- Allele-specific Differences in Activity of a Novel Cannabinoid Receptor 1 (CNR1) Gene Intronic Enhancer in Hypothalamus, Dorsal Root Ganglia, and Hippocampus
[作者:Nicoll, G; Davidson, S; Shanley, L; Hing, B; Lear, M; McGuffin, P; Ross, R; MacKenzie, A,期刊:Journal of Biological Chemistry, 页码:12828-12834 , 文章类型: Article,,卷期:2012年287-16]
- Polymorphisms within intron 2 of the CNR1 gene, which encodes cannabinoid receptor 1 (CB1), have been associated with addiction, obesity, and brain volume deficits. We used comparative genomics to identify a polymorphic ...
- Growth and Translation Inhibition through Sequence-specific RNA Binding by Mycobacterium tuberculosis VapC Toxin
[作者:Sharp, JD; Cruz, JW; Raman, S; Inouye, M; Husson, RN; Woychik, NA,期刊:Journal of Biological Chemistry, 页码:12835-12847 , 文章类型: Article,,卷期:2012年287-16]
- The Mycobacterium tuberculosis genome harbors an unusually large number of toxin-antitoxin (TA) modules. Curiously, over half of these are VapBC (virulence-associated protein) family members. Nonetheless, the cellular ta...
- Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
[作者:Murai, J; Huang, SYN; Das, BB; Dexheimer, TS; Takeda, S; Pommier, Y,期刊:Journal of Biological Chemistry, 页码:12848-12857 , 文章类型: Article,,卷期:2012年287-16]
- Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes (Top1cc) by hydrolyzing their 3'-phosphotyrosyl DNA bonds and repairs bleomycin-induced DNA damage by hydrolyzing 3'-phosphoglycolates. Ye...
- Mapping Precursor-binding Site on TatC Subunit of Twin Arginine-specific Protein Translocase by Site-specific Photo Cross-linking
[作者:Zoufaly, S; Frobel, J; Rose, P; Flecken, T; Maurer, C; Moser, M; Muller, M,期刊:Journal of Biological Chemistry, 页码:13430-13441 , 文章类型: Article,,卷期:2012年287-16]
- A number of secreted precursor proteins of bacteria, archaea, and plant chloroplasts stand out by a conserved twin arginine-containing sequence motif in their signal peptides. Many of these precursor proteins are secrete...
- Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na+/H+ Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process
[作者:Zizak, M; Chen, T; Bartonicek, D; Sarker, R; Zachos, NC; Cha, BY; Kovbasnjuk, O; Korac, J; Mohan, S; Cole, R; Chen, YP; Tse, CM; Donowitz, M,期刊:Journal of Biological Chemistry, 页码:13442-13456 , 文章类型: Article,,卷期:2012年287-16]
- The epithelial brush border (BB) Na+/H+ exchanger 3 (NHE3) accounts for most renal and intestinal Na+ absorption. Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibits NHE3 activity under basal conditions in inta...
- Sphingosine 1-Phosphate (S1P) Regulates Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells
[作者:Stanford, JC; Morris, AJ; Sunkara, M; Popa, GJ; Larson, KL; Ozcan, S,期刊:Journal of Biological Chemistry, 页码:13457-13464 , 文章类型: Article,,卷期:2012年287-16]
- Recent studies suggest that sphingolipid metabolism is altered during type 2 diabetes. Increased levels of the sphingolipid ceramide are associated with insulin resistance. However, a role for sphingolipids in pancreatic...
- Human Anti-prion Antibodies Block Prion Peptide Fibril Formation and Neurotoxicity
[作者:Wei, X; Roettger, Y; Tan, BL; He, YZ; Dodel, R; Hampel, H; Wei, G; Haney, J; Gu, HY; Johnstone, BH; Liu, JY; Farlow, MR; Du, YS,期刊:Journal of Biological Chemistry, 页码:12858-12866 , 文章类型: Article,,卷期:2012年287-16]
- Prion diseases are a group of rare, fatal neurodegenerative disorders associated with a conformational transformation of the cellular prion protein (PrPC) into a self-replicating and proteinase K-resistant conformer, ter...
- Transcriptional Induction of Salt-inducible Kinase 1 by Transforming Growth Factor beta Leads to Negative Regulation of Type I Receptor Signaling in Cooperation with the Smurf2 Ubiquitin Ligase
[作者:Lonn, P; Vanlandewijck, M; Raja, E; Kowanetz, M; Watanabe, Y; Kowanetz, K; Vasilaki, E; Heldin, CH; Moustakas, A,期刊:Journal of Biological Chemistry, 页码:12867-12878 , 文章类型: Article,,卷期:2012年287-16]
- Transforming growth factor beta (TGF beta) regulates many physiological processes and requires control mechanisms to safeguard proper and timely action. We have previously described how negative regulation of TGF beta si...
- Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite
[作者:Katschke, KJ; Wu, P; Ganesan, R; Kelley, RF; Mathieu, MA; Hass, PE; Murray, J; Kirchhofer, D; Wiesmann, C; Campagne, MV,期刊:Journal of Biological Chemistry, 页码:12886-12892 , 文章类型: Article,,卷期:2012年287-16]
- By virtue of its amplifying property, the alternative complement pathway has been implicated in a number of inflammatory diseases and constitutes an attractive therapeutic target. An anti-factor D Fab fragment (AFD) was ...
- CYP52X1, Representing New Cytochrome P450 Subfamily, Displays Fatty Acid Hydroxylase Activity and Contributes to Virulence and Growth on Insect Cuticular Substrates in Entomopathogenic Fungus Beauveria bassiana
[作者:Zhang, SZ; Widemann, E; Bernard, G; Lesot, A; Pinot, F; Pedrini, N; Keyhani, NO,期刊:Journal of Biological Chemistry, 页码:13477-13486 , 文章类型: Article,,卷期:2012年287-16]
- Infection of insects by the entomopathogenic fungus Beauveria bassiana proceeds via attachment and penetration of the host cuticle. The outermost epicuticular layer or waxy layer of the insect represents a structure rich...
- Native Mutant Huntingtin in Human Brain EVIDENCE FOR PREVALENCE OF FULL-LENGTH MONOMER
[作者:Sapp, E; Valencia, A; Li, XY; Aronin, N; Kegel, KB; Vonsattel, JP; Young, AB; Wexler, N; DiFiglia, M,期刊:Journal of Biological Chemistry, 页码:13487-13499 , 文章类型: Article,,卷期:2012年287-16]
- Huntington disease (HD) is caused by polyglutamine expansion in theNterminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-lengthandfragmented. Hereweuse...
- Aminoglycoside 2 ''-Phosphotransferase IIIa (APH(2 '')-IIIa) Prefers GTP over ATP STRUCTURAL TEMPLATES FOR NUCLEOTIDE RECOGNITION IN THE BACTERIAL AMINOGLYCOSIDE-2 '' KINASES
[作者:Smith, CA; Toth, M; Frase, H; Byrnes, LJ; Vakulenko, SB,期刊:Journal of Biological Chemistry, 页码:12893-12903 , 文章类型: Article,,卷期:2012年287-16]
- Contrary to the accepted dogma that ATP is the canonical phosphate donor in aminoglycoside kinases and protein kinases, it was recently demonstrated that all members of the bacterial aminoglycoside 2 ''-phosphotransferas...
- O-GlcNAc Transferase Is Involved in Glucocorticoid Receptor-mediated Transrepression
[作者:Li, MD; Ruan, HB; Singh, JP; Zhao, L; Zhao, TT; Azarhoush, S; Wu, J; Evans, RM; Yang, XY,期刊:Journal of Biological Chemistry, 页码:12904-12912 , 文章类型: Article,,卷期:2012年287-16]
- Recruitment of O-GlcNAc transferase (OGT) to promoters plays an important role in gene repression. Glucocorticoid signaling represses the transcriptional activities of NF-kappa B and AP-1 through direct binding, yet the ...
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