- TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers
[作者：Singh, A; Sweeney, MF; Yu, M; Burger, A; Greninger, P; Benes, C; Haber, DA; Settleman, J,期刊：Cell, 页码：639-650 , 文章类型： Article，,卷期：2012年148-4]
- Colon cancers frequently harbor KRAS mutations, yet only a subset of KRAS mutant colon cancer cell lines are dependent upon KRAS signaling for survival. In a screen for kinases that promote survival of KRAS-dependent col...
- Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
[作者：Hu, J; Hwang, SS; Liesa, M; Gan, BY; Sahin, E; Jaskelioff, M; Ding, ZH; Ying, HQ; Boutin, AT; Zhang, HL; Johnson, S; Ivanova, E; Kost-Alimova, M; Protopopov, A; Wang, YA; Shirihai, OS; Chin, L; DePinho, RA,期刊：Cell, 页码：651-663 , 文章类型： Article，,卷期：2012年148-4]
- To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/)-mice eng...
- RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
[作者：Tavares, L; Dimitrova, E; Oxley, D; Webster, J; Poot, R; Demmers, J; Bezstarosti, K; Taylor, S; Ura, H; Koide, H; Wutz, A; Vidal, M; Elderkin, S; Brockdorff, N,期刊：Cell, 页码：664-678 , 文章类型： Article，,卷期：2012年148-4]
- Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene silencing during differentiation and development. PRC1 recruitment is generally attributed to interaction of the chromodomain of...
- Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats
[作者：Liu, CR; Chang, CR; Chern, Y; Wang, TH; Hsieh, WC; Shen, WC; Chang, CY; Chu, IC; Deng, N; Cohen, SN; Cheng, TH,期刊：Cell, 页码：690-701 , 文章类型： Article，,卷期：2012年148-4]
- Lengthy trinucleotide repeats encoding polyglutamine (polyQ) stretches characterize the variant proteins of Huntington's disease and certain other inherited neurological disorders. Using a phenotypic screen to identify e...
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