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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   An Extended beta 7 alpha 7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase [作者：Allison, TM; Hutton, RD; Jiao, WT; Gloyne, BJ; Nimmo, EB; Jameson, GB; Parker, EJ,期刊：Biochemistry, 页码：9318-9327 , 文章类型： Article，,卷期：2011年50-43] The enzyme 3-deoxy-D-manno-octulosonate 8-phosphate (KDO8P) synthase catalyzes the reaction between phosphoenolpyruvate and arabinose 5-phosphate (ASP) in the first committed step in the biosynthetic pathway for the form... Dynamics in the Active Site of beta-Secretase: A Network Analysis of Atomistic Simulations [作者：Mishra, S; Caflisch, A,期刊：Biochemistry, 页码：9328-9339 , 文章类型： Article，,卷期：2011年50-43] The aspartic protease beta-secretase (BACE) catalyzes the hydrolysis of the amyloid precursor protein (APP) which leads to amyloid-beta aggregation and, ultimately, the perilous Alzheimer's disease. The conformational dy... p-Thiophenylalanine-Induced DNA Cleavage and Religation Activity of a Modified Vaccinia Topoisomerase IB [作者：Chen, SX; Zhang, Y; Hecht, SM,期刊：Biochemistry, 页码：9340-9351 , 文章类型： Article，,卷期：2011年50-43] Vaccinia DNA topoisomerase IB is the smallest of the type IB topoisomerases. Because of its small size (314 amino acids) and target site specificity (5'(C/T)CCTTp(down arrow) sites), it constitutes an excellent model for... Stability and Mismatch Discrimination of Locked Nucleic Acid-DNA Duplexes [作者：Owczarzy, R; You, Y; Groth, CL; Tataurov, AV,期刊：Biochemistry, 页码：9352-9367 , 文章类型： Article，,卷期：2011年50-43] Locked nucleic acids (LNA; symbols of bases, +A, +C, +G, and +T) are introduced into chemically synthesized oligonucleotides to increase duplex stability and specificity. To understand these effects, we have determined t... Engineering a Structure Switching Mechanism into a Steroid-Binding Aptamer and Hydrodynamic Analysis of the Ligand Binding Mechanism [作者：Reinstein, O; Neves, MAD; Saad, M; Boodram, SN; Lombardo, S; Beckham, SA; Brouwer, J; Audette, GF; Groves, P; Wilce, MCJ; Johnson, PE,期刊：Biochemistry, 页码：9368-9376 , 文章类型： Article，,卷期：2011年50-43] The steroid binding mechanism of a DNA aptamer was studied using isothermal titration calorimetry (ITC), NMR spectroscopy, quasi-elastic light scattering (QELS), and small-angle X-ray spectroscopy (SAXS). Binding affinit... The Structural Role of N-Linked Glycans on Human Glypican-1 [作者：Svensson, G; Wittsten, AH; Linse, S; Mani, K,期刊：Biochemistry, 页码：9377-9387 , 文章类型： Article，,卷期：2011年50-43] Glypicans are cell-surface heparan sulfate proteoglycans that regulate developmental signaling pathways by binding growth factors to their heparan sulfate chains. The primary structures of glypican core proteins contain ... The Enzymatic Activities of the Escherichia coli Basic Aliphatic Amino Acid Decarboxylases Exhibit a pH Zone of Inhibition [作者：Kanjee, U; Gutsche, I; Ramachandran, S; Houry, WA,期刊：Biochemistry, 页码：9388-9398 , 文章类型： Article，,卷期：2011年50-43] The stringent response regulator ppGpp has recently been shown by our group to inhibit the Escherichia coil inducible lysine decarboxylase, LdcI. As a follow-up to this observation, we examined the mechanisms that regula...