期：2012年9-3] The Biopharmaceutics Drug Disposition Classification System (BDDCS) was successfully employed for predicting drug-drug interactions (DDIs) with respect to drug metabolizing enzymes (DMEs), drug transporters and their int... The Solubility-Permeability Interplay When Using Cosolvents for Solubilization: Revising the Way We Use Solubility-Enabling Formulations [作者：Miller, JM; Beig, A; Carr, RA; Webster, GK; Dahan, A,期刊：Molecular Pharmaceutics, 页码：581-590 , 文章类型： Article，,卷期：2012年9-3] We have recently reported the interplay between apparent aqueous solubility and intestinal membrane permeability, showing the trade-off between the two when using cyclodextrin- and surfactant-based systems as solubility-... A Novel Conjugated Agent between Dopamine and an A(2A) Adenosine Receptor Antagonist as a Potential Anti-Parkinson Multitarget Approach [作者：Dalpiaz, A; Cacciari, B; Vicentini, CB; Bortolotti, F; Spalluto, G; Federico, S; Pavan, B; Vincenzi, F; Borea, PA; Varani, K,期刊：Molecular Pharmaceutics, 页码：591-604 , 文章类型： Article，,卷期：2012年9-3] We propose a potential antiparkinsonian prodrug DP-L-A(2A)ANT (2) obtained by amidic conjugation of dopamine (1) via a succinic spacer to a new triazolo-triazine A(2A) adenosine receptor (AR) antagonist A(2A)ANT (3). The... Hydrophilic Prodrug Approach for Reduced Pigment Binding and Enhanced Transscleral Retinal Delivery of Celecoxib [作者：Malik, P; Kadam, RS; Cheruvu, NPS; Kompella, UB,期刊：Molecular Pharmaceutics, 页码：605-614 , 文章类型： Article，,卷期：2012年9-3] Transscleral retinal delivery of celecoxib, an anti-inflammatory and anti-VEGF agent, is restricted by its poor solubility and binding to the melanin pigment in choroid-RPE. The purpose of this study was to develop solub... Restoring Basal Planes of Graphene Oxides for Highly Efficient Loading and Delivery of beta-Lapachone [作者：Zheng, XT; Li, CM,期刊：Molecular Pharmaceutics, 页码：615-621 , 文章类型： Article，,卷期：2012年9-3] An efficient and biocompatible drug nanocarrier is essential for nanomedicines to realize their full therapeutic potential. Here, we investigate the loading of a selective and potent anticancer drug, beta-lapachone (beta... Protein G, Protein A and Protein A-Derived Peptides Inhibit the Agitation Induced Aggregation of IgG [作者：Zhang, J; Topp, EM,期刊：Molecular Pharmaceutics, 页码：622-628 , 文章类型： Article，,卷期：2012年9-3] Controlling and preventing aggregation is critical to the development of safe and effective antibody drug products. The studies presented here test the hypothesis that protein A and protein G inhibit the agitation-induce... P-Glycoprotein-Based Loperamide-Cyclosporine Drug Interaction at the Rat Blood-Brain Barrier: Prediction from In Vitro Studies and Extrapolation to Humans [作者：Hsiao, P; Unadkat, JD,期刊：Molecular Pharmaceutics, 页码：629-633 , 文章类型： Article，,卷期：2012年9-3] We have shown that the rat can quantitatively predict the verapamil-cyclopsorine A (CsA) drug drug interaction (DDI) at the human blood brain barrier (BBB). In addition, the potency (EC50) of CsA to inhibit rat BBB P-gp ...