个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共80条记录   Regulation of Transcription Factor Twist Expression by the DNA Architectural Protein High Mobility Group A2 during Epithelial-to-Mesenchymal Transition [作者：Tan, EJ; Thuault, S; Caja, L; Carletti, T; Heldin, CH; Moustakas, A,期刊：Journal of Biological Chemistry, 页码：7134-7145 , 文章类型： Article，,卷期：2012年287-10] Deciphering molecular mechanisms that control epithelial-to-mesenchymal transition (EMT) contributes to our understanding of how tumor cells become invasive and competent for intravasation. We have established that trans... Amyloid-beta Oligomers Induce Differential Gene Expression in Adult Human Brain Slices [作者：Sebollela, A; Freitas-Correa, L; Oliveira, FF; Paula-Lima, AC; Saraiva, LM; Martins, SM; Mota, LD; Torres, C; Alves-Leon, S; de Souza, JM; Carraro, DM; Brentani, H; De Felice, FG; Ferreira, ST,期刊：Journal of Biological Chemistry, 页码：7436-7445 , 文章类型： Article，,卷期：2012年287-10] Cognitive decline in Alzheimer disease (AD) is increasingly attributed to the neuronal impact of soluble oligomers of the amyloid-beta peptide (A beta Os). Current knowledge on the molecular and cellular mechanisms under... Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF [作者：Kerschbaumer, RJ; Rieger, M; Volkel, D; Le Roy, D; Roger, T; Garbaraviciene, J; Boehncke, WH; Mullberg, J; Hoet, RM; Wood, CR; Antoine, G; Thiele, M; Savidis-Dacho, H; Dockal, M; Ehrlich, H; Calandra, T; Scheiflinger, F,期刊：Journal of Biological Chemistry, 页码：7446-7455 , 文章类型： Article，,卷期：2012年287-10] The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully human anti-MIF antibodies was g... Structural Model of Channelrhodopsin [作者：Watanabe, HC; Welke, K; Schneider, F; Tsunoda, S; Zhang, F; Deisseroth, K; Hegemann, P; Elstner, M,期刊：Journal of Biological Chemistry, 页码：7456-7466 , 文章类型： Article，,卷期：2012年287-10] Channelrhodopsins (ChRs) are light-gated cation channels that mediate ion transport across membranes in microalgae (vectorial catalysis). ChRs are now widely used for the analysis of neural networks in tissues and living... Molecular Dynamics Simulations of Creatine Kinase and Adenine Nucleotide Translocase in Mitochondrial Membrane Patch [作者：Karo, J; Peterson, P; Vendelin, M,期刊：Journal of Biological Chemistry, 页码：7467-7476 , 文章类型： Article，,卷期：2012年287-10] Interaction between mitochondrial creatine kinase (MtCK) and adenine nucleotide translocase (ANT) can play an important role in determining energy transfer pathways in the cell. Although the functional coupling between M... Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63 [作者：Chen, C; Gorlatova, N; Herzberg, O,期刊：Journal of Biological Chemistry, 页码：7477-7486 , 文章类型： Article，,卷期：2012年287-10] We show that changes in the nucleotide sequence alter the DNA conformation in the crystal structures of p63 DNA-binding domain (p63DBD) bound to its response element. The conformation of a 22-bp canonical response elemen... Functional Characterization of a Novel Aquaporin from Dictyostelium discoideum Amoebae Implies a Unique Gating Mechanism [作者：von Bulow, J; Muller-Lucks, A; Kai, L; Bernhard, F; Beitz, E,期刊：Journal of Biological Chemistry, 页码：7487-7494 , 文章类型： Article，,卷期：2012年287-10] The social amoeba Dictyostelium discoideum is a widely used model organism for studying basic functions of protozoan and metazoan cells, such as osmoregulation and cell motility. There is evidence from other species that... The C-terminal Proteolytic Fragment of the Breast Cancer Susceptibility Type 1 Protein (BRCA1) Is Degraded by the N-end Rule Pathway [作者：Xu, ZZ; Payoe, R; Fahlman, RP,期刊：Journal of Biological Chemistry, 页码：7495-7502 , 文章类型： Article，,卷期：2012年287-10] The breast cancer susceptibility type 1 gene product (BRCA1) is cleaved by caspases upon the activation of apoptotic pathways. After proteolysis the C-terminal fragment has been reported to translocate to the cytoplasm a... miR-30 Family Members Negatively Regulate Osteoblast Differentiation [作者：Wu, TT; Zhou, HB; Hong, YF; Li, J; Jiang, XQ; Huang, H,期刊：Journal of Biological Chemistry, 页码：7503-7511 , 文章类型： Article，,卷期：2012年287-10] miRNAs are endogenously expressed 18- to 25-nucleotide RNAs that regulate gene expression through translational repression by binding to a target mRNA. Recently, it has been indicated that miRNAs are closely related to o... Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region [作者：Budini, M; Buratti, E; Stuani, C; Guarnaccia, C; Romano, V; De Conti, L; Baralle, FE,期刊：Journal of Biological Chemistry, 页码：7512-7525 , 文章类型： Article，,卷期：2012年287-10] TDP-43 is one of the major components of the neuronal and glial inclusions observed in several neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. These characteristic ... Latency-associated Peptide of Transforming Growth Factor-beta 1 Is Not Subject to Physiological Mannose Phosphorylation [作者：Barnes, J; Warejcka, D; Simpliciano, J; Twining, S; Steet, R,期刊：Journal of Biological Chemistry, 页码：7526-7534 , 文章类型： Article，,卷期：2012年287-10] Latent TGF-beta 1 was one of the first non-lysosomal glycoproteins reported to bear mannose 6-phosphate (Man-6-P) residues on its N-glycans. Prior studies have suggested that this sugar modification regulates the activat... Incompatibility between a Pair of Residues from the Pre-M1 Linker and Cys-loop Blocks Surface Expression of the Glycine Receptor [作者：Shan, Q; Lynch, JW,期刊：Journal of Biological Chemistry, 页码：7535-7542 , 文章类型： Article，,卷期：2012年287-10] Regulation of cell membrane excitability can be achieved either by modulating the functional properties of cell membrane-expressed single channels or by varying the number of expressed channels. Whereas the structural ba... Mutation of Glu(521) or Glu(535) in Cytoplasmic Loop 5 Causes Differential Misfolding in Multiple Domains of Multidrug and Organic Anion Transporter MRP1 (ABCC1) [作者：Iram, SH; Cole, SPC,期刊：Journal of Biological Chemistry, 页码：7543-7555 , 文章类型： Article，,卷期：2012年287-10] The polytopic 5-domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a variety of drugs and organic anions across the plasma membrane. Four charged residues in the fifth cytoplasmic loop (CL5) connecting transmemb... Epithelial Protein Lost In Neoplasm (EPLIN) Interacts with alpha-Catenin and Actin Filaments in Endothelial Cells and Stabilizes Vascular Capillary Network in Vitro [作者：Chervin-Petinot, A; Courcon, M; Almagro, S; Nicolas, A; Grichine, A; Grunwald, D; Prandini, MH; Huber, P; Gulino-Debrac, D,期刊：Journal of Biological Chemistry, 页码：7556-7572 , 文章类型： Article，,卷期：2012年287-10] Adherens junctions are required for vascular endothelium integrity. These structures are formed by the clustering of the homophilic adhesive protein VE-cadherin, which recruits intracellular partners, such as beta- and a... Identification of Novel Interaction between Annexin A2 and Keratin 17 EVIDENCE FOR RECIPROCAL REGULATION [作者：Chung, BM; Murray, CI; Van Eyk, JE; Coulombe, PA,期刊：Journal of Biological Chemistry, 页码：7573-7581 , 文章类型： Article，,卷期：2012年287-10] Keratins are cytoplasmic intermediate filament proteins providing crucial structural support in epithelial cells. Keratin expression has diagnostic and even prognostic value in disease settings, and recent studies have u... Characterizing Phospholamban to Sarco(endo) plasmic Reticulum Ca2+-ATPase 2a (SERCA2a) Protein Binding Interactions in Human Cardiac Sarcoplasmic Reticulum Vesicles Using Chemical Cross-linking [作者：Akin, BL; Jones, LR,期刊：Journal of Biological Chemistry, 页码：7582-7593 , 文章类型： Article，,卷期：2012年287-10] Chemical cross-linking was used to study protein binding interactions between native phospholamban (PLB) and SERCA2a in sarcoplasmic reticulum (SR) vesicles prepared from normal and failed human hearts. Lys(27) of PLB wa...