- Statistical Issues and Recommendations for Noninferiority Trials in Oncology: A Systematic Review
[作者:Tanaka, S; Kinjo, Y; Kataoka, Y; Yoshimura, K; Teramukai, S,期刊:Clinical Cancer Research, 页码:1837-1847 , 文章类型: Review,,卷期:2012年18-7]
- To provide an overview of noninferiority trials in oncology with a special emphasis on methodologic issues, we conducted a systematic review of randomized trials assessing noninferiority of antineoplastic treatments. We ...
- Abiraterone in Prostate Cancer: A New Angle to an Old Problem
[作者:Stein, MN; Goodin, S; DiPaola, RS,期刊:Clinical Cancer Research, 页码:1848-1854 , 文章类型: Article,,卷期:2012年18-7]
- Abiraterone acetate is an orally administered potent inhibitor of cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17), which is essential for synthesis of testosterone from cholesterol. Although decreasing ser...
- Immune Thrombocytopenia in Patients with Chronic Lymphocytic Leukemia Is Associated with Stereotyped B-cell Receptors
[作者:Visco, C; Maura, F; Tuana, G; Agnelli, L; Lionetti, M; Fabris, S; Novella, E; Giaretta, I; Reda, G; Barcellini, W; Baldini, L; Neri, A; Rodeghiero, F; Cortelezzi, A,期刊:Clinical Cancer Research, 页码:1870-1878 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: To assess biologic features related to the development of immune thrombocytopenia (ITP) in patients with chronic lymphocytic leukemia (CLL). Experimental Design: We retrospectively analyzed 463 patients with CLL...
- MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
[作者:Birner, P; Beer, A; Vinatzer, U; Stary, S; Hoftberger, R; Nirtl, N; Wrba, F; Streubel, B; Schoppmann, SF,期刊:Clinical Cancer Research, 页码:1879-1887 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: ETV1 has been proposed to be activated by KIT mutations in gastrointestinal stromal tumors (GIST). The aim of the study was to evaluate the clinical role of ETV1 and associated proteins in GIST. Experimental Des...
- Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress-Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response
[作者:Manni, S; Brancalion, A; Tubi, LQ; Colpo, A; Pavan, L; Cabrelle, A; Ave, E; Zaffino, F; Di Maira, G; Ruzzene, M; Adami, F; Zambello, R; Pitari, MR; Tassone, P; Pinna, LA; Gurrieri, C; Semenzato, G; Piazza, F,期刊:Clinical Cancer Research, 页码:1888-1900 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Protein kinase CK2 promotes multiple myeloma cell growth by regulating critical signaling pathways. CK2 also modulates proper HSP90-dependent client protein folding and maturation by phosphorylating its co-chape...
- Glioblastoma Stem-like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration
[作者:Schulte, A; Gunther, HS; Martens, T; Zapf, S; Riethdorf, S; Wulfing, C; Stoupiec, M; Westphal, M; Lamszus, K,期刊:Clinical Cancer Research, 页码:1901-1913 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Despite the high incidence of epidermal growth factor receptor (EGFR) gene amplification and rearrangement in glioblastomas, no suitable cell line exists that preserves these alterations in vitro and is tumorige...
- L1 Cell Adhesion Molecule Promotes Tumorigenicity and Metastatic Potential in Non-Small Cell Lung Cancer
[作者:Hai, J; Zhu, CQ; Bandarchi, B; Wang, YH; Navab, R; Shepherd, FA; Jurisica, I; Tsao, MS,期刊:Clinical Cancer Research, 页码:1914-1924 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Non-small cell lung cancer (NSCLC) is a highly metastatic cancer with limited treatment options, thus requiring development of novel targeted therapies. Our group previously identified L1 cell adhesion molecule ...
- Immune Suppression in Premalignant Respiratory Papillomas: Enriched Functional CD4(+)Foxp3(+) Regulatory T Cells and PD-1/PD-L1/L2 Expression
[作者:Hatam, LJ; DeVoti, JA; Rosenthal, DW; Lam, F; Abramson, AL; Steinberg, BM; Bonagura, VR,期刊:Clinical Cancer Research, 页码:1925-1935 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Respiratory papillomas, caused by human papillomaviruses types 6 and 11 (HPV6/11), are premalignant lesions with potential for malignant conversion. The cytokine and chemokine micromilieu of papillomas is T(H)2-...
- Integrative Genomics Identified RFC3 As an Amplified Candidate Oncogene in Esophageal Adenocarcinoma
[作者:Lockwood, WW; Thu, KL; Lin, L; Pikor, LA; Chari, R; Lam, WL; Beer, DG,期刊:Clinical Cancer Research, 页码:1936-1946 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Esophageal adenocarcinoma (EAC) is a lethal malignancy that can develop from the premalignant condition, Barrett's esophagus (BE). Currently, there are no validated simple methods to predict which patients will ...
- Frequency of Driver Mutations in Lung Adenocarcinoma from Female Never-Smokers Varies with Histologic Subtypes and Age at Diagnosis
[作者:Zhang, Y; Sun, YH; Pan, YJ; Li, CG; Shen, L; Li, Y; Luo, XY; Ye, T; Wang, R; Hu, HC; Li, H; Wang, L; Pao, W; Chen, HQ,期刊:Clinical Cancer Research, 页码:1947-1953 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Our previous study revealed that 90% [47 of 52; 95% confidence interval (CI), 0.79-0.96] of Chinese never-smokers with lung adenocarcinoma harbor known oncogenic driver mutations in just four genes EGFR, ALK, HE...
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