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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共54条记录   Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma [作者：Praveen, C; Ayyanar, A; Perumal, PT,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4170-4173 , 文章类型： Article，,卷期：2011年21-14] A highly regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones via gold(III) chloride catalyzed cyclo-isomerization of 3-ethynyl-indole-2-carboxylic acid was achieved in good to excellent yields. These compounds were... Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines [作者：Bruyere, C; Genovese, S; Lallemand, B; Ionescu-Motatu, A; Curini, M; Kiss, R; Epifano, F,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4174-4179 , 文章类型： Article，,卷期：2011年21-14] A series of 25 selected oxyprenylated natural phenylpropanoids were synthesized, and their growth inhibitory activities were evaluated in vitro together with 14 other commercially available non-alkylated compounds belong... Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin [作者：Tanaka, R; Kato, M; Suzuki, T; Nakazaki, A; Nozaki, E; Gotoh, M; Murakami-Murofushi, K; Kobayashi, S,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4180-4182 , 文章类型： Article，,卷期：2011年21-14] The efficient synthesis of 3-O-thia-cPAs (4a-d), sulfur analogues of cyclic phosphatidic acid (cPA), has been achieved. The key step of the synthesis is an intramolecular Arbuzov reaction to construct the cyclic thiophos... Discovery of novel SecA inhibitors of Candidatus Liberibacter asiaticus by structure based design [作者：Akula, N; Zheng, H; Han, FQ; Wang, N,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4183-4188 , 文章类型： Article，,卷期：2011年21-14] Candidatus Liberibacter asiaticus is the causal agent of Huanglongbing (HLB) disease of citrus. Current management practices have not been able to control HLB and stop the spread of HLB. The current study is focused on s... A reverse method for diversity introduction of benzimidazole to synthesize H(+)/K(+)-ATP enzyme inhibitors [作者：Yan, Y; Liu, ZJ; Zhang, JJ; Xu, RM; Hu, X; Liu, G,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4189-4192 , 文章类型： Article，,卷期：2011年21-14] A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two k... Novel quinoxaline derivatives for in vivo imaging of beta-amyloid plaques in the brain [作者：Cui, MC; Ono, M; Kimura, H; Liu, BL; Saji, H,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4193-4196 , 文章类型： Article，,卷期：2011年21-14] In a search for new probes to detect beta-amyloid plaques in the brain of patients with Alzheimer's disease (AD), we have synthesized and evaluated a series of quinoxaline derivatives containing a '6+6-6' ring system. Th... 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity [作者：Xu, WC; Wright, GE; Brown, NC; Long, ZY; Zhi, CX; Dvoskin, S; Gambino, JJ; Barnes, MH; Butler, MM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4197-4202 , 文章类型： Article，,卷期：2011年21-14] Several 2-anilino- and 2-benzylamino-3-deaza-6-oxopurines [3-deazaguanines] and selected 8-methyl and 8-aza analogs have been synthesized. 7-Substituted N(2)-(3-ethyl-4-methylphenyl)-3-deazaguanines were potent and selec... Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors [作者：Lee, J; Kim, KH; Jeong, S,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4203-4205 , 文章类型： Article，,卷期：2011年21-14] A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity agains... BODIPY-modified 2 '-deoxyguanosine as a novel tool to detect DNA damages [作者：Takamura-Enya, T; Ishii, R,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4206-4209 , 文章类型： Article，,卷期：2011年21-14] BODIPY-modified 2'-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by ... Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents [作者：Li, Y; Wang, XL; Fu, R; Yu, WY; Wang, XL; Lai, YS; Peng, SX; Zhang, YH,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4210-4214 , 文章类型： Article，,卷期：2011年21-14] Most ischemic stroke results from brain blood vessel blockage by platelet-mediated thrombus, and antiplatelet therapy has been demonstrated clinical benefits in the treatment of this disease. In the present work, novel n... Selective non zinc binding inhibitors of MMP13 [作者：De Savi, C; Morley, AD; Ting, A; Nash, I; Karabelas, K; Wood, CM; James, M; Norris, SJ; Karoutchi, G; Rankine, N; Hamlin, G; MacFaul, PA; Ryan, D; Baker, SV; Hargreaves, D; Gerhardt, S,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4215-4219 , 文章类型： Article，,卷期：2011年21-14] Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-cr... Eudistomidins H-K, new beta-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus [作者：Suzuki, T; Kubota, T; Kobayashi, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4220-4223 , 文章类型： Article，,卷期：2011年21-14] Four new beta-carboline alkaloids, eudistomidins H-K (1-4), were isolated from an Okinawan marine tunicate Eudistoma glaucus and the structures of 1-4 were elucidated on the basis of spectroscopic data. Eudistomidins H (... MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins [作者：Matos, MJ; Vazquez-Rodriguez, S; Uriarte, E; Santana, L; Vina, D,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4224-4227 , 文章类型： Article，,卷期：2011年21-14] With the aim of finding the structural features for the human MAO inhibitory activity and selectivity, in the present communication we report the synthesis, pharmacological evaluation and a comparative study of a new ser... Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights [作者：Gradler, U; Fuchss, T; Ulrich, WR; Boer, R; Strub, A; Hesslinger, C; Anezo, C; Diederichs, K; Zaliani, A,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4228-4232 , 文章类型： Article，,卷期：2011年21-14] Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause s... Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines [作者：Jorda, R; Sacerdoti-Sierra, N; Voller, J; Havlicek, L; Kracalikova, K; Nowicki, MW; Nasereddin, A; Krystof, V; Strnad, M; Walkinshaw, MD; Jaffe, CL,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4233-4237 , 文章类型： Article，,卷期：2011年21-14] We report here results of screening directed to finding new anti-leishmanial drugs among 2,6-disubstituted purines and corresponding 3,7-disubstituted pyrazolo[4,3-d]pyrimidines. These compounds have previously been show... Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening [作者：Yu, ZH; Chen, L; Wu, L; Liu, SJ; Wang, L; Zhang, ZY,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4238-4242 , 文章类型： Article，,卷期：2011年21-14] SHP2, encoded by PTPN11, is a non-receptor protein tyrosine phosphatase (PTP) containing two tandem Src homology-2 (SH2) domains. It is expressed ubiquitously and plays critical roles in growth factor mediated processes,...