- Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide
[作者:Taghibiglou, C; Lu, J; Mackenzie, IR; Wang, YT; Cashman, NR,期刊:Biochemical and Biophysical Research Communications, 页码:159-163 , 文章类型: Article,,卷期:2011年413-2]
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons in which glutamatergic excitotoxicity may participate. A recently characterized downstream effector of glutamatergic excitotoxicit...
- A unique EF-hand motif in mnemiopsin photoprotein from Mnemiopsis leidyi: Implication for its low calcium sensitivity
[作者:Jafarian, V; Sariri, R; Hosseinkhani, S; Aghamaali, MR; Sajedi, RH; Taghdir, M; Hassannia, S,期刊:Biochemical and Biophysical Research Communications, 页码:164-170 , 文章类型: Article,,卷期:2011年413-2]
- Up to now, all reported Ca(2+)-regulated photoproteins, except for mnemiopsin, have been cloned and expressed in Escherichia coli. In this study, the cDNA for an isotype of mnemiopsin, from the ctenophore Mnemiopsis leid...
- Conserved GC-boxes, E-box and GATA motif are essential for GATA-4 gene expression in P19CL6 cells
[作者:Ishibashi, T; Yokura, Y; Ohashi, K; Yamamoto, H; Maeda, M,期刊:Biochemical and Biophysical Research Communications, 页码:171-175 , 文章类型: Article,,卷期:2011年413-2]
- The promoter of the GATA-4 gene was analyzed in P19CL6 cells. A 124 bp segment containing conserved two GC-boxes and E-box was essential for the basal promoter activity, as determined with a transient luciferase reporter...
- The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo
[作者:Kim, BS; Park, H; Ko, SH; Lee, WK; Kwon, HJ,期刊:Biochemical and Biophysical Research Communications, 页码:189-193 , 文章类型: Article,,卷期:2011年413-2]
- Sphingosine-1-phosphate (S1P) plays an important role in angiogenesis by stimulating DNA synthesis, chemotactic motility, and early blood vessel formation. Accordingly, the S1P signaling pathway is an attractive target f...
- Effect of heparin and alendronate coating on titanium surfaces on inhibition of osteoclast and enhancement of osteoblast function
[作者:Moon, HJ; Yun, YP; Han, CW; Kim, MS; Kim, SE; Bae, MS; Kim, GT; Choi, YS; Hwang, EH; Lee, JW; Lee, JM; Lee, CH; Kim, DS; Kwon, IK,期刊:Biochemical and Biophysical Research Communications, 页码:194-200 , 文章类型: Article,,卷期:2011年413-2]
- The failure of orthopedic and dental implants has been attributed mainly to loosening of the implant from host bone, which may be due to weak bonding of the implant material to bone tissue. Titanium (Ti) is used in the f...
- Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2 alpha through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms
[作者:Higashimura, Y; Terai, T; Yamaji, R; Mitani, T; Ogawa, M; Harada, N; Inui, H; Nakano, Y,期刊:Biochemical and Biophysical Research Communications, 页码:201-205 , 文章类型: Article,,卷期:2011年413-2]
- Despite their structural similarity, hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha have distinct functional properties and exhibit distinct spatiotemporal expression patterns, suggesting that the expressions of ...
- Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia
[作者:Pfeilschifter, W; Czech-Zechmeister, B; Sujak, M; Mirceska, A; Koch, A; Rami, A; Steinmetz, H; Foerch, C; Huwiler, A; Pfeilschifter, J,期刊:Biochemical and Biophysical Research Communications, 页码:212-217 , 文章类型: Article,,卷期:2011年413-2]
- The two ubiquitously expressed sphingosine kinases (SphK) 1 and 2 are key regulators of the sphingolipid signaling pathway. Despite the formation of an identical messenger. i.e. sphingosine 1-phosphate (S1P), they exert ...
- Optical observation of cell sonoporation with low intensity ultrasound
[作者:Nejad, SM; Hosseini, SHR; Akiyama, H; Tachibana, K,期刊:Biochemical and Biophysical Research Communications, 页码:218-223 , 文章类型: Article,,卷期:2011年413-2]
- Sonoporation is a promising drug delivery technique with great potential in medicine. However, its applications have been limited mostly by the lack of understanding its underlying biophysical mechanism, partly due to th...
- A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions
[作者:Akashi, M; Higashi, T; Masuda, S; Komori, T; Furuse, M,期刊:Biochemical and Biophysical Research Communications, 页码:224-229 , 文章类型: Article,,卷期:2011年413-2]
- Cell-cell junctioris play crucial roles in the organization and function of epithelial and endothelial cellular sheets. Here, we have identified the protein product for KIAA1462 gene, whose single nucleotide polymorphism...
|