- Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal Domain
[作者:McDonald, ET; Bortolus, M; Koteiche, HA; Mchaourab, HS,期刊:Biochemistry, 页码:1257-1268 , 文章类型: Article,,卷期:2012年51-6]
- Human small heat shock protein 27 (Hsp27) undergoes concentration-dependent equilibrium dissociation from an ensemble of large oligomers to a dimer. This phenomenon plays a critical role in Hsp27 chaperone activity in vi...
- Ion Binding and Internal Hydration in the Multidrug Resistance Secondary Active Transporter NorM Investigated by Molecular Dynamics Simulations
[作者:Vanni, S; Campomanes, P; Marcia, M; Rothlisberger, U,期刊:Biochemistry, 页码:1281-1287 , 文章类型: Article,,卷期:2012年51-6]
- Recently, a 3.65 angstrom resolution structure of the transporter, NorM from the multidrug and toxic compound extrusion family has been determined in the outward-facing conformation. This antiporter uses electrochemical ...
- Characterization of the Interface of the Bone Marrow Stromal Cell Antigen 2-Vpu Protein Complex via Computational Chemistry
[作者:Zhou, JM; Zhang, ZX; Mi, ZY; Wang, X; Zhang, Q; Li, XY; Liang, C; Cen, S,期刊:Biochemistry, 页码:1288-1296 , 文章类型: Article,,卷期:2012年51-6]
- Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of enveloped viruses from the cell surface. Various viral counter measures have been discovered, which allow viruses to escape BST-2 restriction. Human immu...
- Conformational Dynamics of Abasic DNA upon Interactions with AP Endonuclease 1 Revealed by Stopped-Flow Fluorescence Analysis
[作者:Kanazhevskaya, LY; Koval, VV; Vorobjev, YN; Fedorova, OS,期刊:Biochemistry, 页码:1306-1321 , 文章类型: Article,,卷期:2012年51-6]
- Apurinic/apyrimidinic (AP) sites are abundant DNA lesions arising from exposure to UV light, ionizing radiation, alkylating agents, and oxygen radicals. In human cells, AP endonuclease 1 (APE1) recognizes this mutagenic ...
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