- Distinct beta-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
[作者：Kanat, M; Mari, A; Norton, L; Whinier, D; DeFronzo, RA; Jenkinson, C; Abdul-Ghani, MA,期刊：Diabetes, 页码：447-453 , 文章类型： Article，,卷期：2012年61-2]
- To characterize the defects in beta-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, beta-cell glucose...
- TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice
[作者：Menghini, R; Casagrande, V; Menini, S; Marino, A; Marzano, V; Hribal, ML; Gentileschi, P; Lauro, D; Schillaci, O; Pugliese, G; Sbraccia, P; Urbani, A; Lauro, R; Federici, M,期刊：Diabetes, 页码：454-462 , 文章类型： Article，,卷期：2012年61-2]
- The tissue inhibitor of metalloproteinase (TIMP)3, a stromal protein that restrains the activity of proteases and receptors, is reduced in inflammatory metabolic disorders such as type 2 diabetes mellitus (T2DM) and athe...
- Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE(-/-)/LDL Receptor(-/-) Mice
[作者：Wang, ZH; Shang, YY; Zhang, S; Zhong, M; Wang, XP; Deng, JT; Pan, J; Zhang, Y; Zhang, W,期刊：Diabetes, 页码：463-473 , 文章类型： Article，,卷期：2012年61-2]
- Insulin resistance triggers the developments of diabetes mellitus and atherosclerosis. Tribbles homolog 3 (TRIB3) is involved in insulin resistance. We aimed to investigate whether TRIB3 is implicated in diabetic atheros...
- Bcl-2-Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice
[作者：Lau, GJ; Godin, N; Maachi, H; Lo, CS; Wu, SJ; Zhu, JX; Brezniceanu, ML; Chenier, I; Fragasso-Marquis, J; Lattouf, JB; Ethier, J; Filep, JG; Ingelfinger, JR; Nair, V; Kretzler, M; Cohen, CD; Zhang, SL; Chan, JSD,期刊：Diabetes, 页码：474-484 , 文章类型： Article，,卷期：2012年61-2]
- This study investigated the mechanisms underlying tubular apoptosis in diabetes by identifying proapoptotic genes that are differentially upregulated by reactive oxygen species in renal proximal tubular cells (RFTCs) in ...
- Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes
[作者：Zhong, YM; Li, JM; Chen, YM; Wang, JJ; Ratan, R; Zhang, SX,期刊：Diabetes, 页码：492-504 , 文章类型： Article，,卷期：2012年61-2]
- Inflammation plays an important role in diabetes-induced retinal vascular leakage. The purpose of this study is to examine the role of endoplasmic reticulum (ER) stress and the signaling pathway of ER stress-induced acti...
- FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
[作者：Mu, J; Pinkstaff, J; Li, ZH; Skidmore, L; Li, NN; Myler, H; Dallas-Yang, Q; Putnam, AM; Yao, J; Bussell, S; Wu, M; Norman, TC; Rodriguez, CG; Kimmel, B; Metzger, JM; Manibusan, A; Lee, D; Zaller, DM; Zhang, BB; DiMarchi, RD; Berger, JP; Axelrod, DW,期刊：Diabetes, 页码：505-512 , 文章类型： Article，,卷期：2012年61-2]
- Fibroblast growth factor 21 (FGF21) mitigates many of the pathogenic features of type 2 diabetes, despite a short circulating half-life. PEGylation is a proven approach to prolonging the duration of action while enhancin...
- Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
[作者：Winkler, R; Benz, V; Clemenz, M; Bloch, M; Foryst-Ludwig, A; Wardat, S; Witte, N; Trappiel, M; Namsolleck, P; Mai, K; Spranger, J; Matthias, G; Roloff, T; Truee, O; Kappert, K; Schupp, M; Matthias, P; Kintscher, U,期刊：Diabetes, 页码：513-523 , 文章类型： Article，,卷期：2012年61-2]
- In the current study, we investigated the importance of histone deacetylase (HDAC)6 for glucocorticoid receptor-mediated effects on glucose metabolism and its potential as a therapeutic target for the prevention of gluco...
- Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
[作者：Marquez, M; Huyvaert, M; Perry, JRB; Pearson, RD; Falchi, M; Morris, AP; Vivequin, S; Lobbens, S; Yengo, L; Gaget, S; Pattou, F; Poulain-Godefroy, O; Charpentier, G; Carlsson, LMS; Jacobson, P; Sjostrom, L; Lantieri, O; Heude, B; Walley, A; Balkau, B; Marre, M; Froguel, P; Cauchi, S,期刊：Diabetes, 页码：524-530 , 文章类型： Article，,卷期：2012年61-2]
- It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group Al (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to co...
- A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
[作者：Kwak, SH; Kim, SH; Cho, YM; Go, MJ; Cho, YS; Choi, SH; Moon, MK; Jung, HS; Shin, HD; Kang, HM; Cho, NH; Lee, IK; Kim, SY; Han, BG; Jang, HC; Park, KS,期刊：Diabetes, 页码：531-541 , 文章类型： Article，,卷期：2012年61-2]
- Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. In the stage 1 genome scan, 46...
- Global DNA Methylation Is Associated With Insulin Resistance A Monozygotic Twin Study
[作者：Zhao, JY; Goldberg, J; Bremner, JD; Vaccarino, V,期刊：Diabetes, 页码：542-546 , 文章类型： Article，,卷期：2012年61-2]
- Insulin resistance OR), the hallmark of type 2 diabetes, may be under epigenetic control. This study examines the association between global DNA methylation and IR using 84 monozygotic twin pairs. IR was estimated using ...
- The L-alpha-Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity
[作者：Moreno-Navarrete, JM; Catalan, V; Whyte, L; Diaz-Arteaga, A; Vazquez-Martinez, R; Rotellar, F; Guzman, R; Gomez-Ambrosi, J; Pulido, MR; Russell, WR; Imbernon, M; Ross, RA; Malagon, MM; Dieguez, C; Fernandez-Real, JM; Fruhbeck, G; Nogueiras, R,期刊：Diabetes, 页码：281-291 , 文章类型： Article，,卷期：2012年61-2]
- GPR55 is a putative cannabinoid receptor, and L-alpha-lysophosphatidylinositol (LP I) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 ...
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