- Structural Basis for the Substrate Specificity of a Novel beta-N-Acetylhexosaminidase StrH Protein from Streptococcus pneumoniae R6
[作者:Jiang, YL; Yu, WL; Zhang, JW; Frolet, C; Di Guilmi, AM; Zhou, CZ; Vernet, T; Chen, YX,期刊:Journal of Biological Chemistry, 页码:43004-43012 , 文章类型: Article,,卷期:2011年286-50]
- The beta-N-acetylhexosaminidase (EC 3.2.1.52) from glycoside hydrolase family 20 (GH20) catalyzes the hydrolysis of the beta-N-acetylglucosamine (NAG) group from the nonreducing end of various glycoconjugates. The putati...
- Complex Regulation of p73 Isoforms after Alteration of Amyloid Precursor Polypeptide (APP) Function and DNA Damage in Neurons
[作者:Benosman, S; Meng, XJ; Von Grabowiecki, Y; Palamiuc, L; Hritcu, L; Gross, I; Mellitzer, G; Taya, Y; Loeffler, JP; Gaiddon, C,期刊:Journal of Biological Chemistry, 页码:43013-43025 , 文章类型: Article,,卷期:2011年286-50]
- Background: Alterations of the APP pathway or DNA damage induce neuronal cell death. Results: Alterations of the APP pathway or DNA damage increase TAp73 expression and reduce Delta Np73 protein levels. Conclusion: A tig...
- Engineering Bifunctional Laccase-Xylanase Chimeras for Improved Catalytic Performance
[作者:Ribeiro, LF; Furtado, GP; Lourenzoni, MR; Costa, AJ; Santos, CR; Nogueira, SCP; Betini, JA; Polizeli, MDTM; Murakami, MT; Ward, RJ,期刊:Journal of Biological Chemistry, 页码:43026-43038 , 文章类型: Article,,卷期:2011年286-50]
- Background: Rational design methods can be used to create chimeric enzymes with novel catalytic combinations. Results: Bifunctional enzymes combining xylanase and laccase activities showed enhanced catalytic activity and...
- Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif
[作者:Llanos, S; Royer, C; Lu, M; Bergamaschi, D; Lee, WH; Lu, X,期刊:Journal of Biological Chemistry, 页码:43039-43044 , 文章类型: Article,,卷期:2011年286-50]
- Background: Regulatory subunits confer substrate specificity to protein phosphatases. Results: iASPP, unlike ASPP2, interacts with protein phosphatase 1 (PP1) via a noncanonical binding motif within its SH3 domain. Concl...
- The Composition of Plant Mitochondrial Supercomplexes Changes with Oxygen Availability
[作者:Ramirez-Aguilar, SJ; Keuthe, M; Rocha, M; Fedyaev, VV; Kramp, K; Gupta, KJ; Rasmusson, AG; Schulze, WX; van Dongen, JT,期刊:Journal of Biological Chemistry, 页码:43045-43053 , 文章类型: Article,,卷期:2011年286-50]
- Background: Respiratory supercomplexes are known to exist, but their function remains to be revealed. Results: Plant supercomplexes are affected by hypoxia and a concomitant drop in pH. Conclusion: Respiratory supercompl...
- Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein
[作者:Du, F; Hui, Y; Zhang, M; Linton, MF; Fazio, S; Fan, DP,期刊:Journal of Biological Chemistry, 页码:43054-43061 , 文章类型: Article,,卷期:2011年286-50]
- PCSK9 (proprotein convertase subtilisin/kexin type 9) has emerged as a novel therapeutic target for hypercholesterolemia due to its LDL receptor (LDLR)-reducing activity. Although its structure has been solved, the lack ...
- Gastric Inhibitory Peptide Controls Adipose Insulin Sensitivity via Activation of cAMP-response Element-binding Protein and p110 beta Isoform of Phosphatidylinositol 3-Kinase
[作者:Mohammad, S; Ramos, LS; Buck, J; Levin, LR; Rubino, F; McGraw, TE,期刊:Journal of Biological Chemistry, 页码:43062-43070 , 文章类型: Article,,卷期:2011年286-50]
- Gastric inhibitory peptide (GIP) is an incretin hormone secreted in response to food intake. The best known function of GIP is to enhance glucose-dependent insulin secretion from pancreatic beta-cells. Extra-pancreatic e...
- FKBP38 Peptidylprolyl Isomerase Promotes the Folding of Cystic Fibrosis Transmembrane Conductance Regulator in the Endoplasmic Reticulum
[作者:Banasavadi-Siddegowda, YK; Mai, JB; Fan, YF; Bhattacharya, S; Giovannucci, DR; Sanchez, ER; Fischer, G; Wang, XD,期刊:Journal of Biological Chemistry, 页码:43071-43080 , 文章类型: Article,,卷期:2011年286-50]
- FK506-binding protein 38 (FKBP38), a membrane-anchored, tetratricopeptide repeat (TPR)-containing immunophilin, associates with nascent plasma membrane ion channels in the endoplasmic reticulum (ER). It promotes the matu...
- Ceramide Kinase Regulates the Production of Tumor Necrosis Factor alpha (TNF alpha) via Inhibition of TNF alpha-converting Enzyme
[作者:Lamour, NF; Wijesinghe, DS; Mietla, JA; Ward, KE; Stahelin, RV; Chalfant, CE,期刊:Journal of Biological Chemistry, 页码:42808-42817 , 文章类型: Article,,卷期:2011年286-50]
- Background: Pro-TNF alpha is transformed into the active/soluble form through proteolysis by TNF alpha-converting enzyme (TACE). Results: Genetic ablation of ceramide kinase induces an increase in TACE activity and secre...
- Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism
[作者:Dange, T; Smith, D; Noy, T; Rommel, PC; Jurzitza, L; Cordero, RJB; Legendre, A; Finley, D; Goldberg, AL; Schmidt, M,期刊:Journal of Biological Chemistry, 页码:42830-42839 , 文章类型: Article,,卷期:2011年286-50]
- Background: Association of the proteasome core with activators regulates proteasome activity. Results: Blm10 association increases proteasome activity toward peptides and the unstructured proteasome substrate tau-441. Th...
- Enhanced Activity of Transforming Growth Factor beta 1 (TGF-beta 1) Bound to Cartilage Oligomeric Matrix Protein
[作者:Haudenschild, DR; Hong, E; Yik, JHN; Chromy, B; Morgelin, M; Snow, KD; Acharya, C; Takada, Y; Di Cesare, PE,期刊:Journal of Biological Chemistry, 页码:43250-43258 , 文章类型: Article,,卷期:2011年286-50]
- Cartilage oligomeric matrix protein (COMP) is an important non-collagenous cartilage protein that is essential for the structural integrity of the cartilage extracellular matrix. The repeated modular structure of COMP al...
- Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity
[作者:Jeong, BR; Lin, Y; Joe, A; Guo, M; Korneli, C; Yang, HR; Wang, P; Yu, M; Cerny, RL; Staiger, D; Alfano, JR; Xu, YH,期刊:Journal of Biological Chemistry, 页码:43272-43281 , 文章类型: Article,,卷期:2011年286-50]
- The Pseudomonas syringae type III effector HopU1 is a mono-ADP-ribosyltransferase that is injected into plant cells by the type III protein secretion system. Inside the plant cell it suppresses immunity by modifying RNA-...
- Helix 8 Plays a Crucial Role in Bradykinin B(2) Receptor Trafficking and Signaling
[作者:Feierler, J; Wirth, M; Welte, B; Schussler, S; Jochum, M; Faussner, A,期刊:Journal of Biological Chemistry, 页码:43282-43293 , 文章类型: Article,,卷期:2011年286-50]
- Upon activation the human bradykinin B(2) receptor (B(2)R) acts as guanine nucleotide exchange factor for the G proteins G(q/11) and G(i). Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) a...
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