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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone [作者：Donati, G; Montanaro, L; Derenzini, M,期刊：Cancer research, 页码：1602-1607 , 文章类型： Article，,卷期：2012年72-7] Cell growth is a prerequisite for cell proliferation, and ribosome biogenesis is a limiting factor for cell growth. In mammalian cells, the tumor suppressor p53 has been shown to induce cell-cycle arrest in response to i... PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma [作者：Brenner, JC; Feng, FY; Han, S; Patel, S; Goyal, SV; Bou-Maroun, LM; Liu, M; Lonigro, R; Prensner, JR; Tomlins, SA; Chinnaiyan, AM,期刊：Cancer research, 页码：1608-1613 , 文章类型： Article，,卷期：2012年72-7] Ewing's sarcoma family of tumors (ESFT) refers to aggressive malignancies which frequently harbor characteristic EWS-FLI1 or EWS-ERG genomic fusions. Here, we report that these fusion products interact with the DNA damag... Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity [作者：Little, SE; Popov, S; Jury, A; Bax, DA; Doey, L; Al-Sarraj, S; Jurgensmeier, JM; Jones, C,期刊：Cancer research, 页码：1614-1620 , 文章类型： Article，,卷期：2012年72-7] Intratumoral heterogeneity in human solid tumors represents a major barrier for the development of effective molecular treatment strategies, as treatment efficacies will reflect the molecular variegation in individual tu... Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L-Expressing Replicating Adenovirus: Assessment of Safety and Immunologic Responses in Patients [作者：Pesonen, S; Diaconu, I; Kangasniemi, L; Ranki, T; Kanerva, A; Pesonen, SK; Gerdemann, U; Leen, AM; Kairemo, K; Oksanen, M; Haavisto, E; Holm, SL; Karioja-Kallio, A; Kauppinen, S; Partanen, KPL; Laasonen, L; Joensuu, T; Alanko, T; Cerullo, V; Hemminki, A,期刊：Cancer research, 页码：1621-1631 , 文章类型： Article，,卷期：2012年72-7] The immunosuppressive environment of advanced tumors is a primary obstacle to the efficacy of immunostimulatory and vaccine approaches. Here, we report an approach to arm an oncolytic virus with CD40 ligand (CD40L) to st... Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics [作者：Harrold, JM; Straubinger, RM; Mager, DE,期刊：Cancer research, 页码：1632-1641 , 文章类型： Article，,卷期：2012年72-7] Combination chemotherapy represents the standard-of-care for non-Hodgkin lymphoma. However, the development of new therapeutic regimens is empirical and this approach cannot be used prospectively to identify novel or opt... Dissection of T-cell Antigen Specificity in Human Melanoma [作者：Andersen, RS; Thrue, CA; Junker, N; Lyngaa, R; Donia, M; Ellebaek, E; Svane, IM; Schumacher, TN; Straten, PT; Hadrup, SR,期刊：Cancer research, 页码：1642-1650 , 文章类型： Article，,卷期：2012年72-7] Tumor-infiltrating lymphocytes (TIL) isolated from melanoma patients and expanded in vitro by interleukin (IL)-2 treatment can elicit therapeutic response after adoptive transfer, but the antigen specificities of the T c... Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer [作者：John, LB; Howland, LJ; Flynn, JK; West, AC; Devaud, C; Duong, CP; Stewart, TJ; Westwood, JA; Guo, ZS; Bartlett, DL; Smyth, MJ; Kershaw, MH; Darcy, PK,期刊：Cancer research, 页码：1651-1660 , 文章类型： Article，,卷期：2012年72-7] Oncolytic virotherapy using vaccinia virus (Vv) has shown some encouraging antitumor responses in mouse models and patients, but the breadth of efficacy in clinical trials has been somewhat limited. Given that antitumor ... Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy [作者：Van Lint, S; Goyvaerts, C; Maenhout, S; Goethals, L; Disy, A; Benteyn, D; Pen, J; Bonehill, A; Heirman, C; Breckpot, K; Thielemans, K,期刊：Cancer research, 页码：1661-1671 , 文章类型： Article，,卷期：2012年72-7] The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to TAAs to dendritic cells (DC). In thi... Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy [作者：Noguchi, T; Kato, T; Wang, LN; Maeda, Y; Ikeda, H; Sato, E; Knuth, A; Gnjatic, S; Ritter, G; Sakaguchi, S; Old, LJ; Shiku, H; Nishikawa, H,期刊：Cancer research, 页码：1672-1682 , 文章类型： Article，,卷期：2012年72-7] Monoclonal antibody (mAb) therapy against tumor antigens expressed on the tumor surface is associated with clinical benefit. However, many tumor antigens are intracellular molecules that generally would not be considered... Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer [作者：Cubillos-Ruiz, JR; Baird, JR; Tesone, AJ; Rutkowski, MR; Scarlett, UK; Camposeco-Jacobs, AL; Anadon-Arnillas, J; Harwood, NM; Korc, M; Fiering, SN; Sempere, LF; Conejo-Garcia, JR,期刊：Cancer research, 页码：1683-1693 , 文章类型： Article，,卷期：2012年72-7] Modulating the activity of miRNAs provides opportunities for novel cancer interventions. However, low bioavailability and poor cellular uptake are major challenges for delivering miRNA mimetics specifically to tumor cell... Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy [作者：Wong, CSF; Sceneay, J; House, CM; Halse, HM; Liu, MCP; George, J; Hunnam, TCUP; Parker, BS; Haviv, I; Ronai, Z; Cullinane, C; Bowtell, DD; Moller, A,期刊：Cancer research, 页码：1694-1704 , 文章类型： Article，,卷期：2012年72-7] Tumor hypoxia is associated with resistance to antiangiogenic therapy and poor prognosis. The Siah E3 ubiquitin ligases regulate the hypoxic response pathway by modulating the turnover of the master proangiogenic transcr... Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer [作者：Vinuesa, AG; Sancho, R; Garcia-Limones, C; Behrens, A; ten Dijke, P; Calzado, MA; Munoz, E,期刊：Cancer research, 页码：1705-1716 , 文章类型： Article，,卷期：2012年72-7] Neuroinflammation driven by the vanilloid-type ion channel receptor transient receptor potential vanilloid type 1 (TRPV-1) is suspected to play a role in the pathophysiology of inflammatory bowel disease. Because inflamm... Cancer Vaccination Drives Nanog-Dependent Evolution of Tumor Cells toward an Immune-Resistant and Stem-like Phenotype [作者：Noh, KH; Lee, YH; Jeon, JH; Kang, TH; Mao, CP; Wu, TC; Kim, TW,期刊：Cancer research, 页码：1717-1727 , 文章类型： Article，,卷期：2012年72-7] Due to the exquisite specificity and potency of the immune system, vaccination is in theory the most precise and powerful approach for controlling cancer. However, current data from clinical trials indicate that vaccinat... ROR alpha Suppresses Breast Tumor Invasion by Inducing SEMA3F Expression [作者：Xiong, GF; Wang, C; Evers, BM; Zhou, BHP; Xu, R,期刊：Cancer research, 页码：1728-1739 , 文章类型： Article，,卷期：2012年72-7] Inactivation of tumor suppressors and inhibitory microenvironmental factors is necessary for breast cancer invasion; therefore, identifying those suppressors and factors is crucial not only to advancing our knowledge of ... Dmp1 Physically Interacts with p53 and Positively Regulates p53's Stability, Nuclear Localization, and Function [作者：Frazier, DP; Kendig, RD; Kai, F; Maglic, D; Sugiyama, T; Morgan, RL; Fry, EA; Lagedrost, SJ; Sui, GC; Inoue, K,期刊：Cancer research, 页码：1740-1750 , 文章类型： Article，,卷期：2012年72-7] The transcription factor Dmp1 is a Ras/HER2-activated haplo-insufficient tumor suppressor that activates the Arf/p53 pathway of cell-cycle arrest. Recent evidence suggests thatDmp1 may activate p53 independently of Arfin... MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1 alpha and Enhances beta-Catenin Signaling [作者：Zhang, PY; Bill, K; Liu, JH; Young, E; Peng, TS; Bolshakov, S; Hoffman, A; Song, YC; Demicco, EG; Terrada, DL; Creighton, CJ; Anderson, ML; Lazar, AJ; Calin, GG; Pollock, RE; Lev, D,期刊：Cancer research, 页码：1751-1762 , 文章类型： Article，,卷期：2012年72-7] Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis for its progression. miRNA...