- Local Zones of Endoplasmic Reticulum Complexity Confine Cargo in Neuronal Dendrites
[作者：Cui-Wang, TT; Hanus, C; Cui, T; Helton, T; Bourne, J; Watson, D; Harris, KM; Ehlers, MD,期刊：Cell, 页码：309-321 , 文章类型： Article，,卷期：2012年148-1-2]
- Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER) for variable periods that are typically rate limiting for plasma membrane delivery. In neurons, the ER extends for hundreds of micro...
- Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages
[作者：Schmidt, D; Schwalie, PC; Wilson, MD; Ballester, B; Goncalves, A; Kutter, C; Brown, GD; Marshall, A; Flicek, P; Odom, DT,期刊：Cell, 页码：335-348 , 文章类型： Article，,卷期：2012年148-1-2]
- CTCF-binding locations represent regulatory sequences that are highly constrained over the course of evolution. To gain insight into how these DNA elements are conserved and spread through the genome, we defined the full...
- EMT and Dissemination Precede Pancreatic Tumor Formation
[作者：Rhim, AD; Mirek, ET; Aiello, NM; Maitra, A; Bailey, JM; McAllister, F; Reichert, M; Beatty, GL; Rustgi, AK; Vonderheide, RH; Leach, SD; Stanger, BZ,期刊：Cell, 页码：349-361 , 文章类型： Article，,卷期：2012年148-1-2]
- Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and trac...
- Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies
[作者：Haeno, H; Gonen, M; Davis, MB; Herman, JM; Iacobuzio-Donahue, CA; Michor, F,期刊：Cell, 页码：362-375 , 文章类型： Article，,卷期：2012年148-1-2]
- Pancreatic cancer is a leading cause of cancer-related death, largely due to metastatic dissemination. We investigated pancreatic cancer progression by utilizing a mathematical framework of metastasis formation together ...
- Lineage Tracing
[作者：Kretzschmar, K; Watt, FM,期刊：Cell, 页码：33-45 , 文章类型： Article，,卷期：2012年148-1-2]
- Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19th century, lineage tracing is now an essential tool for studying s...
- Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
[作者：Rausch, T; Jones, DTW; Zapatka, M; Stutz, AM; Zichner, T; Weischenfeldt, J; Jager, N; Remke, M; Shih, D; Northcott, PA; Pfaff, E; Tica, J; Wang, Q; Massimi, L; Witt, H; Bender, S; Pleier, S; Cin, H; Hawkins, C; Beck, C; von Deimling, A; Hans, V; Brors, B; Eils, R; Scheurlen, W; Blake, J; Benes, V; Kulozik, AE; Witt, O; Martin, D; Zhang, C; Porat, R; Merino, DM; Wasserman, J; Jabado, N; Fontebasso, A; Bullinger, L; Rucker, FG; Dohner, K; Dohner, H; Koster, J; Molenaar, JJ; Versteeg, R; Kool, M; Tabori, U; Malkin, D; Korshunov, A; Taylor, MD; Lichter, P; Pfister, SM; Korbel, JO,期刊：Cell, 页码：59-71 , 文章类型： Article，,卷期：2012年148-1-2]
- Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event...
- Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer
[作者：Li, Z; Tuteja, G; Schug, J; Kaestner, KH,期刊：Cell, 页码：72-83 , 文章类型： Article，,卷期：2012年148-1-2]
- Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with significantly higher incidence in males, an effect that is dependent on sex hormones. The molecular mechanisms by which estrogens prev...
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