- Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
[作者:Kruit, JK; Wijesekara, N; Fox, JEM; Dai, XQ; Brunham, LR; Searle, GJ; Morgan, GP; Costin, AJ; Tang, RM; Bhattacharjee, A; Johnson, JD; Light, PE; Marsh, BJ; MacDonald, PE; Verchere, CB; Hayden, MR,期刊:Diabetes, 页码:3186-3196 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from beta-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in isle...
- Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
[作者:Wu, JX; Zhang, F; Yan, MH; Wu, DM; Yu, QJ; Zhang, Y; Zhou, B; McBurney, MW; Zhai, QW,期刊:Diabetes, 页码:3197-3207 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Wld(S) (Wallerian degeneration slow), a fusion protein from a spontaneous mutation containing full-length nicotinamide mononucleotide adenylyltransferase 1, has NAD biosynthesis activity and protects axon from ...
- Convergence of the Insulin and Serotonin Programs in the Pancreatic beta-Cell
[作者:Ohta, Y; Kosaka, Y; Kishimoto, N; Wang, JH; Smith, SB; Honig, G; Kim, H; Gasa, RM; Neubauer, N; Liou, A; Tecott, LH; Deneris, ES; German, MS,期刊:Diabetes, 页码:3208-3216 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Despite their origins in different germ layers, pancreatic islet cells share many common developmental features with neurons, especially serotonin-producing neurons in the hindbrain. Therefore, we tested whethe...
- IL-21 Is an Antitolerogenic Cytokiine of the Late-Phase Alloimmune Response
[作者:Petrelli, A; Carvello, M; Vergani, A; Lee, KM; Tezza, S; Du, M; Kleffel, S; Liu, CW; Mfarrej, BG; Hwu, P; Secchi, A; Leonard, WJ; Young, D; Sayegh, MH; Markmann, JF; Zajac, AJ; Fiorina, P,期刊:Diabetes, 页码:3223-3234 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Interleukin-21 (IL-21) is a proinflanimatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still u...
- SirT1 Regulates Adipose Tissue Inflammation
[作者:Gillum, MP; Kotas, ME; Erion, DM; Kursawe, R; Chatterjee, P; Nead, KT; Muise, ES; Hsiao, JJ; Frederick, DW; Yonemitsu, S; Banks, AS; Qiang, L; Bhanot, S; Olefsky, JM; Sears, DD; Caprio, S; Shulman, GI,期刊:Diabetes, 页码:3235-3245 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during states of energetic exc...
- Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
[作者:Wang, XJ; Hao, JQ; Metzger, DL; Mui, A; Ao, ZL; Akhoundsadegh, N; Langermann, S; Liu, L; Chen, LP; Ou, DW; Verchere, CB; Warnock, GL,期刊:Diabetes, 页码:3246-3255 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE Autoimmune diabetes is a T cell-mediated disease in which insulin-producing beta-cells are destroyed. Autoreactive T cells play a central role in mediating beta-cell destruction. B7-H4 is a negative cosignaling...
- Single Insulin-Specific CD8(+) T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes
[作者:Luce, S; Lemonnier, F; Briand, JP; Coste, J; Lahlou, N; Muller, S; Larger, E; Rocha, B; Mallone, R; Boitard, C,期刊:Diabetes, 页码:3289-3299 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Both the early steps and the high recurrence of autoinununity once the disease is established are unexplained in human type I. diabetes. Because CD8(+) T cells are central and insulin is a key autoantigen in th...
- Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk
[作者:Bonifacio, E; Warncke, K; Winkler, C; Wallner, M; Ziegler, AG,期刊:Diabetes, 页码:3300-3306 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-The incidence of type 1 diabetes is increasing. Delivery by cesarean section is also more prevalent, and it is suggested that cesarean section is associated with type 1 diabetes risk. We examine associations be...
- Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice (vol 60, pg 2775, 2011)
[作者:Everard, A; Lazarevic, V; Derrien, M; Girard, M; Muccioli, GG; Neyrinck, AM; Possemiers, S; Van Holle, A; Francois, P; de Vos, WM; Delzenne, NM; Schrenzel, J; Cani, PD,期刊:Diabetes, 页码:3307-3307 , 文章类型: Correction,,卷期:2011年60-12]
-
- High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes (vol 60, pg 315, 2011)
[作者:Franc, DT; Kodl, CT; Mueller, BA; Muetzel, RL; Lim, KO; Seaquist, ER,期刊:Diabetes, 页码:3307-3307 , 文章类型: Correction,,卷期:2011年60-12]
-
- beta-Cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion (vol 60, pg 2710, 2011)
[作者:Robson-Doucette, CA; Sultan, S; Allister, EM; Wikstrom, JD; Koshkin, V; Bhattacharjee, A; Prentice, KJ; Sereda, SB; Shirihai, OS; Wheeler, MB,期刊:Diabetes, 页码:3307-3307 , 文章类型: Correction,,卷期:2011年60-12]
-
- Type 1 Diabetes Genetics Consortium. LILA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the Type 1 Diabetes Genetics Consortium families (vol 59, pg 2055, 2010)
[作者:Varney, MD; Valdes, AM; Carlson, JA; Noble, JA; Tait, BD; Bonella, P; Lavant, E; Fear, AL; Louey, A; Moonsamy, P; Mychaleckyj, JC; Erlich, H,期刊:Diabetes, 页码:3308-3310 , 文章类型: Correction,,卷期:2011年60-12]
-
|