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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA [作者：BRINCAT JEAN PIERRE; BROCCATELLI FABIO; SABATINI STEFANO; FROSINI MARIA; NERI ANNALISA; KAATZ GLENN W; CRUCIANI GABRIELE; CAROSATI EMANUELE,期刊：ACS Medicinal Chemistry Letters, 页码：248-251 , 文章类型： Article，,卷期：2012年3-3] Thirty-two diverse compounds were evaluated for their ability to inhibit both Pgp-mediated efflux in mouse T-lymphoma L5178 MDR1 and NorA-mediated efflux in S. aureus SA-1199B. Only four compounds were strong inhibitors ... Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity [作者：CHOBANIAN HARRY R; GUO YAN; LIU PING; CHIODA MARC; LANZA THOMAS J JR; CHANG LINDA; KELLY THERESA M; KAN YANQING; PALYHA OKSANA; GUAN XIAOMING; MARSH DONALD J; METZGER JOSEPH M; GORSKI JUDITH N; RAUSTAD KATE; WANG SHENGPING; STRACK ALISON M; MILLER RANDY; PANG JIANMEI; MADEIRA MARIA; LYONS KATHY; DRAGOVIC JASMINKA; REITMAN MARC L; NARGUND RAVI P; LIN LINUS S,期刊：ACS Medicinal Chemistry Letters, 页码：252-256 , 文章类型： Article，,卷期：2012年3-3] Extensive structure activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzocliazepine sulfonamide series, led to a potent, brain penetrant and selective compound with exc... NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals [作者：KODELA RAVINDER; CHATTOPADHYAY MITALI; KASHFI KHOSROW,期刊：ACS Medicinal Chemistry Letters, 页码：257-262 , 文章类型： Article，,卷期：2012年3-3] A series of new hybrids of aspirin (ASA), bearing both nitric oxide (NO) and hydrogen sulfide (H2S)-releasing moieties were synthesized and designated as NOSH compounds (1-4). NOSH-1 (4-(3-thioxo-3H-1,2-dithiol-5-yl) phe... Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site (vol 2, pg 538, 2011) [作者：MARYANOFF BRUCE E; ONEILL JOHN C; MCCOMSEY DAVID F; YABUT STEPHEN C; LUCI DIANE K; JORDAN ALFONZO D JR; MASUCCI JOHN A; JONES WILLIAM J; ABAD MARTA C; GIBBS ALAN C; PETROUNIA IOANNA,期刊：ACS Medicinal Chemistry Letters, 页码：263-263 , 文章类型： Correction，,卷期：2012年3-3]