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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Heparan sulfate sulfatase SULF2 regulates PDGFR alpha signaling and growth in human and mouse malignant glioma [作者：Phillips, JJ; Huillard, E; Robinson, AE; Ward, A; Lum, DH; Polley, MY; Rosen, SD; Rowitch, DH; Werb, Z,期刊：Journal of clinical investigation, 页码：911-922 , 文章类型： Article，,卷期：2012年122-3] Glioblastoma (GBM), a uniformly lethal brain cancer, is characterized by diffuse invasion and abnormal activation of multiple receptor tyrosine kinase (RTK) signaling pathways, presenting a major challenge to effective t... Essential role of gastric gland mucin in preventing gastric cancer in mice [作者：Karasawa, F; Shiota, A; Goso, Y; Kobayashi, M; Sato, Y; Masumoto, J; Fujiwara, M; Yokosawa, S; Muraki, T; Miyagawa, S; Ueda, M; Fukuda, MN; Fukuda, M; Ishihara, K; Nakayama, J,期刊：Journal of clinical investigation, 页码：923-934 , 文章类型： Article，,卷期：2012年122-3] Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc). Previously, we... The intersection of genetic and chemical genomic screens identifies GSK-3 alpha as a target in human acute myeloid leukemia [作者：Banerji, V; Frumm, SM; Ross, KN; Li, LS; Schinzel, AC; Hahn, CK; Kakoza, RM; Chow, KT; Ross, L; Alexe, G; Tolliday, N; Inguilizian, H; Galinsky, I; Stone, RM; DeAngelo, DJ; Roti, G; Aster, JC; Hahn, WC; Kung, AL; Stegmaier, K,期刊：Journal of clinical investigation, 页码：935-947 , 文章类型： Article，,卷期：2012年122-3] Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification and validation of new AM... Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome [作者：Malinge, S; Bliss-Moreau, M; Kirsammer, G; Diebold, L; Chlon, T; Gurbuxani, S; Crispino, JD,期刊：Journal of clinical investigation, 页码：948-962 , 文章类型： Article，,卷期：2012年122-3] Individuals with Down syndrome (DS; also known as trisomy 21) have a markedly increased risk of leukemia in childhood but a decreased risk of solid tumors in adulthood. Acquired mutations in the transcription factor-enco... Divergent requirement for G alpha s and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets [作者：Li, XL; Murray, F; Koide, N; Goldstone, J; Dann, SM; Chen, JZ; Bertin, S; Fu, G; Weinstein, LS; Chen, M; Corr, M; Eckmann, L; Insel, PA; Raz, E,期刊：Journal of clinical investigation, 页码：963-973 , 文章类型： Article，,卷期：2012年122-3] cAMP, the intracellular signaling molecule produced in response to GPCR signaling, has long been recognized as an immunosuppressive agent that inhibits T cell receptor activation and T cell function. However, recent stud... Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice [作者：Mei, JJ; Liu, YH; Dai, N; Hoffmann, C; Hudock, KM; Zhang, P; Guttentag, SH; Kolls, JK; Oliver, PM; Bushman, FD; Worthen, GS,期刊：Journal of clinical investigation, 页码：974-986 , 文章类型： Article，,卷期：2012年122-3] Neutrophils are essential for maintaining innate immune surveillance under normal conditions, but also represent a major contributor to tissue damage during inflammation. Neutrophil homeostasis is therefore tightly regul... Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice [作者：Nanjappa, SG; Heninger, E; Wuthrich, M; Sullivan, T; Klein, B,期刊：Journal of clinical investigation, 页码：987-999 , 文章类型： Article，,卷期：2012年122-3] Individuals who are immunocompromised, including AIDS patients with few CD4(+) T cells, are at increased risk for opportunistic fungal infections. The incidence of such infections is increasing worldwide, meaning that th... Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice [作者：Berglund, ED; Vianna, CR; Donato, J; Kim, MH; Chuang, JC; Lee, CE; Lauzon, DA; Lin, P; Brule, LJ; Scott, MM; Coppari, R; Elmquist, JK,期刊：Journal of clinical investigation, 页码：1000-1009 , 文章类型： Article，,卷期：2012年122-3] Leptin action on its receptor (LEPR) stimulates energy expenditure and reduces food intake, thereby lowering body weight. One leptin-sensitive target cell mediating these effects on energy balance is the proopiomelanocor... FOSL2 promotes leptin gene expression in human and mouse adipocytes [作者：Wrann, CD; Eguchi, J; Bozec, A; Xu, Z; Mikkelsen, T; Gimble, J; Nave, H; Wagner, EF; Ong, SE; Rosen, ED,期刊：Journal of clinical investigation, 页码：1010-1021 , 文章类型： Article，,卷期：2012年122-3] The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyt... Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes [作者：Bordicchia, M; Liu, DX; Amri, EZ; Ailhaud, G; Dessi-Fulgheri, P; Zhang, CY; Takahashi, N; Sarzani, R; Collins, S,期刊：Journal of clinical investigation, 页码：1022-1036 , 文章类型： Article，,卷期：2012年122-3] The ability of mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat depots. Activation of beta-adrenergic receptors (beta-ARs) can in... Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy [作者：Fewou, SN; Rupp, A; Nickolay, LE; Carrick, K; Greenshields, KN; Pediani, J; Plomp, JJ; Willison, HJ,期刊：Journal of clinical investigation, 页码：1037-1051 , 文章类型： Article，,卷期：2012年122-3] In the Guillain-Barre syndrome subform acute motor axonal neuropathy (AMAN), Campylobacter jejuni enteritis triggers the production of anti-ganglioside Abs (AGAbs), leading to immune-mediated injury of distal motor nerve... Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice [作者：Sakamori, R; Das, S; Yu, SY; Feng, SS; Stypulkowski, E; Guan, YZ; Douard, V; Tang, WX; Ferraris, RP; Harada, A; Brakebusch, C; Guo, W; Gao, N,期刊：Journal of clinical investigation, 页码：1052-1065 , 文章类型： Article，,卷期：2012年122-3] The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epit... Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer [作者：Kohrt, HE; Houot, R; Weiskopf, K; Goldstein, MJ; Scheeren, F; Czerwinski, D; Colevas, AD; Weng, WK; Clarke, MF; Carlson, RW; Stockdale, FE; Mollick, JA; Chen, LP; Levy, R,期刊：Journal of clinical investigation, 页码：1066-1075 , 文章类型： Article，,卷期：2012年122-3] Trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2; also known as HER-2/neu), is indicated for the treatment of women with either early stage or metastatic HER2(+) breast cancer. ... Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV [作者：Jones, T; Ye, FC; Bedolla, R; Huang, YF; Meng, J; Qian, LW; Pan, HY; Zhou, FC; Moody, R; Wagner, B; Arar, M; Gao, SJ,期刊：Journal of clinical investigation, 页码：1076-1081 , 文章类型： Article，,卷期：2012年122-3] Infections by viruses are associated with approximately 12% of human cancer. Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several malignancies commonly found in AIDS patients. The mechanism of KSH... DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection [作者：Oertli, M; Sundquist, M; Hitzler, I; Engler, DB; Arnold, IC; Reuter, S; Maxeiner, J; Hansson, M; Taube, C; Quiding-Jarbrink, M; Muller, A,期刊：Journal of clinical investigation, 页码：1082-1096 , 文章类型： Article，,卷期：2012年122-3] Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic ... A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration [作者：Ng, R; Song, GS; Roll, GR; Frandsen, NM; Willenbring, H,期刊：Journal of clinical investigation, 页码：1097-1108 , 文章类型： Article，,卷期：2012年122-3] MicroRNA-21 (miR-21) is thought to be an oncomir because it promotes cancer cell proliferation, migration, and survival. miR-21 is also expressed in normal cells, but its physiological role is poorly understood. Recently...