- Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis
[作者：van Rooyen, DM; Larter, CZ; Haigh, WG; Yeh, MM; Ioannou, G; Kuver, R; Lee, SP; Teoh, NC; Farrell, GC,期刊：Gastroenterology, 页码：1393-U850 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Type 2 diabetes and nonalcoholic steatohepatitis (NASH) are associated with insulin resistance and disordered cholesterol homeostasis. We investigated the basis for hepatic cholesterol accumulation wit...
- Hepatic Overexpression of Abcb11 Promotes Hypercholesterolemia and Obesity in Mice
[作者：Henkel, AS; Kavesh, MH; Kriss, MS; Dewey, AM; Rinella, ME; Green, RM,期刊：Gastroenterology, 页码：1404-U860 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: ABCB11 is a canalicular transport protein that controls the rate-limiting step in hepatic bile acid secretion. Its expression levels vary in humans, and it is not clear how these variations affect lipi...
- Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation
[作者：Fung, J; Cheung, C; Chan, SC; Yuen, MF; Chok, KSH; Sharr, W; Dai, WC; Chan, ACY; Cheung, TT; Tsang, S; Lam, B; Lai, CL; Lo, CM,期刊：Gastroenterology, 页码：1212-1219 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: We investigated the efficacy of entecavir, a cyclopentyl guanosine nucleoside analogue, as monoprophylaxis in patients with chronic hepatitis B who received a liver transplant. METHODS: We studied data...
- Host Response to Translocated Microbial Products Predicts Outcomes of Patients With HBV or HCV Infection
[作者：Sandler, NG; Koh, C; Roque, A; Eccleston, JL; Siegel, RB; Demino, M; Kleiner, DE; Deeks, SG; Liang, TJ; Heller, T; Douek, DC,期刊：Gastroenterology, 页码：1220-U640 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Chronic infection with hepatitis B or C virus (HBV or HCV) is a leading cause of cirrhosis by unknown mechanisms of pathogenesis. Translocation of gut microbial products into the systemic circulation m...
- Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21
[作者：Huang, YH; Tong, SP; Tai, AW; Hussain, M; Lok, ASF,期刊：Gastroenterology, 页码：1412-U875 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Clinical studies have associated hepatitis B virus core promoter (CP) mutations with an increased risk of hepatocellular carcinoma. The CP region overlaps with the HBV X (HBx) gene, which has been impl...
- Inhibitory Molecules That Regulate Expansion and Restoration of HCV-Specific CD4(+) T Cells in Patients With Chronic Infection
[作者：Raziorrouh, B; Ulsenheimer, A; Schraut, W; Heeg, M; Kurktschiev, P; Zachoval, R; Jung, MC; Thimme, R; Neumann-Haefelin, C; Horster, S; Wachtler, M; Spannagl, M; Haas, J; Diepolder, HM; Gruner, NH,期刊：Gastroenterology, 页码：1422-U891 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Inhibitory receptors such as programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen (CTLA)-4 mediate CD8(+) T-cell exhaustion during chronic viral infection, but little is known about ...
- Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells
[作者：Carpentier, R; Suner, RE; van Hul, N; Kopp, JL; Beaudry, JB; Cordi, S; Antoniou, A; Raynaud, P; Lepreux, S; Jacquemin, P; Leclercq, IA; Sander, M; Lemaigre, FP,期刊：Gastroenterology, 页码：1432-U902 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND& AIMS: Embryonic biliary precursor cells form a periportal sheet called the ductal plate, which is progressively remodeled to generate intrahepatic bile ducts. A limited number of ductal plate cells participat...
- Early Changes in Natural Killer Cell Function Indicate Virologic Response to Interferon Therapy for Hepatitis C
[作者：Ahlenstiel, G; Edlich, B; Hogdal, LJ; Rotman, Y; Noureddin, M; Feld, JJ; Holz, LE; Titerence, RH; Liang, TJ; Rehermann, B,期刊：Gastroenterology, 页码：1231-U651 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural k...
- Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma
[作者：Chen, CF; Lee, WC; Yang, HI; Chang, HC; Jen, CL; Iloeje, UH; Su, J; Hsiao, CHK; Wang, LY; You, SL; Lu, SN; Chen, CJ,期刊：Gastroenterology, 页码：1240-U662 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: It is not clear whether risk for hepatocellular carcinoma can be accurately determined from long-term changes in serum levels of hepatitis B virus (HBV) DNA or alanine aminotransferase (ALT). METHODS: ...
- Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States
[作者：Charlton, MR; Burns, JM; Pedersen, RA; Watt, KD; Heimbach, JK; Dierkhising, RA,期刊：Gastroenterology, 页码：1249-1253 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: The relative frequency of nonalcoholic steatohepatitis (NASH) as an indication for liver transplantation and comparative outcomes following transplantation are poorly understood. METHODS: We analyzed t...
- RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage
[作者：McClendon, AK; Dean, JL; Ertel, A; Fu, ZY; Rivadeneira, DB; Reed, CA; Bourgo, RJ; Witkiewicz, A; Addya, S; Mayhew, CN; Grimes, HL; Fortina, P; Knudsen, ES,期刊：Gastroenterology, 页码：1439-1450 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: The tumor suppressors retinoblastoma (RB) and p53 are important regulators of the cell cycle. Although human cancer cells inactivate RB and p53 by many mechanisms, the cooperative roles of these protei...
- Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice
[作者：Criscimanna, A; Speicher, JA; Houshmand, G; Shiota, C; Prasadan, K; Ji, BA; Logsdon, CD; Gittes, GK; Esni, F,期刊：Gastroenterology, 页码：1451-U447 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as wel...
- Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4-NF-kappa B-Mediated Inflammatory Response in Mice
[作者：Fiorotto, R; Scirpo, R; Trauner, M; Fabris, L; Hoque, R; Spirli, C; Strazzabosco, M,期刊：Gastroenterology, 页码：1498-U519 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in the biliary epithelium reduces bile flow and alkalinization in patients with cystic fibrosis (CF). Liver damage is ...
- A Conservative and Minimally Invasive Approach to Necrotizing Pancreatitis Improves Outcome
[作者：van Santvoort, HC; Bakker, OJ; Bollen, TL; Besselink, MG; Ali, UA; Schrijver, AM; Boermeester, MA; van Goor, H; Dejong, CH; van Eijck, CH; van Ramshorst, B; Schaapherder, AF; van der Harst, E; Hofker, S; Nieuwenhuijs, VB; Brink, MA; Kruyt, PM; Manusama, ER; van der Schelling, GP; Karsten, T; Hesselink, EJ; van Laarhoven, CJ; Rosman, C; Bosscha, K; de Wit, RJ; Houdijk, AP; Cuesta, MA; Wahab, PJ; Gooszen, HG,期刊：Gastroenterology, 页码：1254-1263 , 文章类型： Article，,卷期：2011年141-4]
- BACKGROUND & AIMS: Treatment of patients with necrotizing pancreatitis has become more conservative and less invasive, but there are few data from prospective studies to support the efficacy of this change. We performed ...
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