- Antisense Knockdown of Kras Inhibits Fibrosis in a Rat Model of Unilateral Ureteric Obstruction
[作者:Wang, JH; Newbury, LJ; Knisely, AS; Monia, B; Hendry, BM; Sharpe, CC,期刊:American Journal of Pathology, 页码:82-90 , 文章类型: Article,,卷期:2012年180-1]
- Tubulointerstitial fibrosis is the hallmark of chronic kidney disease and is characterized by an increase in the number and activity of interstitial fibroblasts and by excessive matrix deposition. Ras is an intracellular...
- Renal Dendritic Cells Adopt a Pro-Inflammatory Phenotype in Obstructive Uropathy to Activate T Cells but Do Not Directly Contribute to Fibrosis
[作者:Snelgrove, SL; Kausman, JY; Lo, C; Lo, C; Ooi, JD; Coates, PT; Hickey, MJ; Holdsworth, SR; Kurts, C; Engel, DR; Kitching, AR,期刊:American Journal of Pathology, 页码:91-103 , 文章类型: Article,,卷期:2012年180-1]
- Unilateral ureteral obstruction (UUO) is a well-characterized murine model of renal inflammation leading to fibrosis. Renal dendritic cells (DCs) constitute a significant portion of kidney leukocytes and may participate ...
- Absence of Mannose-Binding Lectin Prevents Hyperglycemic Cardiovascular Complications
[作者:Pavlov, VI; La Bonte, LR; Baldwin, WM; Markiewski, MM; Lambris, JD; Stahl, GL,期刊:American Journal of Pathology, 页码:104-112 , 文章类型: Article,,卷期:2012年180-1]
- Diabetes, stress, pharmaceuticals, surgery, and physical trauma can lead to hyperglycemic conditions. A consistent relationship has been found between chronic inflammation and the cardiovascular complications of hypergly...
- A Collagen alpha 2(I) Mutation Impairs Healing after Experimental Myocardial Infarction
[作者:Hofmann, U; Bonz, A; Frantz, S; Hu, K; WalIer, C; Roemer, K; Wolf, J; Gattenlohner, S; Bauersachs, J; Ertl, G,期刊:American Journal of Pathology, 页码:113-122 , 文章类型: Article,,卷期:2012年180-1]
- Collagen breakdown and de novo synthesis are important processes during early wound healing after myocardial infarction (MI). We tested the hypothesis that collagen I, the main constituent of the extracellular matrix, af...
- Heat Shock Proteins 27 and 70 Are Potential Biliary Markers for the Detection of Cholangiocarcinoma
[作者:Sato, Y; Harada, K; Sasaki, M; Yasaka, T; Nakanuma, Y,期刊:American Journal of Pathology, 页码:123-130 , 文章类型: Article,,卷期:2012年180-1]
- Cholangiocarcinoma often is diagnosed at an advanced stage. Thus, it is necessary to establish sensitive screening methods that would allow cholangiocarcinoma and preferably its precursor lesion [biliary intraepithelial ...
- KIF20A mRNA and Its Product MKlp2 Are Increased During Hepatocyte Proliferation and Hepatocarcinogenesis
[作者:Gasnereau, I; Boissan, M; Margall-Ducos, G; Couchy, G; Wendum, D; Bourgain-Guglielmetti, F; Desdouets, C; Lacombe, ML; Zucman-Rossi, J; Sobczak-Thepot, J,期刊:American Journal of Pathology, 页码:131-140 , 文章类型: Article,,卷期:2012年180-1]
- Mitotic kinesin-like protein 2 (MKlp2), a microtubule-associated motor, is required during mitosis exit for the final step of cytokine;is. It also contributes to retrograde vesicular trafficking from the Golgi apparatus ...
- Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine
[作者:Gobbetti, T; Cenac, N; Motta, JP; Rolland, C; Martin, L; Andrade-Gordon, P; Steinhoff, M; Barocelli, E; Vergnolle, N,期刊:American Journal of Pathology, 页码:141-152 , 文章类型: Article,,卷期:2012年180-1]
- Proteases and proteinase-activated receptor (PAR) activation are involved in several intestinal inflammatory conditions. We hypothesized that serine proteases and PAR activation could also modulate the intestinal injury ...
- Oxygen Modulates the Response of First-Trimester Trophoblasts to Hyperglycemia
[作者:Frohlich, JD; Huppertz, B; Abuja, PM; Konig, J; Desoye, G,期刊:American Journal of Pathology, 页码:153-164 , 文章类型: Article,,卷期:2012年180-1]
- Pregestational diabetes retards early embryonic growth. Placental and fetal growth are closely associated, suggesting that placental growth is also impaired. During the first trimester of gestation, oxygen tension rises ...
- Blockade of Interleukin-6 Receptor Alleviates Disease in Mouse Model of Scleroderma
[作者:Kitaba, S; Murota, H; Terao, M; Azukizawa, H; Terabe, F; Shima, Y; Fujimoto, M; Tanaka, T; Naka, T; Kishimoto, T; Katayama, I,期刊:American Journal of Pathology, 页码:165-176 , 文章类型: Article,,卷期:2012年180-1]
- Activation of fibroblasts by interleukin-6 (IL-6) is implicated in the pathogenesis of scleroderma, suggesting that the inhibition of fibroblast activation may be a promising scleroderma treatment. In this study, we used...
- Expression of Aquaporin-4 Augments Cytotoxic Brain Edema after Traumatic Brain Injury during Acute Ethanol Exposure
[作者:Katada, R; Nishitani, Y; Honmou, O; Mizuo, K; Okazaki, S; Tateda, K; Watanabe, S; Matsumoto, H,期刊:American Journal of Pathology, 页码:17-23 , 文章类型: Article,,卷期:2012年180-1]
- We previously reported that ethanol consumption affects morbidity and mortality after traumatic brain injury (TBI) by accelerating brain edema via oxidative stress after TBI. Aquaporin-4 (AQP4), a water channel, is invol...
- Chlamydia trachomatis Disturbs Epithelial Tissue Homeostasis in Fallopian Tubes via Paracrine Wnt Signaling
[作者:Kessler, M; Zielecki, J; Thieck, O; Mollenkopf, HJ; Fotopoulou, C; Meyer, TF,期刊:American Journal of Pathology, 页码:186-198 , 文章类型: Article,,卷期:2012年180-1]
- The obligate intracellular pathogen Chlamydia trachomatis (Ctr) is a major cause of sexually transmitted disease and infertility worldwide. Ascending genital infections cause inflammation of fallopian tubes and subsequen...
- CCR7 with S1P(1) Signaling through AP-1 for Migration of Foxp3(+) Regulatory T-Cells Controls Autoimmune Exocrinopathy
[作者:Ishimaru, N; Yamada, A; Nitta, T; Arakaki, R; Lipp, M; Takahama, Y; Hayashi, Y,期刊:American Journal of Pathology, 页码:199-208 , 文章类型: Article,,卷期:2012年180-1]
- Forkhead box p3-positive (Foxp3(+)) regulatory T cells (T(reg) cells) participate in maintaining peripheral immune tolerance and suppressing autoimmunity. We recently reported that in situ patrolling by C-C-chemokine rec...
- TLR9 Ligand CpG-ODN Applied to the Injured Mouse Cornea Elicits Retinal Inflammation
[作者:Chinnery, HR; McLenachan, S; Binz, N; Sun, Y; Forrester, JV; Degli-Esposti, MA; Pearlman, E; McMenamin, PG,期刊:American Journal of Pathology, 页码:209-220 , 文章类型: Article,,卷期:2012年180-1]
- During bacterial and viral infections, unmethylated CpG-DNA released by proliferating and dying microbes is recognized by toll-like receptor (TLR) 9 in host cells, initiating innate immune responses. Many corneal infecti...
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