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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共49条记录   The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation [作者：McGill, MR; Sharpe, MR; Williams, CD; Taha, M; Curry, SC; Jaeschke, H,期刊：Journal of clinical investigation, 页码：1574-1583 , 文章类型： Article，,卷期：2012年122-4] Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a reactive metabolite that binds to proteins. In rodents, this leads to mitochondria' dysfunction a... Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes (vol 122, pg 1022, 2012) [作者：Bordicchia, M; Liu, DX; Amri, EZ; Ailhaud, G; Dessi-Fulgheri, P; Zhang, CY; Takahashi, N; Sarzani, R; Collins, S,期刊：Journal of clinical investigation, 页码：1584-1584 , 文章类型： Correction，,卷期：2012年122-4] Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice (vol 119, pg 1230, 2009) [作者：Ling, HY; Zhang, T; Pereira, L; Means, CK; Cheng, HQ; Gu, YS; Dalton, ND; Peterson, KL; Chen, J; Bers, D; Brown, JH,期刊：Journal of clinical investigation, 页码：1584-1584 , 文章类型： Correction，,卷期：2012年122-4] An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice (vol 118, pg 3870, 2008) [作者：Sheikh, F; Raskin, A; Chu, PH; Lange, S; Domenighetti, AA; Zheng, M; Liang, XQ; Zhang, T; Yajima, T; Gu, YS; Dalton, ND; Mahata, SK; Dorn, GW; Brown, JH; Peterson, KL; Omens, JH; McCulloch, AD; Chen, J,期刊：Journal of clinical investigation, 页码：1584-1584 , 文章类型： Correction，,卷期：2012年122-4] Great expectations [作者：Rockman, HA,期刊：Journal of clinical investigation, 页码：1133-1133 , 文章类型： Editorial Material，,卷期：2012年122-4] On the occasion of the 200th anniversary of Charles Dickens's birth, I am struck by his creative genius and by the parallel between the intellectual development of his protagonists and the evolution of peer review. Like ... A conversation with Harold Varmus [作者：Neill, US; Varmus, H,期刊：Journal of clinical investigation, 页码：1134-1135 , 文章类型： Editorial Material，,卷期：2012年122-4] William G. Kaelin Jr. and Gregg L. Semenza receive the 2012 ASCI/Stanley J. Korsmeyer Award [作者：Claiborn, K,期刊：Journal of clinical investigation, 页码：1136-1137 , 文章类型： News Item，,卷期：2012年122-4] Chromosomal instability and cancer: a complex relationship with therapeutic potential [作者：Bakhoum, SF; Compton, DA,期刊：Journal of clinical investigation, 页码：1138-1143 , 文章类型： Article，,卷期：2012年122-4] Chromosomal instability (CIN) is a hallmark of human neoplasms. Despite its widespread prevalence, knowledge of the mechanisms and contributions of CIN in cancer has been elusive. It is now evident that the role of CIN i... Lessons learned at the intersection of immunology and neuroscience [作者：Steinman, L,期刊：Journal of clinical investigation, 页码：1146-1148 , 文章类型： Review，,卷期：2012年122-4] Neurobiologists and immunologists study concepts often signified with identical terminology. Scientists in both fields study a structure known as the synapse, and each group analyzes a subject called memory. Is this a qu... Signaling at neuro/immune synapses [作者：Dustin, ML,期刊：Journal of clinical investigation, 页码：1149-1155 , 文章类型： Review，,卷期：2012年122-4] Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of ph... The immunology of neurodegeneration [作者：Czirr, E; Wyss-Coray, T,期刊：Journal of clinical investigation, 页码：1156-1163 , 文章类型： Review，,卷期：2012年122-4] While immune responses in neurodegeneration were regarded as little more than a curiosity a decade ago, they are now increasingly moving toward center stage. Factors driving this movement include the recognition that mos... Innate immunity in the central nervous system [作者：Ransohoff, RM; Brown, MA,期刊：Journal of clinical investigation, 页码：1164-1171 , 文章类型： Review，,卷期：2012年122-4] Immune responses in the CNS are common, despite its perception as a site of immune privilege. These responses can be mediated by resident microglia and astrocytes, which are innate immune cells without direct counterpart... The adaptive immune system in diseases of the central nervous system [作者：Wraith, DC; Nicholson, LB,期刊：Journal of clinical investigation, 页码：1172-1179 , 文章类型： Review，,卷期：2012年122-4] Tissues of the CNS, such as the brain, optic nerves, and spinal cord, may be affected by a range of insults including genetic, autoimmune, infectious, or neurodegenerative diseases and cancer. The immune system is involv... Multiple sclerosis [作者：Nylander, A; Hafler, DA,期刊：Journal of clinical investigation, 页码：1180-1188 , 文章类型： Review，,卷期：2012年122-4] Multiple sclerosis (MS) is a multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual. While the formation and persiste... Secretory products of macrophages: twenty-five years on [作者：Nathan, C,期刊：Journal of clinical investigation, 页码：1189-1190 , 文章类型： Article，,卷期：2012年122-4] No longer do scientists look down on macrophages as "garbage men" that act "nonspecifically." Last fall's Nobel Prizes honored two of the few scientists who studied macrophages three decades ago. Now perhaps thousands do... Alzheimer's disease: the new promise [作者：Strittmatter, WJ,期刊：Journal of clinical investigation, 页码：1191-1191 , 文章类型： Editorial Material，,卷期：2012年122-4] Clinical vignette: A 59-year-old aeronautical engineer is referred to you for evaluation because of increasing difficulty with job performance over the last several years. Difficulty managing home finances, getting lost ...