- H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ER alpha ligand dependency
[作者：Svotelis, A; Bianco, S; Madore, J; Huppe, G; Nordell-Markovits, A; Mes-Masson, AM; Gevry, N,期刊：EMBO journal, 页码：3947-3961 , 文章类型： Article，,卷期：2011年30-19]
- Chromatin represents a repressive barrier to the process of ligand-dependent transcriptional activity of nuclear receptors. Here, we show that H3K27 methylation imposes ligand-dependent regulation of the oestrogen recept...
- RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
[作者：Levantini, E; Lee, S; Radomska, HS; Hetherington, CJ; Alberich-Jorda, M; Amabile, G; Zhang, P; Gonzalez, DA; Zhang, JY; Basseres, DS; Wilson, NK; Koschmieder, S; Huang, G; Zhang, DE; Ebralidze, AK; Bonifer, C; Okuno, Y; Gottgens, B; Tenen, DG,期刊：EMBO journal, 页码：4059-4070 , 文章类型： Article，,卷期：2011年30-19]
- The transcription factor RUNX1 is essential to establish the haematopoietic gene expression programme; however, the mechanism of how it activates transcription of haematopoietic stem cell (HSC) genes is still elusive. He...
- A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories
[作者：Agis-Balboa, RC; Arcos-Diaz, D; Wittnam, J; Govindarajan, N; Blom, K; Burkhardt, S; Haladyniak, U; Agbemenyah, HY; Zovoilis, A; Salinas-Riester, G; Opitz, L; Sananbenesi, F; Fischer, A,期刊：EMBO journal, 页码：4071-4083 , 文章类型： Article，,卷期：2011年30-19]
- Extinction learning refers to the phenomenon that a previously learned response to an environmental stimulus, for example, the expression of an aversive behaviour upon exposure to a specific context, is reduced when the ...
- Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas
[作者：LeFave, CV; Squatrito, M; Vorlova, S; Rocco, GL; Brennan, CW; Holland, EC; Pan, YX; Cartegni, L,期刊：EMBO journal, 页码：4084-4097 , 文章类型： Article，,卷期：2011年30-19]
- In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor pro...
- A pH-regulated dimeric bouquet in the structure of von Willebrand factor
[作者：Zhou, YF; Eng, ET; Nishida, N; Lu, CF; Walz, T; Springer, TA,期刊：EMBO journal, 页码：4098-4111 , 文章类型： Article，,卷期：2011年30-19]
- At the acidic pH of the trans-Golgi and Weibel-Palade bodies (WPBs), but not at the alkaline pH of secretion, the C-terminal similar to 1350 residues of von Willebrand factor (VWF) zip up into an elongated, dimeric bouqu...
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