- Activation of beta-Catenin Signaling in Androgen Receptor-Negative Prostate Cancer Cells
[作者：Wan, XH; Liu, J; Lu, JF; Tzelepi, V; Yang, J; Starbuck, MW; Diao, LX; Wang, J; Efstathiou, E; Vazquez, ES; Troncoso, P; Maity, SN; Navone, NM,期刊：Clinical Cancer Research, 页码：726-736 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: To study Wnt/beta-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the beta-catenin-androgen receptor (AR) interaction. Experimental Design: We carried out beta-c...
- MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer
[作者：Migliore, C; Martin, V; Leoni, VP; Restivo, A; Atzori, L; Petrelli, A; Isella, C; Zorcolo, L; Sarotto, I; Casula, G; Comoglio, PM; Columbano, A; Giordano, S,期刊：Clinical Cancer Research, 页码：737-747 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: MET, the tyrosine kinase receptor for hepatocyte growth factor, is frequently overexpressed in colon cancers with high metastatic tendency. We aimed to evaluate the role of its negative regulators, miR-1 and miR...
- Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways
[作者：Shukla, N; Ameur, N; Yilmaz, I; Nafa, K; Lau, CY; Marchetti, A; Borsu, L; Barr, FG; Ladanyi, M,期刊：Clinical Cancer Research, 页码：748-757 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: In contrast to the numerous broad screens for oncogene mutations in adult cancers, few such screens have been conducted in pediatric solid tumors. To identify novel mutations and potential therapeutic targets in...
- Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
[作者：Sun, JD; Liu, Q; Wang, JL; Ahluwalia, D; Ferraro, D; Wang, Y; Duan, JX; Ammons, WS; Curd, JG; Matteucci, MD; Hart, CP,期刊：Clinical Cancer Research, 页码：758-770 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug of the cytotoxin bromo-isophosp...
- Omental Adipose Tissue-Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors
[作者：Klopp, AH; Zhang, Y; Solley, T; Amaya-Manzanares, F; Marini, F; Andreeff, M; Debeb, B; Woodward, W; Schmandt, R; Broaddus, R; Lu, K; Kolonin, MG,期刊：Clinical Cancer Research, 页码：771-782 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Adipose tissue contains a population of tumor-tropic mesenchymal progenitors, termed adipose stromal cells (ASC), which engraft in neighboring tumors to form supportive tumor stroma. We hypothesized that intra-a...
- Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
[作者：Lucas, KM; Mohana-Kumaran, N; Lau, D; Zhang, XD; Hersey, P; Huang, DC; Weninger, W; Haass, NK; Allen, JD,期刊：Clinical Cancer Research, 页码：783-795 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Inhibiting antiapoptotic BCL-2 and its relatives is an attractive strategy for sensitizing lymphoid malignancies to drugs but...
- Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
[作者：Tonelli, R; McIntyre, A; Camerin, C; Walters, ZS; Di Leo, K; Selfe, J; Purgato, S; Missiaglia, E; Tortori, A; Renshaw, J; Astolfi, A; Taylor, KR; Serravalle, S; Bishop, R; Nanni, C; Valentijn, LJ; Faccini, A; Leuschners, I; Formica, S; Reis, JS; Ambrosini, V; Thway, K; Franzoni, M; Summersgill, B; Marchelli, R; Hrelia, P; Cantelli-Forti, G; Fanti, S; Corradini, R; Pession, A; Shipley, J,期刊：Clinical Cancer Research, 页码：796-807 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Rhabdomyosarcomas are a major cause of cancer death in children, described with MYCN amplification and, in the alveolar subtype, transcription driven by the PAX3-FOXO1 fusion protein. Our aim was to determine th...
- Methylated RASSF1a Is the First Specific DNA Marker for Minimal Residual Disease Testing in Neuroblastoma
[作者：Stutterheim, J; Ichou, FA; den Ouden, E; Versteeg, R; Caron, HN; Tytgat, GAM; van der Schoot, CE,期刊：Clinical Cancer Research, 页码：808-814 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: PCR-based detection of minimal residual disease (MRD) in neuroblastoma (NB) is presently based on NB-specific transcripts. However, the expression of these targets varies between patients and upon treatment, and...
- External Validation of Diagnostic Models to Estimate the Risk of Malignancy in Adnexal Masses
[作者：Van Holsbeke, C; Van Calster, B; Bourne, T; Ajossa, S; Testa, AC; Guerriero, S; Fruscio, R; Lissoni, AA; Czekierdowski, A; Savelli, L; Van Huffel, S; Valentin, L; Timmerman, D,期刊：Clinical Cancer Research, 页码：815-825 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: To externally validate and compare the performance of previously published diagnostic models developed to predict malignancy in adnexal masses. Experimental Design: We externally validated the diagnostic perform...
- Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors
[作者：Lagarde, P; Perot, G; Kauffmann, A; Brulard, C; Dapremont, V; Hostein, I; Neuville, A; Wozniak, A; Sciot, R; Schoffski, P; Aurias, A; Coindre, JM; Debiec-Rychter, M; Chibon, F,期刊：Clinical Cancer Research, 页码：826-838 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal tumors (GIST) is well established, but the genetic basis of GIST metastasis is poorly understood. We recently published a...
- Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer
[作者：Kimura, RH; Teed, R; Hackel, BJ; Pysz, MA; Chuang, CZ; Sathirachinda, A; Willmann, JK; Gambhir, SS,期刊：Clinical Cancer Research, 页码：839-849 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Detection of pancreatic cancer remains a high priority and effective diagnostic tools are needed for clinical applications. Many cancer cells overexpress integrin alpha(v)beta(6), a cell surface receptor being e...
- Tumor Infiltration by T Lymphocytes Expressing Chemokine Receptor 7 (CCR7) Is Predictive of Favorable Outcome in Patients with Advanced Colorectal Carcinoma
[作者：Correale, P; Rotundo, MS; Botta, C; Del Vecchio, MT; Ginanneschi, C; Licchetta, A; Conca, R; Apollinari, S; De Luca, F; Tassone, P; Tagliaferri, P,期刊：Clinical Cancer Research, 页码：850-857 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: An efficient adaptive immunity is critical for a longer survival in cancer. We investigated the prognostic value of tumor infiltration by CD8(+) T cells expressing the chemokine-receptor-7 (T-ccr7) and the corre...
- A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction
[作者：Le, DT; Brockstedt, DG; Nir-Paz, R; Hampl, J; Mathur, S; Nemunaitis, J; Sterman, DH; Hassan, R; Lutz, E; Moyer, B; Giedlin, M; Louis, JL; Sugar, EA; Pons, A; Cox, AL; Levine, J; Murphy, AL; Illei, P; Dubensky, TW; Eiden, JE; Jaffee, EM; Laheru, DA,期刊：Clinical Cancer Research, 页码：858-868 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Listeria monocytogenes (Lm)-based vaccines stimulate both innate and adaptive immunity. ANZ-100 is a live-attenuated Lm strain (Lm Delta actA/Delta inlB). Uptake by phagocytes in the liver results in local infla...
- Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer
[作者：Steg, AD; Bevis, KS; Katre, AA; Ziebarth, A; Dobbin, ZC; Alvarez, RD; Zhang, K; Conner, M; Landen, CN,期刊：Clinical Cancer Research, 页码：869-881 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells (CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex vivo models. However, whether these populations ...
- Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer
[作者：de Weger, VA; Turksma, AW; Voorham, QJM; Euler, Z; Bril, H; van den Eertwegh, AJ; Bloemena, E; Pinedo, HM; Vermorken, JB; van Tinteren, H; Meijer, GA; Hooijberg, E,期刊：Clinical Cancer Research, 页码：882-889 , 文章类型： Article，,卷期：2012年18-3]
- Purpose: Active specific immunotherapy (AS!) consisting of an autologous tumor cell vaccine given as adjuvant treatment has been shown to improve recurrence-free survival of patients with colon cancer. The aim of the cur...
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