- Arg305 of Streptomyces L-glutamate oxidase plays a crucial role for substrate recognition
[作者:Utsumi, T; Arima, J; Sakaguchi, C; Tamura, T; Sasaki, C; Kusakabe, H; Sugio, S; Inagaki, K,期刊:Biochemical and Biophysical Research Communications, 页码:951-955 , 文章类型: Article,,卷期:2012年417-3]
- Recently, we have solved the crystal structure of L-glutamate oxidase (LGOX) from Streptomyces sp. X-119-6 (PDB code: 2E1M), the substrate specificity of which is strict toward L-glutamate. By a docking simulation using....
- Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37
[作者:Kelly, BJ; Diefenbach, E; Fraefel, C; Diefenbach, RJ,期刊:Biochemical and Biophysical Research Communications, 页码:961-965 , 文章类型: Article,,卷期:2012年417-3]
- The herpes simplex virus type 1 (HSV-1) structural tegument protein pUL37, which is conserved across the Helpesviridae family, is known to be essential for secondary envelopment during the egress of viral particles. To s...
- ETS1 promotes chemoresistance and invasion of paclitaxel-resistant, hormone-refractory PC3 prostate cancer cells by up-regulating MDR1 and MMP9 expression
[作者:Kato, T; Fujita, Y; Nakane, K; Kojima, T; Nozawa, Y; Deguchi, T; Ito, M,期刊:Biochemical and Biophysical Research Communications, 页码:966-971 , 文章类型: Article,,卷期:2012年417-3]
- ETS1, which belongs to the ETS transcription factor family, plays important roles in diverse aspects of cancer such as drug resistance and metastasis. In the present study, we examined the functional roles of ETS1 in pac...
- The Nogo receptor 2 is a novel substrate of Fbs1
[作者:Kern, F; Sarg, B; Stasyk, T; Hess, D; Lindner, H,期刊:Biochemical and Biophysical Research Communications, 页码:977-981 , 文章类型: Article,,卷期:2012年417-3]
- Members of the Nogo66 receptor family (NgR) are closely associated with nerve growth inhibition and plasticity in the CNS. All three members, NgR1. NgR2 and NgR3, are GPI anchored and highly glycosylated proteins. The bi...
- Abnormal DNA methylation of ITGAL (CD11a) in CD4+T cells from infants with biliary atresia
[作者:Dong, R; Zhao, R; Zheng, S; Zheng, YJ; Xiong, SD; Chu, YW,期刊:Biochemical and Biophysical Research Communications, 页码:986-990 , 文章类型: Article,,卷期:2012年417-3]
- Recent evidence indicates that alterations to epigenetic DNA methylation patterns contribute to many autoimmune diseases. Biliary atresia (BA) is a virus-induced autoimmune disease characterized by impaired T cells, whic...
- Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved in Arabidopsis root growth mediated by the bacterial quorum-sensing signals N-acyl-homoserine lactones
[作者:Jin, GP; Liu, F; Ma, H; Hao, SY; Zhao, Q; Bian, ZR; Jia, ZH; Song, SS,期刊:Biochemical and Biophysical Research Communications, 页码:991-995 , 文章类型: Article,,卷期:2012年417-3]
- Many Gram-negative bacteria use N-acyl-homoserine lactones (AHLs) as quorum sensing (QS) signaling molecules to coordinate their group behavior. Recently, it was shown that plants can perceive and respond to these bacter...
- Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping
[作者:Yao, X; Zha, WJ; Song, W; He, HY; Huang, M; Jazrawi, E; Lavender, P; Barnes, PJ; Adcock, IM; Durham, AL,期刊:Biochemical and Biophysical Research Communications, 页码:996-1001 , 文章类型: Article,,卷期:2012年417-3]
- Asthma is a chronic allergic disorder characterised by chronic inflammation. The balance of type I and type II (CD4+) T helper cells is of critical importance. In asthma there is an overexpression of T(H)2 cytokines, suc...
- Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation
[作者:Ma, T; Yamada, S; Ichwan, SJA; Iseki, S; Ohtani, K; Otsu, M; Ikeda, MA,期刊:Biochemical and Biophysical Research Communications, 页码:931-937 , 文章类型: Article,,卷期:2012年417-3]
- The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphoryladon of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53-mediated apoptosis. Because the...
- Large conductance Ca2+-activated K+ channels modulate endothelial cell outward currents and nitric oxide release in the intact rat superior mesenteric artery
[作者:Climent, B; Schubert, R; Stankevicius, E; Garcia-Sacristan, A; Simonsen, U; Rivera, L,期刊:Biochemical and Biophysical Research Communications, 页码:1007-1013 , 文章类型: Article,,卷期:2012年417-3]
- Endothelial cells (EC) control vascular smooth muscle cell (VSMC) tone by release of paracrine factors. VSMC may also influence the EC layer, and therefore, the present study hypothesized that the opening of large-conduc...
- Uridine adenosine tetraphosphate (Up(4)A) is a strong inductor of smooth muscle cell migration via activation of the P2Y(2) receptor and cross-communication to the PDGF receptor
[作者:Wiedon, A; Tolle, M; Bastine, J; Schuchardt, M; Huang, T; Jankowski, V; Jankowski, J; Zidek, W; van der Giet, M,期刊:Biochemical and Biophysical Research Communications, 页码:1035-1040 , 文章类型: Article,,卷期:2012年417-3]
- The recently discovered dinucleotide uridine adenosine tetraphosphate (Up(4)A) was found in human plasma and characterized as endothelium-derived vasoconstrictive factor (EDCF). A further study revealed a positive correl...
- Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development
[作者:Skogastierna, C; Johansson, M; Parini, P; Eriksson, M; Eriksson, LC; Ekstrom, L; Bjorkhem-Bergman, L,期刊:Biochemical and Biophysical Research Communications, 页码:1046-1051 , 文章类型: Article,,卷期:2012年417-3]
- Background: Statins have been reported to have anti-carcinogenic properties in addition to their cholesterol-lowering effects, but the mechanism is unknown. Thioredoxin reductases (TrxR) are selenium-containing enzymes o...
- Liver kinase B1 expression (LKB1) is repressed by estrogen receptor alpha (ER alpha) in MCF-7 human breast cancer cells
[作者:Linher-Melville, K; Zantinge, S; Singh, G,期刊:Biochemical and Biophysical Research Communications, 页码:1063-1068 , 文章类型: Article,,卷期:2012年417-3]
- Background: Liver kinase 1 (LKB1) is emerging as a multifunctional protein, acting as a key metabolic enzyme, regulator of cell polarity, and transcription factor. Altered LKB1 expression has been linked with various can...
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