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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   Toward a Detailed Description of the Pathways of Allosteric Communication in the GroEL Chaperonin through Atomistic Simulation [作者：Piggot, TJ; Sessions, RB; Burston, SG,期刊：Biochemistry, 页码：1707-1718 , 文章类型： Article，,卷期：2012年51-8] GroEL, along with its coprotein GroES, is essential for ensuring the correct folding of unfolded or newly synthesized proteins in bacteria. GroEL is a complex, allosteric molecule, composed of two heptameric rings stacke... Locked on One Side Only: Ground State Dynamics of the Outer Membrane Efflux Duct ToIC [作者：Raunest, M; Kandt, C,期刊：Biochemistry, 页码：1719-1729 , 文章类型： Article，,卷期：2012年51-8] Playing a major role in the expulsion of antibiotics and the secretion of cell toxins in conjunction with inner membrane transporters of three protein superfamilies, the outer membrane channel ToIC occurs in at least two... Amsacrine as a Topoisomerase II Poison: Importance of Drug-DNA Interactions [作者：Ketron, AC; Denny, WA; Graves, DE; Osheroff, N,期刊：Biochemistry, 页码：1730-1739 , 文章类型： Article，,卷期：2012年51-8] Amsacrine (m-AMSA) is an anticancer agent that displays activity against refractory acute leukemias as well as Hodgkin's and non-Hodgkin's lymphomas. The drug is comprised of an intercalative acridine moiety coupled to a... Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes [作者：Morar, M; Pengelly, K; Koteva, K; Wright, GD,期刊：Biochemistry, 页码：1740-1751 , 文章类型： Article，,卷期：2012年51-8] Macrolide antibiotics such as azithromycin and erythromycin are mainstays of modern antibacterial chemotherapy, and like all antibiotics, they are vulnerable to resistance. One mechanism of macrolide resistance is via dr... Platinated DNA Affects Zinc Finger Conformation. Interaction of a Platinated Single-Stranded Oligonucleotide and the C-Terminal Zinc Finger of Nucleocapsid Protein HIVNCp7 [作者：Quintal, S; Viegas, A; Erhardt, S; Cabrita, EJ; Farrell, NP,期刊：Biochemistry, 页码：1752-1761 , 文章类型： Article，,卷期：2012年51-8] This paper describes for the first time the intimate molecular details of the association between a platinated oligonucleotide and a zinc finger peptide. Site-specific platination of the guanine in a single-stranded hexa... Structure-Based Function Discovery of an Enzyme for the Hydrolysis of Phosphorylated Sugar Lactones [作者：Xiang, DF; Kolb, P; Fedorov, AA; Xu, CF; Fedorov, EV; Narindoshivili, T; Williams, HJ; Shoichet, BK; Almo, SC; Raushel, FM,期刊：Biochemistry, 页码：1762-1773 , 文章类型： Article，,卷期：2012年51-8] Two enzymes of unknown function from the cog1735 subset of the amidohydrolase superfamily (AHS), LMOf2365_2620 (Lmo2620) from Listeria monocytogenes str. 4b F2365 and Bh0225 from Bacillus halodurans C-125, were cloned, e... Determinants of Reactivity and Selectivity in Soluble Epoxide Hydrolase from Quantum Mechanics/Molecular Mechanics Modeling [作者：Lonsdale, R; Hoyle, S; Grey, DT; Ridder, L; Mulholland, AJ,期刊：Biochemistry, 页码：1774-1786 , 文章类型： Article，,卷期：2012年51-8] Soluble epoxide hydrolase (sEH) is an enzyme involved in drug metabolism that catalyzes the hydrolysis of epoxides to form their corresponding diols. sEH has a broad substrate range and shows high regio- and enantioselec... Mechanism of Inhibition of GluA2 AMPA Receptor Channel Opening by 2,3-Benzodiazepine Derivatives: Functional Consequences of Replacing a 7,8-Methylenedioxy with a 7,8-Ethylenedioxy Moiety [作者：Qneibi, MS; Micale, N; Grasso, S; Niu, L,期刊：Biochemistry, 页码：1787-1795 , 文章类型： Article，,卷期：2012年51-8] 2,3-Benzodiazepine (2,3-BDZ) compounds are a group of AMPA receptor inhibitors and are drug candidates for treating neurological diseases involving excessive AMPA receptor activity. We investigated the mechanism by which... Examining Protein Surface Structure in Highly Conserved Sequence Variants with Mass Spectrometry [作者：Tao, YQ; Julian, RR,期刊：Biochemistry, 页码：1796-1802 , 文章类型： Article，,卷期：2012年51-8] A simple mass spectrometry-based method capable of examining protein structure called SNAPP (selective non-covalent adduct protein probing) is used to evaluate the structural consequences of point mutations in naturally ... Activities of Topoisomerase I in Its Complex with SRSF1 [作者：Ishikawa, T; Krzysko, KA; Kowalska-Loth, B; Skrajna, AM; Czubaty, A; Girstun, A; Cieplak, MK; Lesyng, B; Staron, K,期刊：Biochemistry, 页码：1803-1816 , 文章类型： Article，,卷期：2012年51-8] Human DNA topoisomerase I (topo I) catalyzes DNA relaxation and phosphorylates SRSF1. Whereas the structure of topo I complexed with DNA has been resolved, the structure of topo Tin the complex with SRSF1 and structural ...