- Clinical and Biological Significance of KISS1 Expression in Prostate Cancer
[作者：Wang, HH; Jones, J; Turner, T; He, QHP; Hardy, S; Grizzle, WE; Welch, DR; Yates, C,期刊：American Journal of Pathology, 页码：1170-1178 , 文章类型： Article，,卷期：2012年180-3]
- For men in the United States, prostate cancer (PCa) is the most frequent malignancy and the second leading cause of cancer mortality. The metastatic spread of PCa is responsible for most deaths related to PCa. Although K...
- Mutant BRAF Induces DNA Strand Breaks, Activates DNA Damage Response Pathway, and Up-Regulates Glucose Transporter-1 in Nontransformed Epithelial Cells
[作者：Sheu, JJC; Guan, B; Tsai, FJ; Hsiao, EYT; Chen, CM; Seruca, R; Wang, TL; Shih, IM,期刊：American Journal of Pathology, 页码：1179-1188 , 文章类型： Article，,卷期：2012年180-3]
- Although the oncogenic functions of activating BRAF mutations have been dearly demonstrated in human cancer, their roles in nontransformed epithelial cells remain largely unclear. Investigating the cellular response to t...
- Role of ERRF, a Novel ER-Related Nuclear Factor, in the Growth Control of ER-Positive Human Breast Cancer Cells
[作者：Su, D; Fu, XY; Fan, SQ; Wu, X; Wang, XX; Fu, LY; Dong, XY; Ni, JJ; Fu, L; Zhu, ZM; Dong, JT,期刊：American Journal of Pathology, 页码：1189-1201 , 文章类型： Article，,卷期：2012年180-3]
- Whereas estrogen-estrogen receptor alpha (ER) signaling plays an important role in breast cancer growth, it is also necessary for the differentiation of normal breast epithelial cells. How this functional conversion occu...
- The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer
[作者：Scrima, M; De Marco, C; De Vita, F; Fabiani, F; Franco, R; Pirozzi, G; Rocco, G; Malanga, D; Viglietto, G,期刊：American Journal of Pathology, 页码：1202-1214 , 文章类型： Article，,卷期：2012年180-3]
- The aim of the present work was to identify protein tyrosine phosphatases (PTPs) as novel, candidate tumor suppressor genes in lung cancer. Among the 38 PTPs in the human genome that show specificity for phosphotyrosine,...
- CXCR6 and CCR5 Localize T Lymphocyte Subsets in Nasopharyngeal Carcinoma
[作者：Parsonage, G; Machado, LR; Hui, JWY; McLarnon, A; Schmaler, T; Balasothy, M; To, KF; Vlantis, AC; van Hasselt, CA; Lo, KW; Wong, WL; Hui, EP; Chan, ATC; Lee, SP,期刊：American Journal of Pathology, 页码：1215-1222 , 文章类型： Article，,卷期：2012年180-3]
- The substantial T lymphocyte infiltrate found in cases of nasopharyngeal carcinoma (NPC) has been implicated in the promotion of both tumor growth and immune escape. Conversely, because malignant NPC cells harbor the Eps...
- High Anaplastic Lymphoma Kinase Immunohistochemical Staining in Neuroblastoma and Ganglioneuroblastoma Is an Independent Predictor of Poor Outcome
[作者：Duijkers, FAM; Gaal, J; Meijerink, JPP; Admiraal, P; Pieters, R; de Krijger, RR; van Noesel, MM,期刊：American Journal of Pathology, 页码：1223-1231 , 文章类型： Article，,卷期：2012年180-3]
- Anaplastic lymphoma kinase (ALK) mutations occur in 3% to 11% of neuroblastoma (NBL) cases and are associated with high ALK levels. However, high ALK levels appear to be a mutation-independent hallmark of NBL. Evidence a...
- Plexin-B1 and Semaphorin 4D Cooperate to Promote Perineural Invasion in a RhoA/ROK-Dependent Manner
[作者：Binmadi, NO; Yang, YH; Zhou, H; Proia, P; Lin, YL; De Paula, AMB; Guimaraes, ALS; Poswar, FO; Sundararajan, D; Basile, JR,期刊：American Journal of Pathology, 页码：1232-1242 , 文章类型： Article，,卷期：2012年180-3]
- Perineural invasion (PNI) is a tropism of tumor cells for nerve bundles located in the surrounding stroma. It is a pathological feature observed in certain tumors, referred to as neurotropic malignancies, that severely l...
- VEGF-Mediated STAT3 Activation Inhibits Retinal Vascularization by Down-Regulating Local Erythropoietin Expression
[作者：Wang, HB; Byfield, G; Jiang, YC; Smith, GW; McCloskey, M; Hartnett, ME,期刊：American Journal of Pathology, 页码：1243-1253 , 文章类型： Article，,卷期：2012年180-3]
- Avascular, hypoxic retina has been postulated to be a source of angiogenic factors that cause aberrant angiogenesis and intravitreal neovascularization (IVNV) in retinopathy of prematurity. Vascular endothelial growth fa...
- Deficiency of Interleukin-1 Receptor Antagonist Promotes Spontaneous Femoral Artery Aneurysm Formation in Mice
[作者：Isoda, K; Kitagaki, M; Niida, T; Kondo, H; Matsubara, O; Kikuchi, M; Ohsuzu, F; Adachi, T,期刊：American Journal of Pathology, 页码：1254-1263 , 文章类型： Article，,卷期：2012年180-3]
- Femoral artery aneurysms (FAAs) are very rare, and their natural history is not well understood. In this study, we sought to analyze the pathogenesis of inflammatory FAAs in interleukin-1 receptor antagonist-deficient (I...
- Promotion of Lymphatic Integrity by Angiopoietin-1/Tie2 Signaling during Inflammation
[作者：Kajiya, K; Kidoya, H; Sawane, M; Matsumoto-Okazaki, Y; Yamanishi, H; Furuse, M; Takakura, N,期刊：American Journal of Pathology, 页码：1273-1282 , 文章类型： Article，,卷期：2012年180-3]
- The cutaneous lymphatic system plays a major role in tissue fluid homeostasis and inflammation of the skin. Although several lymphangiogenic factors are known to be involved in the formation of lymphatic vessels, the mol...
- Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment
[作者：Akiyama, K; Ohga, N; Hida, Y; Kawamoto, T; Sadamoto, Y; Ishikawa, S; Maishi, N; Akino, T; Kondoh, M; Matsuda, A; Inoue, N; Shindoh, M; Hide, K,期刊：American Journal of Pathology, 页码：1283-1293 , 文章类型： Article，,卷期：2012年180-3]
- Tumor endothelial cells (TECs) are therapeutic targets in anti-angiogenic therapy. Contrary to the traditional assumption, TECs can be genetically abnormal and might also acquire drug resistance. In this study, mouse TEC...
- Heterogeneity of Tumor Endothelial Cells Comparison between Tumor Endothelial Cells Isolated from High- and Low-Metastatic Tumors
[作者：Ohga, N; Ishikawa, S; Maishi, N; Akiyama, K; Hida, Y; Kawamoto, T; Sadamoto, Y; Osawa, T; Yamamoto, K; Kondoh, M; Ohmura, H; Shinohara, N; Nonomura, K; Shindoh, M; Hida, K,期刊：American Journal of Pathology, 页码：1294-1307 , 文章类型： Article，,卷期：2012年180-3]
- An important concept in tumor angiogenesis is that tumor endothelial cells (TECs) are genetically normal and homogeneous. However, we previously reported that TECs differ from normal ECs. Whether the characteristics of T...
- Regulation of Monocyte Chemoattractant Protein-1 Through Angiotensin II Type 1 Receptor in Prostate Cancer
[作者：Shirotake, S; Miyajima, A; Kosaka, T; Tanaka, N; Kikuchi, E; Mikami, S; Okada, Y; Oya, M,期刊：American Journal of Pathology, 页码：1008-1016 , 文章类型： Article，,卷期：2012年180-3]
- Monocyte chemoattractant protein-1 (MCP-1/CCL2) is reported to contribute to tumor progression and is regulated by the renin-angiotensin system in hypertensive disease. In this study, we investigated the clinical outcome...
- PTEN Regulates PDGF Ligand Switch for beta-PDGFR Signaling in Prostate Cancer
[作者：Conley-LaComb, MK; Huang, W; Wang, SH; Shi, DP; Jung, YS; Najy, A; Fridman, R; Bonfil, RD; Cher, ML; Chen, YQ; Kim, HRC,期刊：American Journal of Pathology, 页码：1017-1027 , 文章类型： Article，,卷期：2012年180-3]
- Platelet-derived growth factor (PDGF) family members are potent growth factors that regulate cell proliferation, migration, and transformation. Clinical studies have shown that both PDGF receptor beta (beta-PDGF) and its...
- Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction
[作者：Gillrie, MR; Lee, K; Gowda, DC; Davis, SP; Monestier, M; Cui, LW; Hien, TT; Day, NPJ; Ho, M,期刊：American Journal of Pathology, 页码：1028-1039 , 文章类型： Article，,卷期：2012年180-3]
- Plasmodium falciparum is a protozoan parasite of human erythrocytes that causes the most severe form of malaria. Severe P. falciparum infection is associated with endothelial activation and permeability, which are import...
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