- Antigen-Specific CD4(+) T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC Class II Signaling
[作者：Nagaraj, S; Nelson, A; Youn, JI; Cheng, PY; Quiceno, D; Gabrilovich, DI,期刊：Cancer research, 页码：928-938 , 文章类型： Article，,卷期：2012年72-4]
- Myeloid-derived suppressor cells (MDSC) play a major role in cancer-related immune suppression, yet the nature of this suppression remains controversial. In this study, we evaluated the ability of MDSCs to elicit CD4(+) ...
- Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors
[作者：Boidot, R; Vegran, F; Meulle, A; Le Breton, A; Dessy, C; Sonveaux, P; Lizard-Nacol, S; Feron, O,期刊：Cancer research, 页码：939-948 , 文章类型： Article，,卷期：2012年72-4]
- The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel mitochondrial respiration, the role of M...
- Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
[作者：Doe, MR; Ascano, JM; Kaur, M; Cole, MD,期刊：Cancer research, 页码：949-957 , 文章类型： Article，,卷期：2012年72-4]
- c-Myc is frequently overexpressed in tumors and plays an important role in the regulation of cancer metabolism. Hypoxia-inducible factor-1 (HIF1), the master regulator of the hypoxic response, enhances tumorigenesis and ...
- A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D
[作者：Ting, HJ; Yasmin-Karim, S; Yan, SJ; Hsu, JW; Lin, TH; Zeng, WS; Messing, J; Sheu, TJ; Bao, BY; Li, WX; Messing, E; Lee, YF,期刊：Cancer research, 页码：958-968 , 文章类型： Article，,卷期：2012年72-4]
- Both epidemiologic and laboratory studies have shown the chemopreventive effects of 1 alpha,25-dihydroxyvitamin D-3 (1,25-VD) in tumorigenesis. However, understanding of the molecular mechanism by which 1,25-VD prevents ...
- Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
[作者：Su, F; Bradley, WD; Wang, QQ; Yang, H; Xu, LZ; Higgins, B; Kolinsky, K; Packman, K; Kim, MJ; Trunzer, K; Lee, RJ; Schostack, K; Carter, J; Albert, T; Germer, S; Rosinski, J; Martin, M; Simcox, ME; Lestini, B; Heimbrook, D; Bollag, G,期刊：Cancer research, 页码：969-978 , 文章类型： Article，,卷期：2012年72-4]
- A high percentage of patients with BRAF(V600E) mutant melanomas respond to the selective RAF inhibitor vemurafenib (RG7204, PLX4032) but resistance eventually emerges. To better understand the mechanisms of resistance, w...
- Histone Deacetylase Inhibition Increases Levels of Choline Kinase a and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers
[作者：Beloueche-Babari, M; Arunan, V; Troy, H; Poele, RHT; Fong, ACWT; Jackson, LE; Payne, GS; Griffiths, JR; Judson, IR; Workman, P; Leach, MO; Chung, YL,期刊：Cancer research, 页码：990-1000 , 文章类型： Article，,卷期：2012年72-4]
- Histone deacetylase (HDAC) inhibitors are currently approved for cutaneous T-cell lymphoma and are in midlate stage trials for other cancers. The HDAC inhibitors LAQ824 and SAHA increase phosphocholine (PC) levels in hum...
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