- Manipulating Cofactor Binding Thermodynamics in an Artificial Oxygen Transport Protein
[作者:Zhang, L; Anderson, JLR; Ahmed, I; Norman, JA; Negron, C; Mutter, AC; Dutton, PL; Koder, RL,期刊:Biochemistry, 页码:10254-10261 , 文章类型: Article,,卷期:2011年50-47]
- We report the mutational analysis of an artificial oxygen transport protein, HP7, which operates via a mechanism akin to that of human neuroglobin and cytoglobin. This protein destabilizes one of two heme-ligating histid...
- Oxy Intermediates of Homoprotocatechuate 2,3-Dioxygenase: Facile Electron Transfer between Substrates
[作者:Mbughuni, MM; Chakrabarti, M; Hayden, JA; Meier, KK; Dalluge, JJ; Hendrich, MP; Munck, E; Lipscomb, JD,期刊:Biochemistry, 页码:10262-10274 , 文章类型: Article,,卷期:2011年50-47]
- Substrates homoprotocatechuate (HPCA) and O(2) bind to the Fe(II) of homoprotocatechuate 2,3-dioxygenase (FeHPCD) in adjacent coordination sites. Transfer of an electron(s) from HPCA to O(2) via the iron is proposed to a...
- Mossbauer and EPR Study of Iron in Vacuoles from Fermenting Saccharomyces cerevisiae
[作者:Cockrell, AL; Holmes-Hampton, GP; McCormick, SP; Chakrabarti, M; Lindahl, PA,期刊:Biochemistry, 页码:10275-10283 , 文章类型: Article,,卷期:2011年50-47]
- Vacuoles were isolated from fermenting yeast cells grown on minimal medium supplemented with 40 mu M (57)Fe. Absolute concentrations of Fe, Cu, Zn, Mn, Ca, and P in isolated vacuoles were determined by ICP-MS. Mossbauer ...
- 1 alpha,25-Dihydroxyvitamin D(3) Signaling Pathways on Calcium Uptake in 30-Day-Old Rat Sertoli Cells
[作者:Zanatta, L; Zamoner, A; Goncalves, R; Zanatta, AP; Bouraima-Lelong, H; Carreau, S; Silva, FRMB,期刊:Biochemistry, 页码:10284-10292 , 文章类型: Article,,卷期:2011年50-47]
- 1 alpha,25-Dihydroxyvitamin D(3) (1,25D(3)) is the active metabolite of vitamin D(3) and the major calcium regulatory hormone in tissues. The aim of this work was to investigate the mechanism of action of 1,25D(3) on (45...
- Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport
[作者:Patterson, KR; Ward, SM; Combs, B; Voss, K; Kanaan, NM; Morfini, G; Brady, ST; Gamblin, TC; Binder, LI,期刊:Biochemistry, 页码:10300-10310 , 文章类型: Article,,卷期:2011年50-47]
- Aggregation and accumulation of the microtubule-associated protein tau are associated with cognitive decline and neuronal degeneration in Alzheimer's disease and other tauopathies. Thus, preventing the transition of tau ...
- Structural and Functional Impact of Site-Directed Methionine Oxidation in Myosin
[作者:Klein, JC; Moen, RJ; Smith, EA; Titus, MA; Thomas, DD,期刊:Biochemistry, 页码:10318-10327 , 文章类型: Article,,卷期:2011年50-47]
- We have examined the structural and functional effects of site-directed methionine oxidation in Dictyostelium (Dicty) myosin II using mutagenesis, in vitro oxidation, and site-directed spin-labeling for electron paramagn...
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