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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent [作者：JAKOBSCHE CHARLES E; MCENANEY PATRICK J; ZHANG ANDREW X; SPIEGEL DAVID A,期刊：ACS CHEMICAL BIOLOGY, 页码：315-320 , 文章类型： Article，,卷期：2012年7-2] Synthetic compounds for controlling or creating human immunity have the potential to revolutionize disease treatment. Motivated by challenges in this arena, we report herein a strategy to target metastatic. cancer cells ... Methoxy Stilbenes as Potent, Specific, Untransported, and Noncytotoxic Inhibitors of Breast Cancer Resistance Protein [作者：VALDAMERI GLAUCIO; RANGEL LUCIANA PEREIRA; SPATAFORA CARMELA; GUITTON JEROME; GAUTHIER CHARLOTTE; ARNAUD OPHELIE; FERREIRAPEREIRA ANTONIO; FALSON PIERRE; WINNISCHOFER SHEILA M B; ROCHA MARIA E M; TRINGALI CORRADO; DI PIETRO ATTILIO,期刊：ACS CHEMICAL BIOLOGY, 页码：321-329 , 文章类型： Article，,卷期：2012年7-2] The ABCG2 multidrug transporter is known to confer cancer cell multidrug resistance by causing the efflux of anticancer drugs; therefore, selective inhibitors have the potential to improve chemotherapeutic treatments. He... A Novel Class of Small Molecule Inhibitors of HDAC6 [作者：INKS ELIZABETH S; JOSEY BENJAMIN J; JESINKEY SEAN R; CHOU C JAMES,期刊：ACS CHEMICAL BIOLOGY, 页码：330-338 , 文章类型： Article，,卷期：2012年7-2] Histone deacetylases (HDACs) are a family of enzymes that play significant roles in numerous biological processes and diseases. HDACs are best known for their repressive influence on gene transcription through histone de... Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis [作者：SANTAGATA SANDRO; XU YAMING; WIJERATNE E M KITHSIRI; KONTNIK RENEE; ROONEY CHRISTINE; PERLEY CASEY C; KWON HYOUNGTAE; CLARDY JON; KESARI SANTOSH; WHITESELL LUKE; LINDQUIST SUSAN; GUNATILAKA A A LESLIE,期刊：ACS CHEMICAL BIOLOGY, 页码：339-348 , 文章类型： Article，,卷期：2012年7-2] Unlike normal tissues, cancers experience profound alterations in protein homeostasis. Powerful innate adaptive mechanisms, especially the transcriptional response regulated by Heat Shock Factor 1 (HSF1), are activated i... Cheminformatics-Driven Discovery of Selective, Nanomolar Inhibitors for Staphylococcal Pyruvate Kinase [作者：AXERIOCILIES PETER; SEE RAYMOND H; ZORAGHI ROYA; WORRAL LIAM; LIAN TIAN; STOYNOV NIKOLAY; JIANG JIHONG; KAUR SUKHBIR; JACKSON LINDA; GONG HUANSHENG; SWAYZE RICK; ARNANDORON EMILY; KUMAR NAG S; MOREAU ANNE; HSING MICHAEL; STRYNADKA NATALIE C; MCMASTER WILLIAM R; FINAY B BRETT; FOSTER LEONARD J; YOUNG ROBERT N; REINER NEIL E; CHERKASOV ARTEM,期刊：ACS CHEMICAL BIOLOGY, 页码：349-358 , 文章类型： Article，,卷期：2012年7-2] We have recently mapped the protein interaction network of methicillin-resistant Staphylococcus aureus (MRSA), which revealed its scale-free organization with characteristic presence of highly connected hub proteins that...