- Inhibition of Phosphorylation of Na+,K+-ATPase by Mutations Causing Familial Hemiplegic Migraine
[作者:Schack, VR; Holm, R; Vilsen, B,期刊:Journal of Biological Chemistry, 页码:2191-2202 , 文章类型: Article,,卷期:2012年287-3]
- The neurological disorder familial hemiplegic migraine type II (FHM2) is caused by mutations in the alpha 2-isoform of the Na+, K+-ATPase. We have studied the partial reaction steps of the Na+, K+-pump cycle in nine FHM2...
- Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches
[作者:Kefalov, VJ,期刊:Journal of Biological Chemistry, 页码:1635-1641 , 文章类型: Review,,卷期:2012年287-3]
- Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-ci...
- Beltless Translocation Domain of Botulinum Neurotoxin A Embodies a Minimum Ion-conductive Channel
[作者:Fischer, A; Sambashivan, S; Brunger, AT; Montal, M,期刊:Journal of Biological Chemistry, 页码:1657-1661 , 文章类型: Article,,卷期:2012年287-3]
- Botulinum neurotoxin, the causative agent of the paralytic disease botulism, is an endopeptidase composed of a catalytic domain (or light chain (LC)) and a heavy chain (HC) encompassing the translocation domain (TD) and ...
- Replication Factor C Is a More Effective Proliferating Cell Nuclear Antigen (PCNA) Opener than the Checkpoint Clamp Loader, Rad24-RFC
[作者:Thompson, JA; Marzahn, MR; O'Donnell, M; Bloom, LB,期刊:Journal of Biological Chemistry, 页码:2203-2209 , 文章类型: Article,,卷期:2012年287-3]
- Clamp loaders from all domains of life load clamps onto DNA. The clamp tethers DNA polymerases to DNA to increase the processivity of synthesis as well as the efficiency of replication. Here, we investigated proliferatin...
- Yeast Lipin 1 Orthologue Pah1p Regulates Vacuole Homeostasis and Membrane Fusion
[作者:Sasser, T; Qiu, QS; Karunakaran, S; Padolina, M; Reyes, A; Flood, B; Smith, S; Gonzales, C; Fratti, RA,期刊:Journal of Biological Chemistry, 页码:2221-2236 , 文章类型: Article,,卷期:2012年287-3]
- Vacuole homotypic fusion requires a group of regulatory lipids that includes diacylglycerol, a fusogenic lipid that is produced through multiple metabolic pathways including the dephosphorylation of phosphatidic acid (PA...
- Hypothalamic Ahi1 Mediates Feeding Behavior through Interaction with 5-HT2C Receptor
[作者:Wang, H; Huang, ZB; Huang, LS; Niu, SN; Rao, XR; Xu, J; Kong, H; Yang, JZ; Yang, C; Wu, DH; Li, SH; Li, XJ; Liu, TH; Sheng, GQ,期刊:Journal of Biological Chemistry, 页码:2237-2246 , 文章类型: Article,,卷期:2012年287-3]
- It is indicated that there are important molecules interacting with brain nervous systems to regulate feeding and energy balance by influencing the signaling pathways of these systems, but relatively few of the critical ...
- Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plenty of SH3s) Protein
[作者:Wilhelm, M; Kukekov, NV; Schmit, TL; Biagas, KV; Sproul, AA; Gire, S; Maes, ME; Xu, ZH; Greene, LA,期刊:Journal of Biological Chemistry, 页码:2247-2256 , 文章类型: Article,,卷期:2012年287-3]
- We report that Sh3rf2, a homologue of the pro-apoptotic scaffold POSH (Plenty of SH3s), acts as an anti-apoptotic regulator for the c-Jun N-terminal kinase (JNK) pathway. siRNA-mediated knockdown of Sh3rf2 promotes apopt...
- Cdc14 Phosphatases Preferentially Dephosphorylate a Subset of Cyclin-dependent kinase (Cdk) Sites Containing Phosphoserine
[作者:Bremmer, SC; Hall, H; Martinez, JS; Eissler, CL; Hinrichsen, TH; Rossie, S; Parker, LL; Hall, MC; Charbonneau, H,期刊:Journal of Biological Chemistry, 页码:1662-1669 , 文章类型: Article,,卷期:2012年287-3]
- Mitotic cell division is controlled by cyclin-dependent kinases (Cdks), which phosphorylate hundreds of protein substrates responsible for executing the division program. Cdk inactivation and reversal of Cdk-catalyzed ph...
- Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in Osteoblasts
[作者:Tang, WJ; Yang, F; Li, Y; de Crombrugghe, B; Jiao, HL; Xiao, GZ; Zhang, C,期刊:Journal of Biological Chemistry, 页码:1671-1678 , 文章类型: Article,,卷期:2012年287-3]
- Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation. The critical step in bone formation is to replace the avascular cartilage template with vascularize...
- Role of Junctin Protein Interactions in Cellular Dynamics of Calsequestrin Polymer upon Calcium Perturbation
[作者:Lee, KW; Maeng, JS; Choi, JY; Lee, YR; Hwang, CY; Park, SS; Park, HK; Chung, BH; Lee, SG; Kim, YS; Jeon, H; Eom, SH; Kang, C; Kim, DH; Kwon, KS,期刊:Journal of Biological Chemistry, 页码:1679-1687 , 文章类型: Article,,卷期:2012年287-3]
- Calsequestrin (CSQ), the major intrasarcoplasmic reticulum calcium storage protein, undergoes dynamic polymerization and depolymerization in a Ca(2+)-dependent manner. However, no direct evidence of CSQ depolymerization ...
- SATB Homeobox Proteins Regulate Trophoblast Stem Cell Renewal and Differentiation
[作者:Asanoma, K; Kubota, K; Chakraborty, D; Renaud, SJ; Wake, N; Fukushima, K; Soares, MJ; Rumi, MAK,期刊:Journal of Biological Chemistry, 页码:2257-2268 , 文章类型: Article,,卷期:2012年287-3]
- The morphogenesis of the hemochorial placenta is dependent upon the precise expansion and differentiation of trophoblast stem (TS) cells. SATB homeobox 1 (SATB1) and SATB2 are related proteins that have been implicated a...
- Five histidine kinases perceive osmotic stress and regulate distinct sets of genes in Synechocystis (vol 279, pg 53086, 2004)
[作者:Paithoonrangsarid, K; Shumskaya, MA; Kanesaki, Y; Satoh, S; Tabata, S; Los, DA; Zinchenko, VV; Hayashi, H; Tanticharoen, M; Suzuki, I; Murata, N,期刊:Journal of Biological Chemistry, 页码:2269-2269 , 文章类型: Correction,,卷期:2012年287-3]
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