- Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
[作者:Srinivasan, M; Flynn, R; Price, A; Ranger, A; Browning, JL; Taylor, PA; Ritz, J; Antin, JH; Murphy, WJ; Luznik, L; Shlomchik, MJ; Panoskaltsis-Mortari, A; Blazar, BR,期刊:Blood, 页码:1570-1580 , 文章类型: Article,,卷期:2012年119-6]
- Chronic GVHD (cGVHD) poses a significant risk for HSCT patients. Preclinical development of new therapeutic modalities has been hindered by models with pathologic findings that may not simulate the development of human c...
- Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants
[作者:Hongo, D; Tang, XB; Dutt, S; Nador, RG; Strober, S,期刊:Blood, 页码:1581-1589 , 文章类型: Article,,卷期:2012年119-6]
- We used a model of combined bone marrow and heart transplantation, in which tolerance and stable chimerism is induced after conditioning with fractionated irradiation of the lymphoid tissues and anti-T-cell antibodies. G...
- Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing
[作者:Sun, K; Alvarez, M; Ames, E; Barao, I; Chen, MY; Longo, DL; Redelman, D; Murphy, WJ,期刊:Blood, 页码:1590-1598 , 文章类型: Article,,卷期:2012年119-6]
- Natural killer (NK) cells can mediate the rejection of bone marrow allografts and exist as subsets based on expression of inhibitory/activating receptors that can bind MHC. In vitro data have shown that NK subsets bearin...
- A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
[作者:Arnold, DM; Heddle, NM; Carruthers, J; Cook, DJ; Crowther, MA; Meyer, RM; Liu, Y; Cook, RJ; McLeod, A; MacEachern, JA; Mangel, J; Anderson, D; Vickars, L; Tinmouth, A; Schuh, AC; Kelton, JG,期刊:Blood, 页码:1356-1362 , 文章类型: Article,,卷期:2012年119-6]
- The benefit of adding rituximab to standard treatment in nonsplenectomized patients with primary immune thrombocytopenia (ITP) is uncertain. We performed a pilot randomized trial to determine the feasibility of recruitme...
- Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera
[作者:Alvarez-Larran, A; Pereira, A; Cervantes, F; Arellano-Rodrigo, E; Hernandez-Boluda, JC; Ferrer-Marin, F; Angona, A; Gomez, M; Muina, B; Guillen, H; Teruel, A; Bellosillo, B; Burgaleta, C; Vicente, V; Besses, C,期刊:Blood, 页码:1363-1369 , 文章类型: Article,,卷期:2012年119-6]
- Criteria of response and definition of resistance and intolerance to hydroxyurea (HU) in polycythemia vera (PV) were proposed by the European LeukemiaNet (ELN). Such criteria were evaluated in 261 PV patients (median fol...
- The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
[作者:Nijnik, A; Clare, S; Hale, C; Raisen, C; McIntyre, RE; Yusa, K; Everitt, AR; Mottram, L; Podrini, C; Lucas, M; Estabel, J; Goulding, D; Adams, N; Ramirez-Solis, R; White, JK; Adams, DJ; Hancock, REW; Dougan, G,期刊:Blood, 页码:1370-1379 , 文章类型: Article,,卷期:2012年119-6]
- Stem cell differentiation and lineage specification depend on coordinated programs of gene expression, but our knowledge of the chromatin-modifying factors regulating these events remains incomplete. Ubiquitination of hi...
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