- Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket
[作者:Yu, XW; Lu, L; Cai, LF; Tong, P; Tan, SY; Zou, P; Meng, FX; Chen, YH; Jiang, SB,期刊:Journal of virology, 页码:589-593 , 文章类型: Article,,卷期:2012年86-1]
- To prove that the peptidic HIV-1 fusion inhibitors containing the pocket-binding domain (PBD) mainly target the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR), we constructed pseudoviruses by replacement o...
- Reconstitution of the Kaposi's Sarcoma-Associated Herpesvirus Nuclear Egress Complex and Formation of Nuclear Membrane Vesicles by Coexpression of ORF67 and ORF69 Gene Products
[作者:Desai, PJ; Pryce, EN; Henson, BW; Luitweiler, EM; Cothran, J,期刊:Journal of virology, 页码:594-598 , 文章类型: Article,,卷期:2012年86-1]
- The Kaposi's sarcoma-associated herpesvirus nuclear egress complex is composed of two proteins, ORF67 and ORF69. In this study, we have recapitulated the KSHV complex by coexpression of these two proteins in insect cells...
- p53 Degradation Activity, Expression, and Subcellular Localization of E6 Proteins from 29 Human Papillomavirus Genotypes
[作者:Mesplede, T; Gagnon, D; Bergeron-Labrecque, F; Azar, I; Senechal, H; Coutlee, F; Archambault, J,期刊:Journal of virology, 页码:94-107 , 文章类型: Article,,卷期:2012年86-1]
- Human papillomaviruses (HPVs) are the etiological agents of cervical cancer and other human malignancies. HPVs are classified into high-and low-risk genotypes according to their association with cancer. Host cell transfo...
- Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection
[作者:Vogel, R; Seyffert, M; Strasser, R; de Oliveira, AP; Dresch, C; Glauser, DL; Jolinon, N; Salvetti, A; Weitzman, MD; Ackermann, M; Fraefel, C,期刊:Journal of virology, 页码:143-155 , 文章类型: Article,,卷期:2012年86-1]
- Adeno-associated virus type 2 (AAV2) is a human parvovirus that relies on a helper virus for efficient replication. Herpes simplex virus 1 (HSV-1) supplies helper functions and changes the environment of the cell to prom...
- A Novel Cyanophage with a Cyanobacterial Nonbleaching Protein A Gene in the Genome
[作者:Gao, EB; Gui, JF; Zhang, QY,期刊:Journal of virology, 页码:236-245 , 文章类型: Article,,卷期:2012年86-1]
- A cyanophage, PaV-LD, has been isolated from harmful filamentous cyanobacterium Planktothrix agardhii in Lake Donghu, a shallow freshwater lake in China. Here, we present the cyanophage's genomic organization and major s...
- A Novel Self-Replicating Chimeric Lentivirus-Like Particle
[作者:Jurgens, CK; Young, KR; Madden, VJ; Johnson, PR; Johnston, RE,期刊:Journal of virology, 页码:246-261 , 文章类型: Article,,卷期:2012年86-1]
- Successful live attenuated vaccines mimic natural exposure to pathogens without causing disease and have been successful against several viruses. However, safety concerns prevent the development of attenuated human immun...
- The Activity Spectrum of Vif from Multiple HIV-1 Subtypes against APOBEC3G, APOBEC3F, and APOBEC3H
[作者:Binka, M; Ooms, M; Steward, M; Simon, V,期刊:Journal of virology, 页码:49-59 , 文章类型: Article,,卷期:2012年86-1]
- The APOBEC3 family comprises seven cytidine deaminases (APOBEC3A [A3A] to A3H), which are expressed to various degrees in HIV-1 susceptible cells. The HIV-1 Vif protein counteracts APOBEC3 restriction by mediating its de...
- Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma
[作者:Sivachandran, N; Dawson, CW; Young, LS; Liu, FF; Middeldorp, J; Frappier, L,期刊:Journal of virology, 页码:60-68 , 文章类型: Article,,卷期:2012年86-1]
- Approximately 10% of gastric carcinomas (GC) are comprised of cells latently infected with Epstein-Barr virus (EBV); however, the mechanism by which EBV contributes to the development of this malignancy is unclear. We ha...
- Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals
[作者:Contreras-Galindo, R; Kaplan, MH; Contreras-Galindo, AC; Gonzalez-Hernandez, MJ; Ferlenghi, I; Giusti, F; Lorenzo, E; Gitlin, SD; Dosik, MH; Yamamura, Y; Markovitz, DM,期刊:Journal of virology, 页码:262-276 , 文章类型: Article,,卷期:2012年86-1]
- We previously reported finding the RNA of a type K human endogenous retrovirus, HERV-K (HML-2), at high titers in the plasma of HIV-1-infected and cancer patients (R. Contreras-Galindo et al., J. Virol. 82: 9329-9236, 20...
- HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome
[作者:Ranasinghe, S; Flanders, M; Cutler, S; Soghoian, DZ; Ghebremichael, M; Davis, I; Lindqvist, M; Pereyra, F; Walker, BD; Heckerman, D; Streeck, H,期刊:Journal of virology, 页码:277-283 , 文章类型: Article,,卷期:2012年86-1]
- A successful prophylactic vaccine is characterized by long-lived immunity, which is critically dependent on CD4 T cell-mediated helper signals. Indeed, most licensed vaccines induce antigen-specific CD4 T cell responses,...
- Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate
[作者:Hansman, GS; Shahzad-ul-Hussan, S; McLellan, JS; Chuang, GY; Georgiev, I; Shimoike, T; Katayama, K; Bewley, CA; Kwong, PD,期刊:Journal of virology, 页码:284-292 , 文章类型: Article,,卷期:2012年86-1]
- Human noroviruses bind with their capsid-protruding domains to histo-blood-group antigens (HBGAs), an interaction thought to direct their entry into cells. Although human noroviruses are the major cause of gastroenteriti...
- Fatal Pancreatitis in Simian Immunodeficiency Virus SIV(mac251)-Infected Macaques Treated with 2 ',3 '-Dideoxyinosine and Stavudine following Cytotoxic-T-Lymphocyte-Associated Antigen 4 and Indoleamine 2,3-Dioxygenase Blockade
[作者:Vaccari, M; Boasso, A; Fenizia, C; Fuchs, D; Hryniewicz, A; Morgan, T; Weiss, D; Doster, MN; Heraud, JM; Shearer, GM; Franchini, G,期刊:Journal of virology, 页码:108-113 , 文章类型: Article,,卷期:2012年86-1]
- Human immunodeficiency virus (HIV) infection is associated with immune activation, CD4(+)-T-cell loss, and a progressive decline of immune functions. Antiretroviral therapy (ART) only partially reverses HIV-associated im...
- Defining the Roles of cis-Acting RNA Elements in Tombusvirus Replicase Assembly In Vitro
[作者:Pathak, KB; Pogany, J; Xu, K; White, KA; Nagy, PD,期刊:Journal of virology, 页码:156-171 , 文章类型: Article,,卷期:2012年86-1]
- In addition to its central role as a template for replication and translation, the viral plus-strand RNA genome also has nontemplate functions, such as recruitment to the site of replication and assembly of the viral rep...
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