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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression [作者：Yang, J; Staples, O; Thomas, LW; Briston, T; Robson, M; Poon, E; Simoes, ML; El-Emir, E; Buffa, FM; Ahmed, A; Annear, NP; Shukla, D; Pedley, BR; Maxwell, PH; Harris, AL; Ashcroft, M,期刊：Journal of clinical investigation, 页码：600-611 , 文章类型： Article，,卷期：2012年122-2] Increased expression of the regulatory subunit of HIFs (HIF-1 alpha or HIF-2 alpha) is associated with metabolic adaptation, angiogenesis, and tumor progression. Understanding how HIFs are regulated is of intense interes... CBX7 is a tumor suppressor in mice and humans [作者：Forzati, F; Federico, A; Pallante, P; Abbate, A; Esposito, F; Malapelle, U; Sepe, R; Palma, G; Troncone, G; Scarfo, M; Arra, C; Fedele, M; Fusco, A,期刊：Journal of clinical investigation, 页码：612-623 , 文章类型： Article，,卷期：2012年122-2] The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role of this protein in carcinogenesis remains unclear. To shed light on this issue, we genera... CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression [作者：Schurch, C; Riether, C; Matter, MS; Tzankov, A; Ochsenbein, AF,期刊：Journal of clinical investigation, 页码：624-638 , 文章类型： Article，,卷期：2012年122-2] Chronic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early progenitor cells that gives rise to the oncogenic BCR/ABL fusion protein. Clinically, CML has a chronic phase tha... Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice [作者：Collins, MA; Bednar, F; Zhang, YQ; Brisset, JC; Galban, S; Galban, CJ; Rakshit, S; Flannagan, KS; Adsay, NV; di Magliano, MP,期刊：Journal of clinical investigation, 页码：639-653 , 文章类型： Article，,卷期：2012年122-2] Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRAS(G12D), that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcin... Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine [作者：Jing, LC; Haas, J; Chong, TM; Bruckner, JJ; Dann, GC; Dong, LC; Marshak, JO; McClurkan, CL; Yamamoto, TN; Bailer, SM; Laing, KJ; Wald, A; Verjans, GMGM; Koelle, DM,期刊：Journal of clinical investigation, 页码：654-673 , 文章类型： Article，,卷期：2012年122-2] Herpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections, it can also cause permanent brain damage and blindness. There is currently no HSV-1 vaccine. An effective vaccine must stimula... Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease [作者：George, B; Verma, R; Soofi, AA; Garg, P; Zhang, JD; Park, TJ; Giardino, L; Ryzhova, L; Johnstone, DB; Wong, H; Nihalani, D; Salant, DJ; Hanks, SK; Curran, T; Rastaldi, MP; Holzman, LB,期刊：Journal of clinical investigation, 页码：674-692 , 文章类型： Article，,卷期：2012年122-2] The morphology of healthy podocyte foot processes is necessary for maintaining the characteristics of the kidney filtration barrier. In most forms of glomerular disease, abnormal filter barrier function results when podo... Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice [作者：Grenz, A; Bauerle, JD; Dalton, JH; Ridyard, D; Badulak, A; Tak, E; McNamee, EN; Clambey, E; Moldovan, R; Reyes, G; Klawitter, J; Ambler, K; Magee, K; Christians, U; Brodsky, KS; Ravid, K; Choi, DS; Wen, JM; Lukashev, D; Blackburn, MR; Osswald, H; Coe, IR; Nurnberg, B; Haase, VH; Xia, Y; Sitkovsky, M; Eltzschig, HK,期刊：Journal of clinical investigation, 页码：693-710 , 文章类型： Article，,卷期：2012年122-2] A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) - a life-threatening conditio... Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing [作者：Ishida, Y; Kimura, A; Kuninaka, Y; Inui, M; Matsushima, K; Mukaida, N; Kondo, T,期刊：Journal of clinical investigation, 页码：711-721 , 文章类型： Article，,卷期：2012年122-2] BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in tissue repair and tumorigenesis. EPCs migrate from BM to tissues via the bloodstream, but specific chemotactic cues have... Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency [作者：Kawamura, T; Ogawa, Y; Nakamura, Y; Nakamizo, S; Ohta, Y; Nakano, H; Kabashima, K; Katayama, L; Koizumi, S; Kodama, T; Nakao, A; Shimada, S,期刊：Journal of clinical investigation, 页码：722-732 , 文章类型： Article，,卷期：2012年122-2] Zinc deficiency can be an inherited disorder, in which case it is known as acrodermatitis enteropathica (AE), or an acquired disorder caused by low dietary intake of zinc. Even though zinc deficiency diminishes cellular ... RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice [作者：Lapinski, PE; Kwon, S; Lubeck, BA; Wilkinson, JE; Srinivasan, RS; Sevick-Muraca, E; King, PD,期刊：Journal of clinical investigation, 页码：733-747 , 文章类型： Article，,卷期：2012年122-2] RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regulator of blood vessel growth in adult mice and humans. In humans, RASA1 mutations cause capillary malformation-arteriovenous ma... The alpha v beta 6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells [作者：Sugimoto, K; Kudo, M; Sundaram, A; Ren, X; Huang, K; Bernstein, X; Wang, YL; Raymond, WW; Erie, DJ; Abrink, M; Caughey, GH; Huang, XZ; Sheppard, D,期刊：Journal of clinical investigation, 页码：748-758 , 文章类型： Article，,卷期：2012年122-2] Allergic asthma is the most common form of asthma, affecting more than 10 million Americans. Although it is clear that mast cells have a key role in the pathogenesis of allergic asthma, the mechanisms by which they regul... The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice [作者：Petruzziello-Pellegrini, TN; Yuen, DA; Page, AV; Patel, S; Soltyk, AM; Matouk, CC; Wong, DK; Turgeon, PJ; Fish, JE; Ho, JJD; Steer, BM; Khajoee, V; Tigdi, J; Lee, WL; Motto, DG; Advani, A; Gilbert, RE; Karumanchi, SA; Robinson, LA; Tarr, PI; Liles, WC; Brunton, JL; Marsden, PA,期刊：Journal of clinical investigation, 页码：759-776 , 文章类型： Article，,卷期：2012年122-2] Hemolytic uremic syndrome (HUS) is a potentially life-threatening condition. It often occurs after gastrointestinal infection with E. coil O157:H7, which produces Shiga toxins (Stx) that cause hemolytic anemia, thrombocy... Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents (vol 121, pg 3005, 2011) [作者：Lee, B; Clarke, D; Al Ahmad, A; Kahle, M; Parham, C; Auckland, L; Shaw, C; Fidanboylu, M; Orr, AW; Ogunshola, O; Fertala, A; Thomas, SA; Bix, GJ,期刊：Journal of clinical investigation, 页码：777-777 , 文章类型： Correction，,卷期：2012年122-2] Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy (vol 121, pg 3991, 2011) [作者：McCarthy, DD; Kujawa, J; Wilson, C; Papandile, A; Poreci, U; Porfilio, EA; Ward, L; Lawson, MAE; Macpherson, A; McCoy, KD; Pei, Y; Novak, L; Lee, JY; Julian, BA; Novak, J; Ranger, A; Gommerman, JL; Browning, JL,期刊：Journal of clinical investigation, 页码：778-778 , 文章类型： Correction，,卷期：2012年122-2] Obesity is associated with hypothalamic injury in rodents and humans (vol 122, pg 153, 2012) [作者：Thaler, JP; Yi, CX; Schur, EA; Guyenet, SJ; Hwang, BH; Dietrich, MO; Zhao, XL; Sarruf, DA; Izgur, V; Maravilla, KR; Nguyen, HT; Fischer, JD; Matsen, ME; Wisse, BE; Morton, GJ; Horvath, TL; Baskin, DG; Tschop, MH; Schwartz, MW,期刊：Journal of clinical investigation, 页码：778-778 , 文章类型： Correction，,卷期：2012年122-2] A fragment of secreted Hsp90 alpha carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice (vol 121, pg 4348, 2011) [作者：Cheng, CF; Sahu, D; Tsen, F; Zhao, ZW; Fan, JH; Kim, R; Wang, XY; O'Brien, K; Li, Y; Kuang, YT; Chen, M; Woodley, DT; Li, W,期刊：Journal of clinical investigation, 页码：779-779 , 文章类型： Correction，,卷期：2012年122-2]