- Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment
[作者:Singh, RK; Liao, WJ; Tracey-White, D; Recchi, C; Tolmachova, T; Rankin, SM; Hume, AN; Seabra, MC,期刊:Journal of cell science, 页码:1652-1656 , 文章类型: Article,,卷期:2012年125-7]
- Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab...
- IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells
[作者:Sureshbabu, A; Okajima, H; Yamanaka, D; Tonner, E; Shastri, S; Maycock, J; Szymanowska, M; Shand, J; Takahashi, SI; Beattie, J; Allan, G; Flint, D,期刊:Journal of cell science, 页码:1693-1705 , 文章类型: Article,,卷期:2012年125-7]
- Maintenance of tissue boundaries is crucial for control of metastasis. We describe a new signalling pathway in which epithelial cell disruption can be minimised and thereby restricts epithelial-mesenchymal transgressions...
- Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development
[作者:Okano, J; Lichti, U; Mamiya, S; Aronova, M; Zhang, GF; Yuspa, SH; Hamada, H; Sakai, Y; Morasso, MI,期刊:Journal of cell science, 页码:1827-1836 , 文章类型: Article,,卷期:2012年125-7]
- The process by which the periderm transitions to stratified epidermis with the establishment of the skin barrier is unknown. Understanding the cellular and molecular processes involved is crucial for the treatment of hum...
- Involvement of actin polymerization in podosome dynamics
[作者:Luxenburg, C; Winograd-Katz, S; Addadi, L; Geiger, B,期刊:Journal of cell science, 页码:1666-1672 , 文章类型: Article,,卷期:2012年125-7]
- Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and invasive features. Using live-cell microscopy...
- SNAREs, HOPS and regulatory lipids control the dynamics of vacuolar actin during homotypic fusion in S. cerevisiae
[作者:Karunakaran, S; Sasser, T; Rajalekshmi, S; Fratti, RA,期刊:Journal of cell science, 页码:1683-1692 , 文章类型: Article,,卷期:2012年125-7]
- Homotypic vacuole fusion requires SNAREs, the Rab Ypt7p, the tethering complex HOPS, regulatory lipids and actin. In Saccharomyces cerevisiae, actin functions at two stages of vacuole fusion. Pre-existing actin filaments...
- An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane
[作者:Galindo, A; Calcagno-Pizarelli, AM; Arst, HN; Penalva, MA,期刊:Journal of cell science, 页码:1784-1795 , 文章类型: Article,,卷期:2012年125-7]
- The fungal pal/RIM signalling pathway, which regulates gene expression in response to environmental pH involves, in addition to dedicated proteins, several components of ESCRT complexes, which suggested that pH signallin...
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