- Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14(+) Macrophages
[作者：Atreya, R; Zimmer, M; Bartsch, B; Waldner, MJ; Atreya, I; Neumann, H; Hildner, K; Hoffman, A; Kiesslich, R; Rink, AD; Rau, TT; Rose-John, S; Kessler, H; Schmidt, J; Neurath, MF,期刊：Gastroenterology, 页码：2026-2038 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: The anti-tumor necrosis factor (TNF) antibodies infliximab, adalimumab, and certolizumab pegol have proven clinical efficacy in Crohn's disease. Here, we assessed the effects of anti-TNF antibodies on ...
- Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer
[作者：Coissieux, MM; Tomsic, J; Castets, M; Hampel, H; Tuupanen, S; Andrieu, N; Comeras, I; Drouet, Y; Lasset, C; Liyanarachchi, S; Mazelin, L; Puisieux, A; Saurin, JC; Scoazec, JY; Wang, Q; Aaltonen, L; Tanner, SM; de la Chapelle, A; Bernet, A; Mehlen, P,期刊：Gastroenterology, 页码：2039-2046 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Expression of the netrin-1 dependence receptor UNC5C is reduced in many colorectal tumors; mice with the UNC5C mutations have increased progression of intestinal tumors. We investigated whether specifi...
- Efficacy of the Protease Inhibitor BI 201335, Polymerase Inhibitor BI 207127, and Ribavirin in Patients With Chronic HCV Infection
[作者：Zeuzem, S; Asselah, T; Angus, P; Zarski, JP; Larrey, D; Mullhaupt, B; Gane, E; Schuchmann, M; Lohse, A; Pol, S; Bronowicki, JP; Roberts, S; Arasteh, K; Zoulim, F; Heim, M; Stern, JO; Kukolj, G; Nehmiz, G; Haefner, C; Boecher, WO,期刊：Gastroenterology, 页码：2047-2055 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Therapeutic regimens are being developed for patients with hepatitis C virus (HCV) infection that do not include the combination of peginterferon alfa and ribavirin. We investigated the antiviral effec...
- Secondary, Somatic Mutations Might Promote Cyst Formation in Patients With Autosomal Dominant Polycystic Liver Disease
[作者：Janssen, MJ; Waanders, E; Morsche, RHMT; Xing, RY; Dijkman, HBPM; Woudenberg, J; Drenth, JPH,期刊：Gastroenterology, 页码：2056-U180 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Heterozygous germline mutations in PRKCSH cause autosomal dominant polycystic liver disease (PCLD), but it is not clear how they lead to cyst formation. We investigated whether mutations in cyst epithe...
- HER2 Interacts With CD44 to Up-regulate CXCR4 via Epigenetic Silencing of microRNA-139 in Gastric Cancer Cells
[作者：Bao, W; Fu, HJ; Xie, QS; Wang, L; Zhang, R; Guo, ZY; Zhao, J; Meng, YL; Ren, XL; Wang, T; Li, Q; Jin, BQ; Yao, LB; Wang, RA; Fan, DM; Chen, SY; Jia, LT; Yang, AG,期刊：Gastroenterology, 页码：2076-U210 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Human epidermal growth factor receptor 2 (HER2) (neu/ERBB2) is overexpressed on many types of cancer cells, including gastric cancer cells; HER2 overexpression has been associated with metastasis and p...
- Activity of Protease-Activated Receptors in the Human Submucous Plexus
[作者：Mueller, K; Michel, K; Krueger, D; Demir, IE; Ceyhan, GO; Zeller, F; Kreis, ME; Schemann, M,期刊：Gastroenterology, 页码：2088-U221 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Protease-activated receptors PARs) are expressed in the enteric nervous system. Excessive release of proteases has been reported in functional and inflammatory bowel diseases. Studies in several animal...
- Brain-Gut Interactions Increase Peripheral Nociceptive Signaling in Mice With Postinfectious Irritable Bowel Syndrome
[作者：Ibeakanma, C; Ochoa-Cortes, F; Miranda-Morales, M; Mcdonald, T; Spreadbury, I; Cenac, N; Cattaruzza, F; Hurlbut, D; Vanner, S; Bunnett, N; Vergnolle, N; Vanner, S,期刊：Gastroenterology, 页码：2098-U237 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: To investigate the peripheral sensory effects of repeated stress in patients with post-infectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis incr...
- Gut-Tropic T Cells That Express Integrin alpha 4 beta 7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice
[作者：Cassani, B; Villablanca, EJ; Quintana, FJ; Love, PE; Lacy-Hulbert, A; Blaner, WS; Sparwasser, T; Snapper, SB; Weiner, HL; Mora, JR,期刊：Gastroenterology, 页码：2109-2118 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Induction of oral immune tolerance (OT) blocks proinflammatory responses to orally administered antigens and might be used to treat autoimmune conditions. We investigated whether gut-tropic T cells tha...
- Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice-A Pathway Associated With Ulcerative Colitis
[作者：Kawashima, R; Kawamura, YI; Oshio, T; Son, A; Yamazaki, M; Hagiwara, T; Okada, T; Inagaki-Ohara, K; Wu, P; Szak, S; Kawamura, YJ; Konishi, F; Miyake, O; Yano, H; Saito, Y; Burkly, LC; Dohi, T,期刊：Gastroenterology, 页码：2119-U266 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: TWEAK, a member of the tumor necrosis factor (TNF) superfamily, promotes intestinal epithelial cell injury and signals through the receptor Fn14 following irradiation-induced tissue damage and during d...
- Luminal CD4(+) T Cells Penetrate Gut Epithelial Monolayers and Egress From Lamina Propria to Blood Circulation
[作者：Nemoto, Y; Kanai, T; Shinohara, T; Ito, T; Nakamura, T; Okamoto, R; Tsuchiya, K; Lipp, M; Eishi, Y; Watanabe, M,期刊：Gastroenterology, 页码：2130-U287 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: The egress of memory T cells from peripheral tissues, such as lung and skin, into the draining lymph nodes requires their expression of CC chemokine receptor 7 (CCR7). In the intestine, resident memory...
- Claudin-1 Up-regulates the Repressor ZEB-1 to Inhibit E-Cadherin Expression in Colon Cancer Cells
[作者：Singh, AB; Sharma, A; Smith, JJ; Krishnan, M; Chen, X; Eschrich, S; Washington, MK; Yeatman, TJ; Beauchamp, RD; Dhawan, P,期刊：Gastroenterology, 页码：2140-2153 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Expression of the tight junction protein claudin-1 is dysregulated in colon tumors and associates with their progression. Up-regulation of claudin-1 reduces expression of E-cadherin. We investigated th...
- Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer
[作者：Eyking, A; Ey, B; Runzl, M; Roig, AI; Reis, H; Schmid, KW; Gerken, G; Podolsky, DK; Cario, E,期刊：Gastroenterology, 页码：2154-2165 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: The Toll-like receptor (TLR) 4 mediates homeostasis of the intestinal epithelial cell (IEC) barrier. We investigated the effects of TLR4-D299G on IEC functions. METHODS: We engineered IECs (Caco-2) to ...
- Loss of Glucagon-Like Peptide-2-Induced Proliferation Following Intestinal Epithelial Insulin-Like Growth Factor-1-Receptor Deletion
[作者：Rowland, KJ; Trivedi, S; Lee, D; Wan, K; Kulkarni, RN; Holzenberger, M; Brubaker, PL,期刊：Gastroenterology, 页码：2166-U330 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Glucagon-like peptide-2 (GLP-2) is an intestinal hormone that promotes growth of the gastrointestinal tract. Although insulin-like growth factor (IGF)-1 and the IGF-1 receptor (IGF-1R) are required for...
- Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury
[作者：Liedtke, C; Bangen, JM; Freimuth, J; Beraza, N; Lambertz, D; Cubero, FJ; Hatting, M; Karlmark, KR; Streetz, KL; Krombach, GA; Tacke, F; Gassler, N; Riethmacher, D; Trautwein, C,期刊：Gastroenterology, 页码：2176-2187 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: Disruption of the nuclear factor-kappa B (NF-kappa B) essential modulator (NEMO) in hepatocytes of mice (NEMO(Delta hepa) mice) results in spontaneous liver apoptosis and chronic liver disease involvin...
- Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice
[作者：Wang, JH; Ahn, S; Fischer, TD; Byeon, JI; Dunn, WA; Behrns, KE; Leeuwenburgh, C; Kim, JS,期刊：Gastroenterology, 页码：2188-U360 , 文章类型： Article，,卷期：2011年141-6]
- BACKGROUND & AIMS: As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity foll...
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