- Modulation of the Tumor Microvasculature by Phosphoinositide-3 Kinase Inhibition Increases Doxorubicin Delivery In Vivo
[作者：Qayum, N; Im, J; Stratford, MR; Bernhard, EJ; McKenna, WG; Muschel, RJ,期刊：Clinical Cancer Research, 页码：161-169 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: Because effective drug delivery is often limited by inadequate vasculature within the tumor, the ability to modulate the tumor microenvironment is one strategy that may achieve better drug distribution. We have ...
- Antitumor Activity of NVP-BKM120-A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells
[作者：Koul, D; Fu, J; Shen, RJ; LaFortune, TA; Wang, SZ; Tiao, NY; Kim, YW; Liu, JL; Ramnarian, D; Yuan, Y; Garcia-Echevrria, C; Maira, SM; Yung, WKA,期刊：Clinical Cancer Research, 页码：184-195 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: The aim of this study was to show preclinical efficacy and clinical development potential of NVP-BKM120, a selective pan class I phosphatidylinositol-3 kinase (PI3K) inhibitor in human glioblastoma (GBM) cells i...
- Validation of Genetic Sequence Variants as Prognostic Factors in Early-Stage Head and Neck Squamous Cell Cancer Survival
[作者：Azad, AK; Bairati, I; Samson, E; Cheng, DX; Mirshams, M; Qiu, X; Savas, S; Waldron, J; Wang, CS; Goldstein, D; Xu, W; Meyer, F; Liu, G,期刊：Clinical Cancer Research, 页码：196-206 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: From the published literature, we identified 23 germ line sequence variants in 17 genes from hypothesis-generating studies that were associated with prognosis of head and neck cancer, including sequence variants...
- Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes
[作者：Tafreshi, NK; Bui, MM; Bishop, K; Lloyd, MC; Enkemann, SA; Lopez, AS; Abrahams, D; Carter, BW; Vagner, J; Gobmyer, SR; Gillies, RJ; Morse, DL,期刊：Clinical Cancer Research, 页码：207-219 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: To develop targeted molecular imaging probes for the noninvasive detection of breast cancer lymph node metastasis. Experimental Design: Six cell surface or secreted markers were identified by expression profilin...
- Early [F-18]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung
[作者：Takahashi, R; Hirata, H; Tachibana, I; Shimosegawa, E; Inoue, A; Nagatomo, I; Takeda, Y; Kida, H; Goya, S; Kijima, T; Yoshida, M; Kumagai, T; Kumanogoh, A; Okumura, M; Hatazawa, J; Kawase, I,期刊：Clinical Cancer Research, 页码：220-228 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: Positron emission tomography (PET) with [F-18]fluorodeoxyglucose (FDG) is increasingly used in early assessment of tumor response after chemotherapy. We investigated whether a change in [F-18]FDG uptake at 2 day...
- Lymphatic Invasion Is Independently Prognostic of Metastasis in Primary Cutaneous Melanoma
[作者：Xu, XW; Chen, LJ; Guerry, D; Dawson, PR; Hwang, WT; VanBelle, P; Elder, DE; Zhang, PJ; Ming, ME; Schuchter, L; Gimotty, PA,期刊：Clinical Cancer Research, 页码：229-237 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor. Experimental Design: This study included 251 patients w...
- In Vivo Positron Emission Tomography Imaging of Protease Activity by Generation of a Hydrophobic Product from a Noninhibitory Protease Substrate
[作者：Chuang, CH; Chuang, KH; Wang, HE; Roffler, SR; Shiea, JT; Tzou, SC; Cheng, TC; Kao, CH; Wu, SY; Tseng, WL; Cheng, CM; Hou, MF; Wang, JM; Cheng, TL,期刊：Clinical Cancer Research, 页码：238-247 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: To develop an imaging technology for protease activities in patients that could help in prognosis prediction and in design of personalized, protease-based inhibitors and prodrugs for targeted therapy. Experiment...
- A Phase I Weekly Dosing Study of Brentuximab Vedotin in Patients with Relapsed/Refractory CD30-Positive Hematologic Malignancies
[作者：Fanale, MA; Forero-Torres, A; Rosenblatt, JD; Advani, RH; Franklin, AR; Kennedy, DA; Han, TH; Sievers, EL; Bartlett, NL,期刊：Clinical Cancer Research, 页码：248-255 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: The antibody-drug conjugate (ADC) brentuximab vedotin comprises a CD30-directed antibody covalently attached to the potent antimicrotubule agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Th...
- Achieving Sufficient Accrual to Address the Primary Endpoint in Phase III Clinical Trials from US Cooperative Oncology Groups
[作者：Schroen, AT; Petroni, GR; Wang, HK; Thielen, MJ; Gray, R; Benedetti, J; Wang, XFF; Sargent, DJ; Wickerham, DL; Cronin, W; Djulbegovic, B; Slingluff, CL,期刊：Clinical Cancer Research, 页码：256-262 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: Assessing impact of poor accrual on premature trial closure requires a relevant metric. We propose defining accrual sufficiency on apparent ability to address primary endpoints (PE) rather than attaining accrual...
- Skin Tumors Induced by Sorafenib; Paradoxic RAS-RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1
[作者：Arnault, JP; Mateus, C; Escudier, B; Tomasic, G; Wechsler, J; Hollville, E; Soria, JC; Malka, D; Sarasin, A; Larcher, M; Andre, J; Kamsu-Kom, N; Boussemart, L; Lacroix, L; Spatz, A; Eggermont, AM; Druillennec, S; Vagner, S; Eychene, A; Dumaz, N; Robert, C,期刊：Clinical Cancer Research, 页码：263-272 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: The emergence of skin tumors in patients treated with sorafenib or with more recent BRAF inhibitors is an intriguing and potentially serious event. We carried out a clinical, pathologic, and molecular study of s...
- Concurrent Temozolomide and Dose-Escalated Intensity-Modulated Radiation Therapy in Newly Diagnosed Glioblastoma
[作者：Tsien, CI; Brown, D; Normolle, D; Schipper, M; Piert, M; Junck, L; Heth, J; Gomez-Hassan, D; Ten Haken, RK; Chenevert, T; Cao, Y; Lawrence, T,期刊：Clinical Cancer Research, 页码：273-279 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients with newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS...
- Molecular Determinants of Retinoic Acid Sensitivity in Pancreatic Cancer
[作者：Gupta, S; Pramanik, D; Mukherjee, R; Campbell, NR; Elumalai, S; de Wilde, RF; Hong, SM; Goggins, MG; De Jesus-Acosta, A; Laheru, D; Maitra, A,期刊：Clinical Cancer Research, 页码：280-289 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: To identify a predictive molecular "signature" for sensitivity to retinoic acid in pancreatic cancer. Experimental Design: Fourteen patient-derived, low-passage pancreatic ductal adenocarcinoma (PDAC) lines with...
- TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
[作者：Skinner, HD; Sandulache, VC; Ow, TJ; Meyn, RE; Yordy, JS; Beadle, BM; Fitzgerald, AL; Giri, U; Ang, KK; Myers, JN,期刊：Clinical Cancer Research, 页码：290-300 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this study, we use a classification of TP53...
- Prognostic Significance of Plasma Osteopontin in Patients with Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Treated on TROG 02.02 Phase III Trial
[作者：Lim, AM; Rischin, D; Fisher, R; Cao, HB; Kwok, K; Truong, D; McArthur, GA; Young, RJ; Giaccia, A; Peters, L; Le, QT,期刊：Clinical Cancer Research, 页码：301-307 , 文章类型： Article，,卷期：2012年18-1]
- Purpose: High plasma osteopontin (OPN) levels have been reported to be an adverse prognostic factor in head and neck squamous cell carcinomas (HNSCC), correlate with tumor hypoxia, and be predictive of benefit from hypox...
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