- Comparing machines and humans on a visual categorization test
[作者:Fleuret, F; Li, T; Dubout, C; Wampler, EK; Yantis, S; Geman, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17621-17625 , 文章类型: Article,,卷期:2011年108-43]
- Automated scene interpretation has benefited from advances in machine learning, and restricted tasks, such as face detection, have been solved with sufficient accuracy for restricted settings. However, the performance of...
- Temporal clustering of tropical cyclones and its ecosystem impacts
[作者:Mumby, PJ; Vitolo, R; Stephenson, DB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17626-17630 , 文章类型: Article,,卷期:2011年108-43]
- Tropical cyclones have massive economic, social, and ecological impacts, and models of their occurrence influence many planning activities from setting insurance premiums to conservation planning. Most impact models allo...
- Evidence of magnetic isotope effects during thermochemical sulfate reduction
[作者:Oduro, H; Harms, B; Sintim, HO; Kaufman, AJ; Cody, G; Farquhar, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17635-17638 , 文章类型: Article,,卷期:2011年108-43]
- Thermochemical sulfate reduction experiments with simple amino acid and dilute concentrations of sulfate reveal significant degrees of mass-independent sulfur isotope fractionation. Enrichments of up to 13% for (33)S are...
- Early Archean serpentine mud volcanoes at Isua, Greenland, as a niche for early life
[作者:Pons, ML; Quitte, G; Fujii, T; Rosing, MT; Reynard, B; Moynier, F; Douchet, C; Albarede, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17639-17643 , 文章类型: Article,,卷期:2011年108-43]
- The Isua Supracrustal Belt, Greenland, of Early Archean age (3.81-3.70 Ga) represents the oldest crustal segment on Earth. Its complex lithology comprises an ophiolite-like unit and volcanic rocks reminiscent of boninite...
- Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity
[作者:Chang, A; Singh, S; Helmich, KE; Goff, RD; Bingman, CA; Thorson, JS; Phillips, GN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17649-17654 , 文章类型: Article,,卷期:2011年108-43]
- Glycosyltransferases are useful synthetic catalysts for generating natural products with sugar moieties. Although several natural product glycosyltransferase structures have been reported, design principles of glycosyltr...
- Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
[作者:Drury, LJ; Ziarek, JJ; Gravel, S; Veldkamp, CT; Takekoshi, T; Hwang, ST; Heveker, N; Volkman, BF; Dwinell, MB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17655-17660 , 文章类型: Article,,卷期:2011年108-43]
- Chemokines and chemokine receptors are extensively and broadly involved in cancer metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine CXCL12 sensitizes breast and colon cancer cells to endo...
- Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA
[作者:Tsutakawa, SE; Van Wynsberghe, AW; Freudenthal, BD; Weinacht, CP; Gakhar, L; Washington, MT; Zhuang, ZH; Tainer, JA; Ivanov, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17672-17677 , 文章类型: Article,,卷期:2011年108-43]
- PCNA ubiquitination in response to DNA damage leads to the recruitment of specialized translesion polymerases to the damage locus. This constitutes one of the initial steps in translesion synthesis (TLS)-a critical pathw...
- Extended surfaces modulate hydrophobic interactions of neighboring solutes
[作者:Patel, AJ; Varilly, P; Jamadagni, SN; Acharya, H; Garde, S; Chandler, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17678-17683 , 文章类型: Article,,卷期:2011年108-43]
- Interfaces are a most common motif in complex systems. To understand how the presence of interfaces affects hydrophobic phenomena, we use molecular simulations and theory to study hydration of solutes at interfaces. The ...
- Structure and function of multiple Ca(2+)-binding sites in a K(+) channel regulator of K(+) conductance (RCK) domain
[作者:Pau, VPT; Smith, FJ; Taylor, AB; Parfenova, LV; Samakai, E; Callaghan, MM; Abarca-Heidemann, K; Hart, PJ; Rothberg, BS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17684-17689 , 文章类型: Article,,卷期:2011年108-43]
- Regulator of K(+) conductance (RCK) domains control the activity of a variety of K(+) transporters and channels, including the human large conductance Ca(2+)-activated K(+) channel that is important for blood pressure re...
- Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process
[作者:Freire-De-Lima, L; Gelfenbeyn, K; Ding, Y; Mandel, U; Clausen, H; Handa, K; Hakomori, SI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17690-17695 , 文章类型: Article,,卷期:2011年108-43]
- The process termed "epithelial-mesenchymal transition" (EMT) was originally discovered in ontogenic development, and has been shown to be one of the key steps in tumor cell progression and metastasis. Recently, we showed...
- Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression
[作者:Hartford, SA; Luo, YH; Southard, TL; Min, IM; Lis, JT; Schimenti, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17702-17707 , 文章类型: Article,,卷期:2011年108-43]
- Effective DNA replication is critical to the health and reproductive success of organisms. The six MCM2-7 proteins, which form the replicative helicase, are essential for high-fidelity replication of the genome. Many euk...
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