- Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions
[作者:Shao, BH; Pennathur, S; Heinecke, JW,期刊:Journal of Biological Chemistry, 页码:6375-6386 , 文章类型: Article,,卷期:2012年287-9]
- Oxidative damage by myeloperoxidase (MPO) has been proposed to deprive HDL of its cardioprotective effects. In vitro studies reveal that MPO chlorinates and nitrates specific tyrosine residues of apoA-I, the major HDL pr...
- Molecular Determinants of Enterovirus 71 Viral Entry CLEFT AROUND GLN-172 ON VP1 PROTEIN INTERACTS WITH VARIABLE REGION ON SCAVENGE RECEPTOR B 2
[作者:Chen, P; Song, ZL; Qi, YH; Feng, XF; Xu, NQ; Sun, YY; Wu, X; Yao, X; Mao, QY; Li, XL; Dong, WJ; Wan, XB; Huang, N; Shen, XL; Liang, ZL; Li, WH,期刊:Journal of Biological Chemistry, 页码:6406-6420 , 文章类型: Article,,卷期:2012年287-9]
- Enterovirus 71 (EV71) is one of the major pathogens that cause hand, foot, and mouth disease outbreaks in young children in the Asia-Pacific region in recent years. Human scavenger receptor class B 2 (SCARB2) is the main...
- Regulation of Adipocyte Formation by GLP-1/GLP-1R Signaling
[作者:Challa, TD; Beaton, N; Arnold, M; Rudofsky, G; Langhans, W; Wolfrum, C,期刊:Journal of Biological Chemistry, 页码:6421-6430 , 文章类型: Article,,卷期:2012年287-9]
- Increased nutrient intake leads to excessive adipose tissue accumulation, obesity, and the development of associated metabolic disorders. How the intestine signals to adipose tissue to adapt to increased nutrient intake,...
- Dwarfism in Mice Lacking Collagen-binding Integrins alpha 2 beta 1 and alpha 11 beta 1 Is Caused by Severely Diminished IGF-1 Levels
[作者:Blumbach, K; Niehoff, A; Belgardt, BF; Ehlen, HWA; Schmitz, M; Hallinger, R; Schulz, JN; Bruning, JC; Krieg, T; Schubert, M; Gullberg, D; Eckes, B,期刊:Journal of Biological Chemistry, 页码:6431-6440 , 文章类型: Article,,卷期:2012年287-9]
- Mice with a combined deficiency in the alpha 2 beta 1 and alpha 11 beta 1 integrins lack the major receptors for collagen I. These mutants are born with inconspicuous differences in size but develop dwarfism within the f...
- Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E-2 Production in Astrocytes
[作者:Font-Nieves, M; Sans-Fons, MG; Gorina, R; Bonfill-Teixidor, E; Salas-Perdomo, A; Marquez-Kisinousky, L; Santalucia, T; Planas, AM,期刊:Journal of Biological Chemistry, 页码:6454-6468 , 文章类型: Article,,卷期:2012年287-9]
- Pathological conditions and pro-inflammatory stimuli in the brain induce cyclooxygenase-2 (COX-2), a key enzyme in arachidonic acid metabolism mediating the production of prostanoids that, among other actions, have stron...
- Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication Stress
[作者:Guler, GD; Liu, HJ; Vaithiyalingam, S; Arnett, DR; Kremmer, E; Chazin, WJ; Fanning, E,期刊:Journal of Biological Chemistry, 页码:6469-6481 , 文章类型: Article,,卷期:2012年287-9]
- Maintenance of genomic stability in proliferating cells depends on a network of proteins that coordinate chromosomal replication with DNA damage responses. Human DNA helicase B (HELB or HDHB) has been implicated in chrom...
- Angiogenesis Induced by Signal Transducer and Activator of Transcription 5A (STAT5A) Is Dependent on Autocrine Activity of Proliferin
[作者:Yang, XH; Qiao, DH; Meyer, K; Pier, T; Keles, S; Friedl, A,期刊:Journal of Biological Chemistry, 页码:6490-6502 , 文章类型: Article,,卷期:2012年287-9]
- Multiple secreted factors induce the formation of new blood vessels (angiogenesis). The signal transduction events that orchestrate the numerous cellular activities required for angiogenesis remain incompletely understoo...
- Cytosolic Carboxypeptidase 1 Is Involved in Processing alpha- and beta-Tubulin
[作者:Berezniuk, I; Vu, HT; Lyons, PJ; Sironi, JJ; Xiao, H; Burd, B; Setou, M; Angeletti, RH; Ikegami, K; Fricker, LD,期刊:Journal of Biological Chemistry, 页码:6503-6517 , 文章类型: Article,,卷期:2012年287-9]
- The Purkinje cell degeneration (pcd) mouse has a disruption in the gene encoding cytosolic carboxypeptidase 1 (CCP1). This study tested two proposed functions of CCP1: degradation of intracellular peptides and processing...
- Formation of New High Density Glycogen-Microtubule Structures Is Induced by Cardiac Steroids
[作者:Fridman, E; Lichtstein, D; Rosen, H,期刊:Journal of Biological Chemistry, 页码:6518-6529 , 文章类型: Article,,卷期:2012年287-9]
- Cardiac steroids (CS), an important class of naturally occurring compounds, are synthesized in plants and animals. The only established receptor for CS is the ubiquitous Na+, K+-ATPase, a major plasma membrane transporte...
- An Unusual Subtilisin-like Serine Protease Is Essential for Biogenesis of Quinohemoprotein Amine Dehydrogenase
[作者:Nakai, T; Ono, K; Kuroda, S; Tanizawa, K; Okajima, T,期刊:Journal of Biological Chemistry, 页码:6530-6538 , 文章类型: Article,,卷期:2012年287-9]
- Quinohemoprotein amine dehydrogenase (QHNDH), an alpha beta gamma heterotrimer present in the periplasm of several Gram-negative bacteria, catalyzes the oxidative deamination of various aliphatic amines such as n-butylam...
- Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
[作者:Camp, ND; James, RG; Dawson, DW; Yan, F; Davison, JM; Houck, SA; Tang, XB; Zheng, N; Major, MB; Moon, RT,期刊:Journal of Biological Chemistry, 页码:6539-6550 , 文章类型: Article,,卷期:2012年287-9]
- WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms tumor. Among its known functions, WTX interacts with the beta-transducin repeat containing family of ubiquitin ligase adaptors and ...
- Receptor for Activated C Kinase 1 (RACK1) Inhibits Function of Transient Receptor Potential (TRP)-type Channel Pkd2L1 through Physical Interaction
[作者:Yang, J; Wang, Q; Zheng, W; Tuli, J; Li, Q; Wu, Y; Hussein, S; Dai, XQ; Shafiei, S; Li, XG; Shen, PY; Tu, JC; Chen, XZ,期刊:Journal of Biological Chemistry, 页码:6551-6561 , 文章类型: Article,,卷期:2012年287-9]
- Pkd2L1 (also called TRPP3) is a non-selective cation channel permeable to Ca2+, Na+, and K+ and is activated by Ca2+. It is also part of an acid-triggered off-response cation channel complex. We previously reported roles...
- T7 RNA Polymerases Backed up by Covalently Trapped Proteins Catalyze Highly Error Prone Transcription
[作者:Nakano, T; Ouchi, R; Kawazoe, J; Pack, SP; Makino, K; Ide, H,期刊:Journal of Biological Chemistry, 页码:6562-6572 , 文章类型: Article,,卷期:2012年287-9]
- RNA polymerases (RNAPs) transcribe genes through the barrier of nucleoproteins and site-specific DNA-binding proteins on their own or with the aid of accessory factors. Proteins are often covalently trapped on DNA by DNA...
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