- RB1CC1 Protein Suppresses Type II Collagen Synthesis in Chondrocytes and Causes Dwarfism
[作者:Nishimura, I; Chano, T; Kita, H; Matsusue, Y; Okabe, H,期刊:Journal of Biological Chemistry, 页码:43925-43932 , 文章类型: Article,,卷期:2011年286-51]
- RB1-inducible coiled-coil 1 (RB1CC1) functions in various processes, such as cell growth, differentiation, senescence, apoptosis, and autophagy. The conditional transgenic mice with cartilage-specific RB1CC1 excess that ...
- The Thiazide-sensitive NaCl Cotransporter Is Targeted for Chaperone-dependent Endoplasmic Reticulum-associated Degradation
[作者:Needham, PG; Mikoluk, K; Dhakarwal, P; Khadem, S; Snyder, AC; Subramanya, AR; Brodsky, JL,期刊:Journal of Biological Chemistry, 页码:43611-43621 , 文章类型: Article,,卷期:2011年286-51]
- The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) mediates salt reabsorption in the distal nephron of the kidney and is the target of thiazide diuretics, which are commonly prescribed to treat hypertension. Mutati...
- Human Lipooligosaccharide IGG That Prevents Endemic Meningococcal Disease Recognizes an Internal Lacto-N-neotetraose Structure
[作者:Cheng, H; Yang, ZJ; Estabrook, MM; John, CM; Jarvis, GA; McLaughlin, S; Griffiss, JM,期刊:Journal of Biological Chemistry, 页码:43622-43633 , 文章类型: Article,,卷期:2011年286-51]
- Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter the bloodstream from the oropharynx protect against disseminated disease. Human IgGs that bind the neisserial L7 lipooligosacch...
- Phospholipase C gamma 2 (PLC gamma 2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses
[作者:Gorjestani, S; Yu, M; Tang, B; Zhang, DK; Wang, DM; Lin, X,期刊:Journal of Biological Chemistry, 页码:43651-43659 , 文章类型: Article,,卷期:2011年286-51]
- C-type lectin receptors (CLRs) such as Dectin-2 function as pattern recognition receptors to sense fungal infection. However, the signaling pathways induced by these receptors remain largely unknown. Previous studies sug...
- Ubiquitin Ligase Ufd2 Is Required for Efficient Degradation of Mps1 Kinase
[作者:Liu, C; van Dyk, D; Choe, V; Yan, J; Majumder, S; Costanzo, M; Bao, X; Boone, C; Huo, K; Winey, M; Fisk, H; Andrews, B; Rao, H,期刊:Journal of Biological Chemistry, 页码:43660-43667 , 文章类型: Article,,卷期:2011年286-51]
- Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of th...
- Pathway Profiling in Mycobacterium tuberculosis ELUCIDATION OF CHOLESTEROL-DERIVED CATABOLITE AND ENZYMES THAT CATALYZE ITS METABOLISM
[作者:Thomas, ST; VanderVen, BC; Sherman, DR; Russell, DG; Sampson, NS,期刊:Journal of Biological Chemistry, 页码:43668-43678 , 文章类型: Article,,卷期:2011年286-51]
- Mycobacterium tuberculosis, the bacterium that causes tuberculosis, imports and metabolizes host cholesterol during infection. This ability is important in the chronic phase of infection. Here we investigate the role of ...
- Early Contacts between Substrate Proteins and TatA Translocase Component in Twin-arginine Translocation
[作者:Frobel, J; Rose, P; Muller, M,期刊:Journal of Biological Chemistry, 页码:43679-43689 , 文章类型: Article,,卷期:2011年286-51]
- Twin-arginine translocation (Tat) is a unique protein transport pathway in bacteria, archaea, and plastids. It mediates the transmembrane transport of fully folded proteins, which harbor a consensus twin-arginine motif i...
- The MicroRNA 15a/16-1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells IMPLICATIONS FOR APOPTOSIS REGULATION
[作者:Sambri, I; Capasso, R; Pucci, P; Perna, AF; Ingrosso, D,期刊:Journal of Biological Chemistry, 页码:43690-43700 , 文章类型: Article,,卷期:2011年286-51]
- Asparaginyl deamidation, a spontaneous protein post-bio-synthetic modification, determines isoaspartyl formation and structure-function impairment. The isoaspartyl protein carbox-yl-O-methyltransferase (PCMT1; EC 2.1.1.7...
- Mimivirus Collagen Is Modified by Bifunctional Lysyl Hydroxylase and Glycosyltransferase Enzyme
[作者:Luther, KB; Hulsmeier, AJ; Schegg, B; Deuber, SA; Raoult, D; Hennet, T,期刊:Journal of Biological Chemistry, 页码:43701-43709 , 文章类型: Article,,卷期:2011年286-51]
- Collagens, the most abundant proteins in animals, are modified by hydroxylation of proline and lysine residues and by glycosylation of hydroxylysine. Dedicated prolyl hydroxylase, lysyl hydroxylase, and collagen glycosyl...
- Junctophilin 1 and 2 Proteins Interact with the L-type Ca(2+) Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle
[作者:Golini, L; Chouabe, C; Berthier, C; Cusimano, V; Fornaro, M; Bonvallet, R; Formoso, L; Giacomello, E; Jacquemond, V; Sorrentino, V,期刊:Journal of Biological Chemistry, 页码:43717-43725 , 文章类型: Article,,卷期:2011年286-51]
- Junctophilins (JPs) anchor the endo/sarcoplasmic reticulum to the plasma membrane, thus contributing to the assembly of junctional membrane complexes in striated muscles and neurons. Recent studies have shown that JPs ma...
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