- Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo
[作者:Xia, W; Wang, PJ; Lin, C; Li, ZQ; Gao, XL; Wang, GL; Zhao, XH,期刊:Journal of controlled release, 页码:427-436 , 文章类型: Article,,卷期:2012年157-3]
- One new siRNA sequence was found efficient for human telomerase reverse transcriptase (hTERT) gene silencing in vitro in five types of human cancer cells. Then, a biodegradable polyethylenimine containing multiple disulf...
- Erythropoietin gene delivery using an arginine-grafted bioreducible polymer system
[作者:Nam, HY; Lee, Y; Lee, M; Shin, SK; Kim, TI; Kim, SW; Bull, DA,期刊:Journal of controlled release, 页码:437-444 , 文章类型: Article,,卷期:2012年157-3]
- Erythropoietin (EPO) plays a key regulatory role in the formation of new red blood cells (RBCs). Erythropoietin may also have a role as a therapeutic agent to counteract ischemic injury in neural, cardiac and endothelial...
- A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles
[作者:Mert, O; Lai, SK; Ensign, L; Yang, M; Wang, YY; Wood, J; Hanes, J,期刊:Journal of controlled release, 页码:455-460 , 文章类型: Article,,卷期:2012年157-3]
- Mucosal surfaces are protected by a highly viscoelastic and adhesive mucus layer that traps most foreign particles, including conventional drug and gene carriers. Trapped particles are eliminated on the order of seconds ...
- Imatinib-ULS-lysozyme: A proximal tubular cell-targeted conjugate of imatinib for the treatment of renal diseases
[作者:Dolman, MEM; van Dorenmalen, KMA; Pieters, EHE; Lacombe, M; Pato, J; Storm, G; Hennink, WE; Kok, RJ,期刊:Journal of controlled release, 页码:461-468 , 文章类型: Article,,卷期:2012年157-3]
- The anticancer drug imatinib is an inhibitor of the platelet-derived growth factor receptor (PDGFR) kinases, which are involved in the pathogenesis of fibrotic diseases. In the current study we investigated the delivery ...
- Development of a biodegradable nanoparticle platform for sildenafil: Formulation optimization by factorial design analysis combined with application of charge-modified branched polyesters
[作者:Beck-Broichsitter, M; Schmehl, T; Gessler, T; Seeger, W; Kissel, T,期刊:Journal of controlled release, 页码:469-477 , 文章类型: Article,,卷期:2012年157-3]
- Biodegradable nanoparticles have gained tremendous attraction as carriers for controlled drug delivery to the lung. Despite numerous advances in the field, e. g. development of suitable methods for pulmonary administrati...
|