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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   Effector Role Reversal during Evolution: The Case of Frataxin in Fe-S Cluster Biosynthesis [作者：Bridwell-Rabb, J; Iannuzzi, C; Pastore, A; Barondeau, DP,期刊：Biochemistry, 页码：2506-2514 , 文章类型： Article，,卷期：2012年51-12] Human frataxin (FXN) has been intensively studied since the discovery that the FXN gene is associated with the neurodegenerative disease Friedreich's ataxia. Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) co... Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain alpha-Helical Bundle [作者：Harrison, JS; Koellhoffer, JF; Chandran, K; Lai, JR,期刊：Biochemistry, 页码：2515-2525 , 文章类型： Article，,卷期：2012年51-12] Marburg virus (MARV) and Ebola virus (EBOV) constitute the family Filoviridae of enveloped viruses (filoviruses) that cause severe hemorrhagic fever. Infection by MARV requires fusion between the host cell and viral memb... On the Mechanism of alpha C Polymer Formation in Fibrin [作者：Tsurupa, G; Pechik, I; Litvinov, RI; Hantgan, RR; Tjandra, N; Weisel, JW; Medved, L,期刊：Biochemistry, 页码：2526-2538 , 文章类型： Article，,卷期：2012年51-12] Our previous studies revealed that the fibrinogen alpha C-domains undergo conformational changes and adopt a physiologically active conformation upon their self-association into alpha C polymers in fibrin. In the present... Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption [作者：Jones, EM; Dubey, M; Camp, PJ; Vernon, BC; Biernat, J; Mandelkow, E; Majewski, J; Chi, EY,期刊：Biochemistry, 页码：2539-2550 , 文章类型： Article，,卷期：2012年51-12] The misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of Alzheimer's disease. However, the mechanisms of tau agg... Identification of Exosite Residues of Factor Xa Involved in Recognition of PAR-2 on Endothelial Cells [作者：Manithody, C; Yang, LK; Rezaie, AR,期刊：Biochemistry, 页码：2551-2557 , 文章类型： Article，,卷期：2012年51-12] Recent results have indicated that factor Xa (FXa) cleaves protease-activated receptor 2 (PAR-2) to elicit protective intracellular signaling responses in endothelial cells. In this study, we investigated the molecular d... Effects of the Oncogenic V664E Mutation on Membrane Insertion, Structure, and Sequence-Dependent Interactions of the Neu Transmembrane Domain in Micelles and Model Membranes: An Integrated Biophysical and Simulation Study [作者：Beevers, AJ; Nash, A; Saazar-Cancino, M; Scott, DJ; Notman, R; Dixon, AM,期刊：Biochemistry, 页码：2558-2568 , 文章类型： Article，,卷期：2012年51-12] Receptor tyrosine kinases bind ligands such as cytokines, hormones, and growth factors and regulate key cellular processes, including cell division. They are also implicated in the development of many types of cancer. On... Computational Prediction of Residues Involved in Fidelity Checking for DNA Synthesis in DNA Polymerase I [作者：Graham, SE; Syeda, F; Cisneros, GA,期刊：Biochemistry, 页码：2569-2578 , 文章类型： Article，,卷期：2012年51-12] Recent single-molecule Forster resonance energy transfer studies of DNA polymerase I have led to the proposal of a postinsertion fidelity-checking site. This site is hypothesized to ensure proper base pairing of the newl... Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable pi-Cation Latched Loop [作者：Goldstein, R; Cheng, JJ; Stec, B; Roberts, MF,期刊：Biochemistry, 页码：2579-2587 , 文章类型： Article，,卷期：2012年51-12] Staphylococcus aureus secretes a phosphatidylinositol-specific phospholipase C (PI-PLC) as a virulence factor that is unusual in exhibiting higher activity at acidic pH values than other enzymes in this class. We have de... Structural and Biochemical Characterization of the Childhood Cataract-Associated R76S Mutant of Human gamma D-Crystallin [作者：Ji, FL; Jung, JW; Gronenborn, AM,期刊：Biochemistry, 页码：2588-2596 , 文章类型： Article，,卷期：2012年51-12] Although a number of gamma D-crystallin mutations are associated with cataract formation, there is not a clear understanding of the molecular mechanism(s) that lead to this protein deposition disease. As part of our ongo... Antigen-Antibody Interactions and Structural Flexibility of a Femtomolar-Affinity Antibody [作者：Fukunishi, H; Shimada, J; Shiraishi, K,期刊：Biochemistry, 页码：2597-2605 , 文章类型： Article，,卷期：2012年51-12] The femtomolar-affinity mutant antibody (4M5.3) generated by directed evolution is interesting because of the potential of antibody engineering. In this study, the mutant and its wild type (4-4-20) were compared in terms... Catalytic Mechanism of Aromatic Prenylation by NphB [作者：Yang, Y; Miao, YP; Wang, B; Cui, GL; Merz, KM,期刊：Biochemistry, 页码：2606-2618 , 文章类型： Article，,卷期：2012年51-12] NphB is an aromatic prenyltransferase that catalyzes the attachment of a 10-carbon geranyl group to aromatic substrates. Importantly, NphB exhibits a rich substrate selectivity and product regioselectivity. A systematic ...