个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共25条记录   SnapShot: Human Biomedical Genomics [作者：Kenny, EE; Bustamante, CD,期刊：Cell, 页码：248-NIL_262 , 文章类型： Editorial Material，,卷期：2011年147-1] A Blueprint for Advancing Genetics-Based Cancer Therapy [作者：Sellers, WR,期刊：Cell, 页码：26-31 , 文章类型： Article，,卷期：2011年147-1] In the era of next-generation sequencing, there are significant challenges to harnessing cancer genome information to develop novel therapies. Key research thrusts in both academia and industry will speed this transition... Clan Genomics and the Complex Architecture of Human Disease [作者：Lupski, JR; Belmont, JW; Boerwinkle, E; Gibbs, RA,期刊：Cell, 页码：32-43 , 文章类型： Article，,卷期：2011年147-1] Human diseases are caused by alleles that encompass the full range of variant types, from single-nucleotide changes to copy-number variants, and these variations span a broad frequency spectrum, from the very rare to the... Metagenomics and Personalized Medicine [作者：Virgin, HW; Todd, JA,期刊：Cell, 页码：44-56 , 文章类型： Article，,卷期：2011年147-1] The microbiome is a complex community of Bacteria, Archaea, Eukarya, and viruses that infect humans and live in our tissues. It contributes the majority of genetic information to our metagenome and, consequently, influen... Mapping Rare and Common Causal Alleles for Complex Human Diseases [作者：Raychaudhuri, S,期刊：Cell, 页码：57-69 , 文章类型： Article，,卷期：2011年147-1] Advances in genotyping and sequencing technologies have revolutionized the genetics of complex disease by locating rare and common variants that influence an individual's risk for diseases, such as diabetes, cancers, and... Modeling Human Disease in Humans: The Ciliopathies [作者：Novarino, G; Akizu, N; Gleeson, JG,期刊：Cell, 页码：70-79 , 文章类型： Review，,卷期：2011年147-1] Soon, the genetic basis of most human Mendelian diseases will be solved. The next challenge will be to leverage this information to uncover basic mechanisms of disease and develop new therapies. To understand how this tr... The Lin28/let-7 Axis Regulates Glucose Metabolism [作者：Zhu, H; Shyh-Chang, N; Segre, AV; Shinoda, G; Shah, SP; Einhorn, WS; Takeuchi, A; Engreitz, JM; Hagan, JP; Kharas, MG; Urbach, A; Thornton, JE; Triboulet, R; Gregory, RI; Altshuler, D; Daley, GQ,期刊：Cell, 页码：81-94 , 文章类型： Article，,卷期：2011年147-1] The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin2... Human Genome: What's Been Most Surprising? [作者：Page, D; Cheung, V; Haussler, D; Gibbs, R,期刊：Cell, 页码：9-10 , 文章类型： News Item，,卷期：2011年147-1] Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes [作者：Klein, IA; Resch, W; Jankovic, M; Oliveira, T; Yamane, A; Nakahashi, H; Di Virgilio, M; Bothmer, A; Nussenzweig, A; Robbiani, DF; Casellas, R; Nussenzweig, MC,期刊：Cell, 页码：95-106 , 文章类型： Article，,卷期：2011年147-1] Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias,...