- Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice
[作者:Rotolo, J; Stancevic, B; Zhang, JJ; Hua, GQ; Fuller, J; Yin, XL; Haimovitz-Friedman, A; Kim, K; Qian, M; Cardo-Vila, M; Fuks, Z; Pasqualini, R; Arap, W; Kolesnick, R,期刊:Journal of clinical investigation, 页码:1786-1790 , 文章类型: Article,,卷期:2012年122-5]
- Radiation gastrointestinal (GI) syndrome is a major lethal toxicity that may occur after a radiation/nuclear incident. Currently, there are no prophylactic countermeasures against radiation GI syndrome lethality for firs...
- Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
[作者:Harre, U; Georgess, D; Bang, H; Bozec, A; Axmann, R; Ossipova, E; Jakobsson, PJ; Baum, W; Nimmerjahn, F; Szarka, E; Sarmay, G; Krumbholz, G; Neumann, E; Toes, R; Scherer, HU; Catrina, AI; Klareskog, L; Jurdic, P; Schett, G,期刊:Journal of clinical investigation, 页码:1791-1802 , 文章类型: Article,,卷期:2012年122-5]
- Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated proteins are among the strongest risk factors for bone destru...
- Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization
[作者:Lieben, L; Masuyama, R; Torrekens, S; Van Looveren, R; Schrooten, J; Baatsen, P; Lafage-Proust, MH; Dresselaers, T; Feng, JQ; Bonewald, LF; Meyer, MB; Pike, JW; Bouillon, R; Carmeliet, G,期刊:Journal of clinical investigation, 页码:1803-1815 , 文章类型: Article,,卷期:2012年122-5]
- Serum calcium levels are tightly controlled by an integrated hormone-controlled system that involves active vitamin D [1,25(OH)(2)D], which can elicit calcium mobilization from bone when intestinal calcium absorption is ...
- CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease
[作者:De Luca, A; Iannitti, RG; Bozza, S; Beau, R; Casagrande, A; D'Angelo, C; Moretti, S; Cunha, C; Giovannini, G; Massi-Benedetti, C; Carvalho, A; Boon, L; Latge, JP; Romani, L,期刊:Journal of clinical investigation, 页码:1816-1831 , 文章类型: Article,,卷期:2012年122-5]
- Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate ...
- ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion
[作者:Long, WW; Foulds, CE; Qin, J; Liu, J; Ding, C; Lonard, DM; Solis, LM; Wistuba, II; Qin, J; Tsai, SY; Tsai, MJ; O'Malley, BW,期刊:Journal of clinical investigation, 页码:1869-1880 , 文章类型: Article,,卷期:2012年122-5]
- In contrast to the well-studied classic MAPKs, such as ERK1/2, little is known concerning the regulation and substrates of the atypical MAPK ERK3 signaling cascade and its function in cancer progression. Here, we report ...
- Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and beta-catenin interactions
[作者:Lin, YY; Hsu, YH; Huang, HY; Shann, YJ; Huang, CYF; Wei, SC; Chen, CL; Jou, TS,期刊:Journal of clinical investigation, 页码:1881-1894 , 文章类型: Article,,卷期:2012年122-5]
- Dysregulation of canonical Wnt signaling is thought to play a role in colon carcinogenesis. beta-Catenin, a key mediator of the pathway, is stabilized upon Wnt activation and accumulates in the nucleus, where it can inte...
- SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
[作者:Wang, CA; Jedlicka, P; Patrick, AN; Micalizzi, DS; Lemmer, KC; Deitsch, E; Casas-Selves, M; Harrell, JC; Ford, HL,期刊:Journal of clinical investigation, 页码:1895-1906 , 文章类型: Article,,卷期:2012年122-5]
- An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells infiltrate the lymphatic system are not completely understood. Recen...
- Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis
[作者:Anderson, PD; McKissic, SA; Logan, M; Roh, M; Franco, OE; Wang, J; Doubinskaia, I; van der Meer, R; Hayward, SW; Eischen, CM; Eltoum, IE; Abdulkadir, SA,期刊:Journal of clinical investigation, 页码:1907-1919 , 文章类型: Article,,卷期:2012年122-5]
- Cooperativity between oncogenic mutations is recognized as a fundamental feature of malignant transformation, and it may be mediated by synergistic regulation of the expression of pro- and antitumorigenic target genes. H...
- Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer
[作者:Nacerddine, K; Beaudry, JB; Ginjala, V; Westerman, B; Mattiroli, F; Song, JY; van der Poel, H; Ponz, OB; Pritchard, C; Cornelissen-Steijger, P; Zevenhoven, J; Tanger, E; Sixma, TK; Ganesan, S; van Lohuizen, M,期刊:Journal of clinical investigation, 页码:1920-1932 , 文章类型: Article,,卷期:2012年122-5]
- Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic events and the upregulation of polycomb grou...
- Hepatocyte-specific mutation of both NF-kappa B RelA and STAT3 abrogates the acute phase response in mice
[作者:Quinton, LJ; Blahna, MT; Jones, MR; Allen, E; Ferrari, JD; Hilliard, KL; Zhang, XL; Sabharwal, V; Algul, H; Akira, S; Schmid, RM; Pelton, SI; Spira, A; Mizgerd, JP,期刊:Journal of clinical investigation, 页码:1758-1763 , 文章类型: Article,,卷期:2012年122-5]
- The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effec...
- Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model
[作者:Ying, WZ; Allen, CE; Curtis, LM; Aaron, KJ; Sanders, PW,期刊:Journal of clinical investigation, 页码:1777-1785 , 文章类型: Article,,卷期:2012年122-5]
- A common renal complication of multiple myeloma is "myeloma kidney," a condition also known as cast nephropathy. The renal lesions (casts) are directly related to the production of monoclonal immunoglobulin free light ch...
- The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
[作者:Zelenay, S; Keller, AM; Whitney, PG; Schraml, BU; Deddouche, S; Rogers, NC; Schulz, O; Sancho, D; Sousa, CRE,期刊:Journal of clinical investigation, 页码:1615-1627 , 文章类型: Article,,卷期:2012年122-5]
- DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell recognition to cross-priming. Here we found th...
- The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice
[作者:Iborra, S; Izquierdo, HM; Martinez-Lopez, M; Blanco-Menendez, N; Sousa, CRE; Sancho, D,期刊:Journal of clinical investigation, 页码:1628-1643 , 文章类型: Article,,卷期:2012年122-5]
- In order to prime T cells, DCs integrate signals emanating directly from pathogens and from their noxious action on the host. DNGR-1 (CLEC9A) is a DC-restricted receptor that detects dead cells. Therefore, we investigate...
- Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation
[作者:Bibollet-Ruche, F; Heigele, A; Keele, BF; Easlick, JL; Decker, JM; Takehisa, J; Learn, G; Sharp, PM; Hahn, BH; Kirchhoff, F,期刊:Journal of clinical investigation, 页码:1644-1652 , 文章类型: Article,,卷期:2012年122-5]
- SIVs infecting wild-living apes in west central Africa have crossed the species barrier to humans on at least four different occasions, one of which spawned the AIDS pandemic. Although the chimpanzee precursor of pandemi...
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