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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共34条记录   Partial Biodistribution and Pharmacokinetics of Isoniazid and Rifabutin Following Pulmonary Delivery of Inhalable Microparticles to Rhesus Macaques [作者：Verma, RK; Mukker, JK; Singh, RSP; Kumar, K; Verma, PRP; Misra, A,期刊：Molecular Pharmaceutics, 页码：1011-1016 , 文章类型： Article，,卷期：2012年9-4] Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5, or 25 mg of each dru... Involvement of Ca2+ and ATP in Enhanced Gene Delivery by Bubble Liposomes and Ultrasound Exposure [作者：Omata, D; Negishi, Y; Yamamura, S; Hagiwara, S; Endo-Takahashi, Y; Suzuki, R; Maruyama, K; Nomizu, M; Aramaki, Y,期刊：Molecular Pharmaceutics, 页码：1017-1023 , 文章类型： Article，,卷期：2012年9-4] Recently, we reported the accelerated gene transfection efficiency of laminin-derived AG73-peptide-labeled polyethylene glycol-modified liposomes (AG73-PEG liposomes) and cell penetrating TAT-peptide labeled PEG liposome... Interaction of alpha-Synuclein and a Cell Penetrating Fusion Peptide with Higher Eukaryotic Cell Membranes Assessed by F-19 NMR [作者：Zigoneanu, IG; Pielak, GJ,期刊：Molecular Pharmaceutics, 页码：1024-1029 , 文章类型： Article，,卷期：2012年9-4] We show that fluorine NMR can be used to monitor the insertion and change in conformation of a F-19-labeled cell-penetrating peptide upon interacting with the cellular plasma membrane. alpha-Synuclein and a construct com... Advances in Biophysical and Bioanalytical Protein Characterization [作者：Laurence, JS,期刊：Molecular Pharmaceutics, 页码：695-695 , 文章类型： Editorial Material，,卷期：2012年9-4] Advancements in High Throughput Biophysical Technologies: Applications for Characterization and Screening during Early Formulation Development of Monoclonal Antibodies [作者：Samra, HS; He, F,期刊：Molecular Pharmaceutics, 页码：696-707 , 文章类型： Review，,卷期：2012年9-4] The formulation development of monoclonal antibodies is extremely challenging, due to the diversity and complexity contained within this class of molecules. The physical and chemical properties of a monoclonal antibody d... Antimicrobial Properties of Amyloid Peptides [作者：Kagan, BL; Jang, H; Capone, R; Arce, FT; Ramachandran, S; Lal, R; Nussinov, R,期刊：Molecular Pharmaceutics, 页码：708-717 , 文章类型： Review，,卷期：2012年9-4] More than two dozen clinical syndromes known as amyloid diseases are characterized by the buildup of extended insoluble fibrillar deposits in tissues. These amorphous Congo red staining deposits known as amyloids exhibit... Localized Hydration in Lyophilized Myoglobin by Hydrogen-Deuterium Exchange Mass Spectrometry. 1. Exchange Mapping [作者：Sophocleous, AM; Zhang, J; Topp, EM,期刊：Molecular Pharmaceutics, 页码：718-726 , 文章类型： Article，,卷期：2012年9-4] The local effects of hydration on myoglobin (Mb) in solid matrices containing mannitol or sucrose (1:1 w/w, protein:additive) were mapped using hydrogen-deuterium exchange with mass spectrometric analysis (HDX-MS) at 5 d... Localized Hydration in Lyophilized Myoglobin by Hydrogen-Deuterium Exchange Mass Spectrometry. 2. Exchange Kinetics [作者：Sophocleous, AM; Topp, EM,期刊：Molecular Pharmaceutics, 页码：727-733 , 文章类型： Article，,卷期：2012年9-4] Solid-state hydrogen-deuterium exchange with mass spectrometric analysis (ssHDX) is a promising method for characterizing proteins in amorphous solids. Though analysis of HDX kinetics is informative and well-established ... Mapping Site-Specific Changes That Affect Stability of the N-Terminal Domain of Calmodulin [作者：Krause, ME; Martin, TT; Laurence, JS,期刊：Molecular Pharmaceutics, 页码：734-743 , 文章类型： Article，,卷期：2012年9-4] Biophysical tools have been invaluable in formulating therapeutic proteins. These tools characterize protein stability rapidly in a variety of solution conditions, but in general, the techniques lack the ability to disce... Solution pH That Minimizes Self-Association of Three Monoclonal Antibodies Is Strongly Dependent on Ionic Strength [作者：Sule, SV; Cheung, JK; Antochshuk, V; Bhalla, AS; Narasimhan, C; Baisdell, S; Shameem, M; Tessier, PM,期刊：Molecular Pharmaceutics, 页码：744-751 , 文章类型： Article，,卷期：2012年9-4] Monoclonal antibodies display highly variable solution properties such as solubility and viscosity at elevated concentrations (>50 mg/mL), which complicates antibody formulation and delivery. To understand this complex b... Bicelles at Low Concentrations [作者：Lu, ZW; Van Horn, WD; Chen, J; Mathew, S; Zent, R; Sanders, CR,期刊：Molecular Pharmaceutics, 页码：752-761 , 文章类型： Article，,卷期：2012年9-4] Bilayered detergent-lipid assemblies known as bicelles have been widely used as model membranes in structural biological studies and are being explored for wider applications, including pharmaceutical use. Most studies t... Effect of PEGylation on Protein Hydrodynamics [作者：Gokarn, YR; McLean, M; Laue, TM,期刊：Molecular Pharmaceutics, 页码：762-773 , 文章类型： Article，,卷期：2012年9-4] We studied the effect of PEGylation on protein hydrodynamic behavior using hen egg-white lysozyme (HEWL) as a model protein. HEWL was PEGylated with a linear, 20 kDa PEG using reductive amination to produce PEG1-, PEG2-,... Effect of pH and Light on Aggregation and Conformation of an IgG1 mAb [作者：Mason, BI; Schoneich, C; Kerwin, BA,期刊：Molecular Pharmaceutics, 页码：774-790 , 文章类型： Article，,卷期：2012年9-4] During the purification process, monoclonal antibodies may be exposed to parts of UV-C (200 to 290 nm), UV-B (290 to 320 nm) and visible light (400 to 760 nm) under a variety of buffer and pH conditions. Together, these ... The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions [作者：Yadav, S; Laue, TM; Kalonia, DS; Singh, SN; Shire, SJ,期刊：Molecular Pharmaceutics, 页码：791-802 , 文章类型： Article，,卷期：2012年9-4] The present work investigates the influence of electrostatic surface potential distribution of monoclonal antibodies (MAbs) on intermolecular interactions and viscosity. Electrostatic models suggest MAb-1 has a less unif... Oxidation of Human Growth Hormone by Oxygen-Centered Radicals: Formation of Leu-101 Hydroperoxide and Tyr-103 Oxidation Products [作者：Steinmann, D; Ji, JA; Wang, YJ; Schoneich, C,期刊：Molecular Pharmaceutics, 页码：803-814 , 文章类型： Article，,卷期：2012年9-4] Human growth hormone (hGH) was exposed to oxygen-centered radicals generated through the thermolysis of AAPH in the presence of dioxygen. Such conditions mimic oxidative processes which protein pharmaceuticals can encoun... Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine [作者：Waldmann, S; Almukainzi, M; Bou-Chacra, NA; Amidon, GL; Lee, BJ; Feng, JF; Kanfer, I; Zuo, JZ; Wei, H; Bolger, MB; Lobenberg, R,期刊：Molecular Pharmaceutics, 页码：815-822 , 文章类型： Article，,卷期：2012年9-4] The aim of this study was to classify some markers of common herbs used in Western medicine according to the Biopharmaceutical Classification System (BCS). The BCS is a scientific approach to classify drug substances bas...