- Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse
[作者:Hu, Y; Chopra, V; Chopra, R; Locascio, JJ; Liao, ZX; Ding, HL; Zheng, B; Matson, WR; Ferrante, RJ; Rosas, HD; Hersch, SM; Scherzer, CR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17141-17146 , 文章类型: Article,,卷期:2011年108-41]
- Huntington disease (HD) is a progressive neurodegenerative disease that affects 30,000 individuals in North America. Treatments that slow its relentless course are not yet available, and biomarkers that can reliably meas...
- Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis
[作者:Cheng, B; Anea, CB; Yao, L; Chen, F; Patel, V; Merloiu, A; Pati, P; Caldwell, RW; Fulton, DJ; Rudic, RD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17147-17152 , 文章类型: Article,,卷期:2011年108-41]
- The suprachiasmatic nucleus of the brain is the circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues to control circadian physiology. As such, central clock dysfunction can a...
- Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
[作者:Crawford, MA; Lowe, DE; Fisher, DJ; Stibitz, S; Plaut, RD; Beaber, JW; Zemansky, J; Mehrad, B; Glomski, IJ; Strieter, RM; Hughes, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17159-17164 , 文章类型: Article,,卷期:2011年108-41]
- Chemokines are a family of chemotactic cytokines that function in host defense by orchestrating cellular movement during infection. In addition to this function, many chemokines have also been found to mediate the direct...
- Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei
[作者:Chantratita, N; Rholl, DA; Sim, B; Wuthiekanun, V; Limmathurotsakul, D; Amornchai, P; Thanwisai, A; Chua, HH; Ooi, WF; Holden, MTG; Day, NP; Tan, P; Schweizer, HP; Peacock, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17165-17170 , 文章类型: Article,,卷期:2011年108-41]
- Known mechanisms of resistance to beta-lactam antibiotics include beta-lactamase expression, altered drug target, decreased bacterial permeability, and increased drug efflux. Here, we describe a unique mechanism of beta-...
- A molecular mechanism of direction switching in the flagellar motor of Escherichia coli
[作者:Paul, K; Brunstetter, D; Titen, S; Blair, DF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17171-17176 , 文章类型: Article,,卷期:2011年108-41]
- The direction of flagellar rotation is regulated by a rotor-mounted protein assembly, termed the "switch complex," formed from multiple copies of the proteins FliG, FliM, and FliN. The structures of major parts of these ...
- A small pool of vesicles maintains synaptic activity in vivo
[作者:Denker, A; Bethani, I; Krohnert, K; Korber, C; Horstmann, H; Wilhelm, BG; Barysch, SV; Kuner, T; Neher, E; Rizzoli, SO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17177-17182 , 文章类型: Article,,卷期:2011年108-41]
- Chemical synapses contain substantial numbers of neurotransmitter-filled synaptic vesicles, ranging from approximately 100 to many thousands. The vesicles fuse with the plasma membrane to release neurotransmitter and are...
- Complex genetic architecture of Drosophila aggressive behavior
[作者:Zwarts, L; Magwire, MM; Carbone, MA; Versteven, M; Herteleer, L; Anholt, RRH; Callaerts, P; Mackay, TFC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17070-17075 , 文章类型: Article,,卷期:2011年108-41]
- Epistasis and pleiotropy feature prominently in the genetic architecture of quantitative traits but are difficult to assess in outbred populations. We performed a diallel cross among coisogenic Drosophila P-element mutat...
- Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism
[作者:Horev, G; Ellegood, J; Lerch, JP; Son, YEE; Muthuswamy, L; Vogel, H; Krieger, AM; Buja, A; Henkelman, RM; Wigler, M; Mills, AA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17076-17081 , 文章类型: Article,,卷期:2011年108-41]
- Recurrent copy number variations (CNVs) of human 16p11.2 have been associated with a variety of developmental/neurocognitive syndromes. In particular, deletion of 16p11.2 is found in patients with autism, developmental d...
- Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level
[作者:Di Segni, G; Gastaldi, S; Zamboni, M; Tocchini-Valentini, GP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17082-17086 , 文章类型: Article,,卷期:2011年108-41]
- The orderly expression of specific genes is the basis for cell differentiation. Saccharomyces cerevisiae has two haploid mating types, a and a cells, in which the mating-specific genes are differentially expressed. When ...
- Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
[作者:Kumar, A; White, TA; MacKenzie, AP; Clegg, N; Lee, C; Dumpit, RF; Coleman, I; Ng, SB; Salipante, SJ; Rieder, MJ; Nickerson, DA; Corey, E; Lange, PH; Morrissey, C; Vessella, RL; Nelson, PS; Shendure, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17087-17092 , 文章类型: Article,,卷期:2011年108-41]
- To catalog protein-altering mutations that may drive the development of prostate cancers and their progression to metastatic disease systematically, we performed whole-exome sequencing of 23 prostate cancers derived from...
- Molecular basis for amyloid-beta polymorphism
[作者:Colletier, JP; Laganowsky, A; Landau, M; Zhao, ML; Soriaga, AB; Goldschmidt, L; Flot, D; Cascio, D; Sawaya, MR; Eisenberg, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16938-16943 , 文章类型: Article,,卷期:2011年108-41]
- Amyloid-beta (A beta) aggregates are the main constituent of senile plaques, the histological hallmark of Alzheimer's disease. A beta molecules form beta-sheet containing structures that assemble into a variety of polymo...
- Improving peppermint essential oil yield and composition by metabolic engineering
[作者:Lange, BM; Mahmoud, SS; Wildung, MR; Turner, GW; Davis, EM; Lange, I; Baker, RC; Boydston, RA; Croteau, RB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16944-16949 , 文章类型: Article,,卷期:2011年108-41]
- Peppermint (Mentha x piperita L.) was transformed with various gene constructs to evaluate the utility of metabolic engineering for improving essential oil yield and composition. Oil yield increases were achieved by over...
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