- The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis
[作者：Wu, Y; Ahmad, SS; Zhou, JS; Wang, L; Cully, MP; Essex, DW,期刊：Blood, 页码：1737-1746 , 文章类型： Article，,卷期：2012年119-7]
- A close homologue to protein disulfide isomerase (PDI) called ERp57 forms disulfide bonds in glycoproteins in the endoplasmic reticulum and is expressed on the platelet surface. We generated 2 rabbit Abs to ERp57. One Ab...
- CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development
[作者：Finney, BA; Schweighoffer, E; Navarro-Nunez, L; Benezech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Sousa, CRE; Tybulewicz, VLJ; Watson, SP,期刊：Blood, 页码：1747-1756 , 文章类型： Article，,卷期：2012年119-7]
- The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic devel...
- Transfusion-related acute lung injury: incidence and risk factors
[作者：Toy, P; Gajic, O; Bacchetti, P; Looney, MR; Gropper, MA; Hubmayr, R; Lowell, CA; Norris, PJ; Murphy, EL; Weiskopf, RB; Wilson, G; Koenigsberg, M; Lee, D; Schuller, R; Wu, P; Grimes, B; Gandhi, MJ; Winters, JL; Mair, D; Hirschler, N; Rosen, RS; Matthay, MA,期刊：Blood, 页码：1757-1767 , 文章类型： Article，,卷期：2012年119-7]
- Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To determine TRALI incidence by prospective, active surveillance and to identify risk factors by a case-control study, ...
- Normalization of pre-ASCT, FDG-PET imaging with second-line, non-cross-resistant, chemotherapy programs improves event-free survival in patients with Hodgkin lymphoma
[作者：Moskowitz, CH; Matasar, MJ; Zelenetz, AD; Nimer, SD; Gerecitano, J; Hamlin, P; Horwitz, S; Moskowitz, AJ; Noy, A; Palomba, L; Perales, MA; Portlock, C; Straus, D; Maragulia, JC; Schoder, H; Yahalom, J,期刊：Blood, 页码：1665-1670 , 文章类型： Article，,卷期：2012年119-7]
- We previously reported that remission duration < 1 year, extranodal disease, and B symptoms before salvage chemotherapy (SLT) can stratify relapsed or refractory Hodgkin lymphoma (HL) patients into favorable and unfavora...
- Blockade of prostaglandin E-2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells
[作者：Singh, P; Hoggatt, J; Hu, PR; Speth, JM; Fukuda, S; Breyer, RM; Pelus, LM,期刊：Blood, 页码：1671-1682 , 文章类型： Article，,卷期：2012年119-7]
- Dendritic cell (DC) homeostasis, like all mature blood cells, is maintained via hierarchal generation from hematopoietic precursors; however, little is known about the regulatory mechanisms governing DC generation. Here,...
- The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells
[作者：Ichii, M; Frank, MB; Iozzo, RV; Kincade, PW,期刊：Blood, 页码：1683-1692 , 文章类型： Article，,卷期：2012年119-7]
- Considerable information has accumulated about components of BM that regulate the survival, self-renewal, and differentiation of hematopoietic cells. In the present study, we investigated Wnt signaling and assessed its i...
- R-Ras is required for murine dendritic cell maturation and CD4(+) T-cell priming
[作者：Singh, G; Hashimoto, D; Yan, XC; Helft, J; Park, PJY; Ma, G; Qiao, RF; Kennedy, CR; Chen, SH; Merad, M; Chan, AM,期刊：Blood, 页码：1693-1701 , 文章类型： Article，,卷期：2012年119-7]
- R-Ras is a member of the RAS superfamily of small GTP-binding proteins. The physiologic function of R-Ras has not been fully elucidated. We found that R-Ras is expressed by lymphoid and nonlymphoid tissues and drasticall...
- Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes
[作者：Remmerswaal, EBM; Havenith, SHC; Idu, MM; van Leeuwen, EMM; van Donselaar, KAMI; ten Brinke, A; van der Bom-Baylon, N; Bemelman, FJ; van Lier, RAW; ten Berge, IJM,期刊：Blood, 页码：1702-1712 , 文章类型： Article，,卷期：2012年119-7]
- It is believed that the size of the CD8(+) T-cell pool is fixed and that with every new viral challenge, the size of the preexisting memory-cell population shrinks to make way for the new virus-specific cells. CMV-seropo...
- Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin
[作者：Chia, J; Thia, K; Brennan, AJ; Little, M; Williams, B; Lopez, JA; Trapani, JA; Voskoboinik, I,期刊：Blood, 页码：1713-1716 , 文章类型： Article，,卷期：2012年119-7]
- Mutations in the perforin gene (PRF1) are a common cause of the fatal immune dysregulation disorder, familial hemophagocytic lymphohistiocytosis (type 2 FHL, FHL2). Here we report a female infant born with biallelic PRF1...
- Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia
[作者：O'Callaghan, K; Lee, L; Nguyen, N; Hsieh, MY; Kaneider, NC; Klein, AK; Sprague, K; Van Etten, RA; Kuliopulos, A; Covic, L,期刊：Blood, 页码：1717-1725 , 文章类型： Article，,卷期：2012年119-7]
- The chemokine receptor CXCR4, which normally regulates stromal stem cell interactions in the bone marrow, is highly expressed on a variety of malignant hematologic cells, including lymphoma and lymphocytic leukemias. A n...
- Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
[作者：Paterson, A; Mockridge, CI; Adams, JE; Krysov, S; Potter, KN; Duncombe, AS; Cook, SJ; Stevenson, FK; Packham, G,期刊：Blood, 页码：1726-1736 , 文章类型： Article，,卷期：2012年119-7]
- B-cell receptor and microenvironment-derived signals promote accumulation of chronic lymphocytic leukemia (CLL) cells through increased proliferation and/or decreased apoptosis. In this study, we investigated the regulat...
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