- Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes
[作者：Dutta, T; Chai, HS; Ward, LE; Ghosh, A; Persson, XMT; Ford, GC; Kudva, YC; Sun, ZF; Asmann, YW; Kocher, JPA; Nair, KS,期刊：Diabetes, 页码：1004-1016 , 文章类型： Article，,卷期：2012年61-5]
- Insulin regulates many cellular processes, but the full impact of insulin deficiency on cellular functions remains to be defined. Applying a mass spectrometry-based nontargeted metabolomics approach, we report here alter...
- The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes
[作者：Constantin-Teodosiu, D; Constantin, D; Stephens, F; Laithwaite, D; Greenhaff, PL,期刊：Diabetes, 页码：1017-1024 , 文章类型： Article，,卷期：2012年61-5]
- High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohydrate (CHO) oxidation, which contributes to muscle insulin resistance. We aimed to reveal molecular changes underpinning this process in re...
- Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys
[作者：Willette, AA; Bendlin, BB; Colman, RJ; Kastman, EK; Field, AS; Alexander, AL; Sridharan, A; Allison, DB; Anderson, R; Voytko, ML; Kemnitz, JW; Weindruch, RH; Johnson, SC,期刊：Diabetes, 页码：1036-1042 , 文章类型： Article，,卷期：2012年61-5]
- Insulin signaling dysregulation is related to neural atrophy in hippocampus and other areas affected by neurovascular and neurodegenerative disorders. It is not known if long-term calorie restriction (CR) can ameliorate ...
- Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System
[作者：Bruinstroop, E; Pei, L; Ackermans, MT; Foppen, E; Borgers, AJ; Kwakkel, J; Alkemade, A; Fliers, E; Kalsbeek, A,期刊：Diabetes, 页码：1043-1050 , 文章类型： Article，,卷期：2012年61-5]
- Excessive secretion of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to diabetic dyslipidemia. Earlier studies have indicated a possible role for the hypothalamus and autonomic nervous system in t...
- Loss of AMP-Activated Protein Kinase-alpha 2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle
[作者：Wang, P; Zhang, RY; Song, J; Guan, YF; Xu, TY; Du, H; Viollet, B; Miao, CY,期刊：Diabetes, 页码：1051-1061 , 文章类型： Article，,卷期：2012年61-5]
- Whether the well-known metabolic switch AMP-activated protein kinase (AMPK) is involved in the insulin-sensitizing effect of calorie restriction (CR) is unclear. In this study, we investigated the role of AMPK in the ins...
- Liver X Receptor alpha Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene
[作者：Zhao, LF; Iwasaki, Y; Nishiyama, M; Taguchi, T; Tsugita, M; Okazaki, M; Nakayama, S; Kambayashi, M; Fujimoto, S; Hashimoto, K; Murao, K; Terada, Y,期刊：Diabetes, 页码：1062-1071 , 文章类型： Article，,卷期：2012年61-5]
- The activity of 6-phosphofructo-1-kinase is strictly controlled by fructose-2,6-bisphosphate, the level of which is regulated by another enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2/FBP2). PFK2/FBP2...
- Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis
[作者：McInnes, KJ; Smith, LB; Hunger, NI; Saunders, PTK; Andrew, R; Walker, BR,期刊：Diabetes, 页码：1072-1081 , 文章类型： Article，,卷期：2012年61-5]
- Testosterone deficiency is epidemic in obese ageing males with type 2 diabetes, but the direction of causality remains unclear. Testosterone-deficient males and global androgen receptor (AR) knockout mice are insulin res...
- Diabetes-Associated Common Genetic Variation and Its Association With GLP-1 Concentrations and Response to Exogenous GLP-1
[作者：Smushkin, G; Sathananthan, M; Sathananthan, A; Dalla Man, C; Micheletto, F; Zinsmeister, AR; Cobelli, C; Vella, A,期刊：Diabetes, 页码：1082-1089 , 文章类型： Article，,卷期：2012年61-5]
- The mechanisms by which common genetic variation predisposes to type 2 diabetes remain unclear. The disease-associated variants in TCF7L2 (rs7903146) and WFS1 (rs10010131) have been shown to affect response to exogenous ...
- GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance
[作者：Bienso, RS; Ringholm, S; Kiilerich, K; Aachmann-Andersen, NJ; Krogh-Madsen, B; Guerra, B; Plomgaard, P; van Hall, G; Treebak, JT; Saltin, B; Lundby, C; Calbet, JAL; Pilegaard, H; Wojtaszewski, JFP,期刊：Diabetes, 页码：1090-1099 , 文章类型： Article，,卷期：2012年61-5]
- To elucidate the molecular mechanisms behind physical inactivity-induced insulin resistance in skeletal muscle, 12 young, healthy male subjects completed 7 days of bed rest with vastus lateralis muscle biopsies obtained ...
- HDLs Protect Pancreatic beta-Cells Against ER Stress by Restoring Protein Folding and Trafficking
[作者：Petremand, J; Puyal, J; Chatton, JY; Duprez, J; Allagnat, F; Frias, M; James, RW; Waeber, G; Jonas, JC; Widmann, C,期刊：Diabetes, 页码：1100-1111 , 文章类型： Article，,卷期：2012年61-5]
- Endoplasmic reticulum (ER) homeostasis alteration contributes to pancreatic beta-cell dysfunction and death and favors the development of diabetes. In this study, we demonstrate that HDLs protect beta-cells against ER st...
- The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
[作者：Visinoni, S; Khalid, NFI; Joannides, CN; Shulkes, A; Yim, M; Whitehead, J; Tiganis, T; Lamont, BJ; Favaloro, JM; Proietto, J; Andrikopoulos, S; Fam, BC,期刊：Diabetes, 页码：1122-1132 , 文章类型： Article，,卷期：2012年61-5]
- Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only to regulate glucose or has other metabolic consequenc...
- Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
[作者：Ding, GL; Wang, FF; Shu, J; Tian, S; Jiang, Y; Zhang, D; Wang, N; Luo, Q; Zhang, Y; Jin, F; Leung, PCK; Sheng, JZ; Huang, HF,期刊：Diabetes, 页码：1133-1142 , 文章类型： Article，,卷期：2012年61-5]
- Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved and the possibilities of transgenerational transmission are still unclear. We ...
- Loss of HGF/c-Met Signaling in Pancreatic beta-Cells Leads to Incomplete Maternal beta-Cell Adaptation and Gestational Diabetes Mellitus
[作者：Demirci, C; Ernst, S; Alvarez-Perez, JC; Rosa, T; Valle, S; Shridhar, V; Casinelli, GP; Alonso, LC; Vasavada, RC; Garcia-Ocana, A,期刊：Diabetes, 页码：1143-1152 , 文章类型： Article，,卷期：2012年61-5]
- Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the beta-cell. However, whether HGF/c-Met has a role in maternal beta-cell adaptation during pregnancy is unknown. To address this issue, we charac...
- Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 alpha (PGC-1 alpha) Enhances Engraftment and Angiogenesis of Mesenchymal Stem Cells in Diabetic Hindlimb Ischemia
[作者：Lu, DB; Zhang, L; Wang, HH; Zhang, Y; Liu, J; Xu, J; Liang, ZW; Deng, WQ; Jiang, YZ; Wu, QA; Li, SF; Ai, ZH; Zhong, YX; Ying, Y; Liu, HY; Gao, F; Zhang, ZH; Chen, B,期刊：Diabetes, 页码：1153-1159 , 文章类型： Article，,卷期：2012年61-5]
- To examine whether the peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), a key regulator linking angiogenesis and metabolism, could enhance the engraftment and angiogenesis of mesenchyma...
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