Microtubules (MTs) composed of alpha beta-tubulin heterodimers are highly dynamic polymers, whose stability can be regulated by numerous endogenous. and exogenous factors. Both the antimitotic drug Taxol and microtubule-...
Changes in glycosylation are correlated to disease and associated with differentiation processes. Experimental tools are needed to investigate the physiological implications of these changes either by labeling of the mod...
The human immunodeficiency virus type-1 (HIV-1) capsid protein (CA) plays a critical role in the viral life cycle. The C-terminal domain (CTD) of CA binds to human lysyl-tRNA synthetas (hLysRS), and this interaction faci...
GIPC (GAIP-interacting protein, C terminus) represents a new target class for the discovery of chemotherapeutics. While many of the current generation of anticancer agents function by directly binding to intracellular ki...