- Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901
[作者：Sheth, PR; Liu, YQ; Hesson, T; Zhao, J; Vilenchik, L; Liu, YH; Mayhood, TW; Le, HV,期刊：Biochemistry, 页码：7964-7976 , 文章类型： Article，,卷期：2011年50-37]
- Kinases catalyze the transfer of gamma-phosphate from ATP to substrate protein residues triggering signaling pathways responsible for a plethora of cellular events. Isolation and production of homogeneous preparations of...
- The Cation-pi Interaction between Lys53 and the Flavin of Fructosamine Oxidase (FAOX-II) Is Critical for Activity
[作者：Collard, F; Fagan, RL; Zhang, JY; Nemet, I; Palfey, BA; Monnier, VM,期刊：Biochemistry, 页码：7977-7986 , 文章类型： Article，,卷期：2011年50-37]
- Fructosamine oxidases (FAOXs) are flavin-containing enzymes that catalyze the oxidative deglycation of low molecular weight fructosamines or Amadori products. The fructosamine substrate is oxidized by the flavin in the r...
- Influence of the Covalent Heme-Protein Bonds on the Redox Thermodynamics of Human Myeloperoxidase
[作者：Battistuzzi, G; Stampler, J; Bellei, M; Vlasits, J; Soudi, M; Furtmuller, PG; Obinger, C,期刊：Biochemistry, 页码：7987-7994 , 文章类型： Article，,卷期：2011年50-37]
- Myeloperoxidase (MPO) is the most abundant neutrophil enzyme and catalyzes predominantly the two-electron oxidation of ubiquitous chloride to generate the potent bleaching hypochlorous acid, thus contributing to pathogen...
- Human Defensin 5 Disulfide Array Mutants: Disulfide Bond Deletion Attenuates Antibacterial Activity against Staphylococcus aureus
[作者：Wanniarachchi, YA; Kaczmarek, P; Wan, A; Nolan, EM,期刊：Biochemistry, 页码：8005-8017 , 文章类型： Article，,卷期：2011年50-37]
- Human alpha-defensin 5 (HD5, HD5(ox) to specify the oxidized and disulfide linked form) is a 32-residue cysteine-rich host-defense peptide, expressed and released by small intestinal Paneth cells, that exhibits antibacte...
- Structure, Stability, and Interaction of Fibrin alpha C-Domain Polymers
[作者：Tsurupa, G; Mahid, A; Veklich, Y; Weisel, JW; Medved, L,期刊：Biochemistry, 页码：8028-8037 , 文章类型： Article，,卷期：2011年50-37]
- Our previous studies revealed that in fibrinogen the alpha C-domains are not reactive with their ligands, suggesting that their binding sites are cryptic and become exposed upon its conversion to fibrin, in which these d...
- Importance of Domain Closure for the Autoactivation of ERK2
[作者：Barr, D; Oashi, T; Burkhard, K; Lucius, S; Samadani, R; Zhang, J; Shapiro, P; MacKerell, AD; van der Vaart, A,期刊：Biochemistry, 页码：8038-8048 , 文章类型： Article，,卷期：2011年50-37]
- Extracellular signal-regulated Kinases 1 and 2 (ERK1 and -2, respectively) play a critical role in regulating cell division and have been implicated in cancer. In addition to activation by MAPK/ERK kinases 1 and 2 (MEK1 ...
- Understanding the Errors of SHAPE-Directed RNA Structure Modeling
[作者：Kladwang, W; VanLang, CC; Cordero, P; Das, R,期刊：Biochemistry, 页码：8049-8056 , 文章类型： Article，,卷期：2011年50-37]
- Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2'-hydroxyl...
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